Precision xtra

Manufactured by Abbott

Sourced in United States, United Kingdom

The Precision Xtra is a compact and portable blood glucose monitoring system designed for professional use. It provides precise and reliable blood glucose measurements to support healthcare providers in their clinical decision-making.

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Lab products found in correlation

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70 protocols using precision xtra

Measurement of Blood Lactate, Ketones, and Gases

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Finger capillary blood lactate (Lactate Plus, Nova Biomedical), ketones (β-hydroxybutyrate; Precision Xtra, Abbott Diabetes Care Inc., Almeda, CA, United States) and glucose (Precision Xtra, Abbott Diabetes Care Inc., Almeda, CA, United States) concentrations were measured. Additional fingertip capillary whole blood droplets were collected within 100 μl capillary tubes and then transferred to a disposable CG4 + cartridge (Abbott Point of Care Inc., Princeton, NJ, United States) and then analyzed for blood pH, HCO₃^–, PO₂, PCO₂, SaO₂, and TCO₂ with the i-STAT analyzer (Abbott Point of Care Inc., Princeton, NJ, United States), which was calibrated prior to each session in accordance with manufacturer’s guidelines (Sediame et al., 1999 (link)). Fingertip blood samples were collected using a lancet following alcohol cleaning. The first droplet was wiped away with a cotton swab and the subsequent droplets were used for analysis. Blood samples were measured before supplementation (baseline; PRE), 30 min after supplementation (30 min), at the end of each set of the VH (VH Set 1–4; blood gases only at end of VH Set 2), immediately post-exercise (IPE), and 15 min after exercise (+ 15 min; recovery).

Prins P.J., Buxton J.D., McClure T.S., D’Agostino D.P., Ault D.L., Welton G.L., Jones D.W., Atwell A.D., Slack M.A., Slack M.L., Williams C.E., Blanchflower M.E., Kannel K.K., Faulkner M.N., Szmaciasz H.L., Croll S.M., Stanforth L.M., Harris T.D., Gwaltney H.C, & Koutnik A.P. (2021). Ketone Bodies Impact on Hypoxic CO2 Retention Protocol During Exercise. Frontiers in Physiology, 12, 780755.

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Fingertip Blood Sampling and Analysis

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Blood samples were measured via fingertip blood samples collected using a lancet following cleaning of the fingertip with an alcohol swab and then dried. The first droplet was wiped away with a cotton swab to remove any alcohol and the subsequent droplets were used for analysis. Samples were immediately processed for measurement of blood lactate (Lactate Plus, Nova Biomedical), ketones (R-β-hydroxybutyrate; Precision Xtra, Abbott Diabetes Care Inc., Almeda, CA) and glucose (Precision Xtra, Abbott Diabetes Care Inc., Almeda, CA) concentrations.

Prins P.J., Noakes T.D., Buga A., D’Agostino D.P., Volek J.S., Buxton J.D., Heckman K., Jones D.W., Tobias N.E., Grose H.M., Jenkins A.K., Jancay K.T, & Koutnik A.P. (2023). Low and high carbohydrate isocaloric diets on performance, fat oxidation, glucose and cardiometabolic health in middle age males. Frontiers in Nutrition, 10, 1084021.

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Capillary Blood Sampling for Metabolite Analysis

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Fingertip (capillary) blood samples for blood R‐βHB (Precision Xtra, Abbott Diabetes Care Inc., Almeda, CA, USA), glucose (Precision Xtra, Abbott Diabetes Care Inc.) and lactate (Lactate Plus, Nova Biomedical, Waltham, MA, USA) concentrations were measured at baseline, 3 h post energy bar ingestion, at 10‐min increments during exercise, and immediately following the TTE test. Samples were collected using a lancet following cleaning of the fingertip with an alcohol swab and then dried. The first droplet was wiped away with a cotton swab to remove any alcohol and the subsequent droplets were used for analysis. Blood sampling during exercise lasted ∼30–60 s – at each 10 min increment of exercise, the participant straddled the treadmill for a 1 min period to allow a capillary blood sample to be taken for subsequent blood R‐βHB, glucose and lactate analysis.

Buga A., Crabtree C.D., Stoner J.T., Decker D.D., Robinson B.T., Kackley M.L., Sapper T.N., Buxton J.D., D'Agostino D.P., McClure T.S., Berardi A., Cline S., Fleck T., Krout J., Newby D., Koutnik A.P., Volek J.S, & Prins P.J. (2023). Metabolic and ruck performance effects of a novel, light‐weight, energy‐dense ketogenic bar. Experimental Physiology, 108(5), 715-727.

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Measuring Metabolic Responses to Supplements

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Fingertip (capillary) blood samples for blood ketones (R-βHB; Precision Xtra, Abbott Diabetes Care Inc., Almeda, CA) and blood glucose (Precision Xtra, Abbott Diabetes Care Inc., Almeda, CA) concentrations were measured at baseline, 30 min post supplement ingestion (30 min; pre-cognitive test battery), 60 min post supplement ingestion (immediately before start of TT), immediately following the TT (+ 0 min), and 15 min following the TT (immediately following the cognitive test battery). Blood lactate concentration (Lactate Plus, Nova Biomedical) was assessed at baseline, 60 min post supplement ingestion, and immediately post exercise (+ 0 min). Samples were collected using a lancet following cleaning of the fingertip with an alcohol swab and then dried. The first droplet was wiped away with a cotton swab to remove any alcohol and the subsequent droplets were used for analysis.

