Dba 1j

A list of mouse strains used in the study is presented in table S1. Mice were maintained in a pathogen-free, temperature-controlled (23°C), and humidity-controlled (55%) facility with a 12-hour (6:00 a.m. to 6:00 p.m.) light-dark cycle. Mice had free access to food and water. WT male mice (DBA/1J) were obtained from Japan SLC (Shizuoka, Japan). KO (DBA/1J background) and Glia-KO (ABCA1^flox/flox::GFAP-Cre, C57BL/6J background) mice were provided by F. Okajima (Gunma University, Japan) and M. Hayden (British Columbia, Canada), respectively. As a control (Ctr) for Glia-KO mice, we used littermate ABCA1^flox/flox mice. All animal experiments were replicated at least three times.

Dcir^−/− mice were generated as described (Fujikado et al., 2008 (link)), and these mice were backcrossed to C57BL/6J for 12 generations. 2D2 TCR transgenic (2D2 Tg) mice were purchased from The Jackson Laboratory. All the mice used in these experiments were 8–12 wk old, and these age- and sex-matched control C57BL/6J and DBA/1J mice were purchased from Japan SLC, Inc. All the mice were housed in specific pathogen–free animal rooms of the Research Institute for Biomedical Sciences, Tokyo University of Science, and the Tohoku Medical and Pharmaceutical University. Animal experiments were performed following the guidelines of each university and were approved by the Animal Experimental Committee of the Tokyo University of Science and the Animal Experiments Committee of Tohoku Medical and Pharmaceutical University.