Integrated research workflow 4

Manufactured by Siemens

Integrated Research Workflow 4.0 is a comprehensive lab equipment solution from Siemens. It streamlines and integrates various processes involved in research and development. The product offers features for data management, analysis, and collaboration to enhance efficiency and productivity in the laboratory setting.

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Lab products found in correlation

Biograph 40, by Siemens (1 mentions)

2 protocols using integrated research workflow 4

Dynamic PET Imaging and Kinetic Analysis

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Sixty minutes of dynamic PET images were obtained on a Siemens Biograph 40 PET/CT scanner after intravenously injecting 370 ± 18 MBq (10.0 ± 0.5 mCi) of ¹⁸F-FDG. Venous blood samples were obtained throughout the scan as previously described [25 (link), 26 (link)]. A low-dose computed tomography (CT) scan was obtained for attenuation correction of the PET images. All scans were analyzed using Integrated Research Workflow 4.0 (Siemens) as previously described [25 (link), 26 (link), 37 (link)]. Briefly, the baseline and post-endotoxin PET and CT scans were coregistered. Volumes of interest (VOIs) were then placed on the CT images in areas of post-procedure airspace inflammation and transferred to the PET images to extract the time-activity curves. The Patlak graphical analysis was used to calculate the influx constant K_i [38 (link), 39 (link)]. The SUV_mean at 60 min after tracer injection was quantified for ¹⁸F-FDG uptake from the same VOIs used for the Patlak analysis.

Chen D.L., Huang H.J., Byers D.E., Shifren A., Belikoff B., Engle J.T., Arentson E., Kemp D., Phillips S., Scherrer D.E., Fujiwara H., Spayd K.J., Brooks F.J., Pierce R.A., Castro M, & Isakow W. (2018). The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study. PLoS ONE, 13(2), e0191783.

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Quantifying Lung Inflammation with 18F-NOS PET

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The DICOM PET and CT image files were imported into Integrated Research Workflow 4.0 (Siemens) for analysis. The preendotoxin PET and CT images were aligned to the coregistered postendotoxin PET and CT images. Volumes of interest (VOIs) were placed on the areas of infiltrate in the right middle lobe and in an equivalent region of lung on the left using standard lung windows (center, −500 Hounsfield units [HUs]; width, 1,500 HU). The time–activity curves were then extracted from these VOIs on both the baseline and the postendotoxin ¹⁸F-NOS PET scans. A VOI over the main pulmonary artery served as the reference region for the Logan plot analysis (28 (link)), which determined the distribution volume ratio (DVR) for ¹⁸F-NOS. The supplemental materials provide details.

Huang H.J., Isakow W., Byers D.E., Engle J.T., Griffin E.A., Kemp D., Brody S.L., Gropler R.J., Miller J.P., Chu W., Zhou D., Pierce R.A., Castro M., Mach R.H, & Chen D.L. (2014). Imaging Pulmonary Inducible Nitric Oxide Synthase Expression with PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 76-81.

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