Three-component coupling of aldehydes, alkynes, and amines (including the A3 coupling reaction and the redox-A3 reaction) via C‒H activation was carried out under the atmosphere of dried and purified N2 using standard Schlenk. Toluene and THF were dried over sodium/benzophenone and distilled under nitrogen prior to use. DCM was dried over calcium hydride and distilled under nitrogen prior to use. Ethanol and methanol were dried over Iodine/magnesium strips and distilled under nitrogen prior to use. The other dry solvent including 1,4-dioxane, acetonitrile and DCE were directly purchased from Energy Chemical. BINAP, 3,5-diphenyl-pyrazole, aldehydes, alkynes and amines were purchased from Bidepharm, Energy Chemical and Heowns without further purification. The Vulcan XC-72 carbon black was purchased from Macklin.
Binap
Manufactured by Bide Pharmatech
Sourced in China
BINAP is a chiral ligand widely used in asymmetric catalysis. It consists of two naphthalene rings connected by a biaryl phosphine backbone. BINAP provides a chiral environment that enables the selective formation of one enantiomer of the desired product.
Automatically generated - may contain errors
2 protocols using binap
1
Three-Component Coupling via C-H Activation
2
Synthesis of Substituted Anilines
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Reagents for the synthesis of compounds 1–8 and solvents for crystallization were purchased from commercial sources: 4-chlorobenzoic acid, Cs2CO3, BINAP, and 2,4,6-trimethylaniline were from Bidepharm (Shanghai, China); aniline, 2-methylaniline, 3-methylaniline, 4-methylaniline, and 2,6-dimethylaniline were from Energy Chemical (Shanghai, China); 2,3-dimethylaniline and 3,4-dimethylaniline were from Meryer Chemical (Shanghai, China); Pd(OAc)2 was from Rock New Materials (Shaanxi, China); the solvents used for crystallization were from Sinopharm Chemical Reagent Co., Ltd (Shanghai, China).
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!