Prins P.J., D’Agostino D.P., Rogers C.Q., Ault D.L., Welton G.L., Jones D.W., Henson S.R., Rothfuss T.J., Aiken K.G., Hose J.L., England E.L., Atwell A.D., Buxton J.D, & Koutnik A.P. (2020). Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters. Nutrition & Metabolism, 17, 81.

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Pharmacokinetic Evaluation of Ketone Levels

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This study’s pharmacokinetics evaluation was analyzed using the single-dose administration data. KB levels were measured using the finger-prick method by collecting capillary blood with a point-of-care blood ketone meter (precision xtra ™, Abbott) at each study visit (visit 2-7). This measurement allowed the detection of immediate changes in the blood KB levels. Glucose levels were assessed with a point-of-care blood glucose meter (precision xtra ™, Abbott), also allowing detection of immediate changes in the blood glucose. Additionally, HbA1c was assessed at each visit and analyzed at the laboratory of the USB. HbA1c represents the mean glucose levels over the last two to 3 months. Blood samples were immediately sent at room temperature to the inhouse laboratory of the University Hospital Basel for immediate analysis of HbA1c. HbA1c has the laboratory reference HbA1c 4.8%–5.9% (according to DCCT/NGSP).

Putananickal N., Gross E.C., Orsini A.L., Schmidt S., Hafner P., Gocheva V., Nagy S., Henzi B.C., Rubino D., Schädelin S., Sandor P, & Fischer D. (2023). Metabolic markers of short and long-term exogenous DL-beta-hydroxybutyrate supplementation in episodic migraine patients: an exploratory analysis of a randomized-controlled-trial. Frontiers in Pharmacology, 14, 1172483.

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Measuring serum BHB levels in mouse models

Cited 1 time

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Serum BHB levels were measured in DS mice as previously described [16 (link)]. Briefly, blood samples were collected from randomly selected P35–40 DS mice from each diet group. Animals were anesthetized with a ketamine/xylazine cocktail (87.5 mg/kg ketamine / 12.5 mg/kg xylazine, IP). Blood was sampled via cardiac puncture into an EDTA pre-coated syringe to prevent coagulation, and centrifuged at 3,500 rpm, 4°C, for 5 minutes to obtain plasma. BHB levels were determined in duplicate using a commercially available enzyme colorimetric BHB Assay kit (BioVision, Mountain View, CA). OD450 readings were determined using plate spectrophotometry (BioTek Synergy 4, Winooski, VT). Serum BHB levels were measured in DBA/1 mice using a test strip system and reader (Precision Xtra; Abbott Diabetes Care Inc., Alameda, CA, U.S.A.) from tail vein blood samples.

Crotts M.S., Kim Y., Bravo E., Richerson G.B, & Teran F.A. (2021). A ketogenic diet protects DBA/1 and Scn1aR1407X/+ mice against seizure-induced respiratory arrest independent of ketosis. Epilepsy & behavior : E&B, 124, 108334.

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Metabolic Blood Biomarker Profiling

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After overnight fast, ~200 µl whole blood was collected by submandibular vein lancet bleed (glucose) or brachial sinus puncture (remaining assays). One microliter whole blood was analyzed via glucometer (PrecisionXtra, Abbott Diabetes Care Inc., Alameda, CA, USA) and test strip (Abbott Diabetes Care Ltd., Witney, Oxon, UK). Blood collected in serum separator tubes for the remaining tests was incubated on ice for 90 min, and centrifuged at 1,600×g (20 min at 4°C). Insulin levels were measured using the Insulin Enzyme Immunoassay Kit (Cayman Chemical, Cat. #589501, Ann Arbor, MI 48108, USA) according to the manufacturer’s instructions as previously described [29 (link)]. Serum triglyceride and cholesterol levels were measured using an automated chemical analyzer (Vitro 350, OrthoClinical Diagnostics Company, Rochester, NY, USA).

He J., Quintana M.T., Sullivan J., L Parry T., J Grevengoed T., Schisler J.C., Hill J.A., Yates C.C., Mapanga R.F., Essop M.F., Stansfield W.E., Bain J.R., Newgard C.B., Muehlbauer M.J., Han Y., Clarke B.A, & Willis M.S. (2015). MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. Cardiovascular Diabetology, 14, 97.

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Comprehensive Metabolic Monitoring Protocol

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Blood glucose was measured with a glucometer (OneTouch Ultra; LifeScan, Milpitas, CA, Coefficient of Variation <5%) and albumin as well creatinine by an automated analyzer (Cobas Integra 400 plus, Roche Diagnostics, Indianapolis, IN). Using this analyzer glycated hemoglobin (HbA1c) in whole blood was also monitored. Ketone bodies in blood were measured with test strips (Precision Xtra; Abbott Diabetes Care, Alameda, CA).

Luippold G., Bedenik J., Voigt A, & Grempler R. (2016). Short- and Longterm Glycemic Control of Streptozotocin-Induced Diabetic Rats Using Different Insulin Preparations. PLoS ONE, 11(6), e0156346.

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Tail-Tip Blood Glucose Measurement

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Briefly, the tip of the tail was cut and 5 μl of blood were drawn directly in the glucose strip for the measurement (Precision Xtra, Abbott Diabetes Care Inc.).

Di Biase S., Shim H.S., Kim K.H., Vinciguerra M., