6210a lc tof

Unless otherwise noted, all materials for the synthetic chemistry portion were obtained from commercial suppliers (Combi-Blocks, CombiPhos, Fisher Scientific, Sigma-Aldrich, or VWR) and used without further purification. The ¹H-and ¹³C-NMR spectra were recorded on a Bruker AVANCE 500 MHz spectrometer using CDCl₃ or CD₃OD as the solvent. Chemical shifts are expressed in ppm (δ scale) and referenced to residual protonated solvent. When peak multiplicities are reported, the following abbreviations are used: s (singlet), d (doublet), t (triplet), q (quartet), m (multiplet), or br s (broad singlet). Thin layer chromatography (TLC) was performed on glass backed Merck silica gel 60 F₂₅₄ plates, column chromatography was performed using KP-SIL silica gel (Biotage, USA), and flash column chromatography was performed on Biotage prepacked columns using the automated flash chromatography system Biotage Isolera One. The purities of all the final compounds were of > 95% as determined by UPLC analysis unless otherwise indicated. High Resolution Mass analysis was performed on an Agilent 6210A LC-TOF.

Unless otherwise noted, all materials for the synthetic chemistry portion were obtained from commercial suppliers (e.g. Combi-Blocks, CombiPhos, Fisher Scientific, Sigma-Aldrich, VWR) and used without further purification. The ¹H-and ¹³C-NMR spectra were recorded on a Bruker AVANCE 500 MHz spectrometer using CDCl₃ or CD₃OD as the solvent. Chemical shifts are expressed in ppm (δ scale) and referenced to residual protonated solvent. When peak multiplicities are reported, the following abbreviations are used: s (singlet), d (doublet), t (triplet), q (quartet), m (multiplet), or br s (broad singlet). Thin layer chromatography (TLC) was performed on glass backed Merck silica gel 60 F₂₅₄ plates, column chromatography was performed using KP-SIL silica gel (Biotage, USA), and flash column chromatography was performed on Biotage prepacked columns using the automated flash chromatography system Biotage Isolera One. The purities of all final compounds were > 95% as determined by UPLC analysis unless otherwise indicated. High Resolution Mass analysis was performed on an Agilent 6210A LC-TOF.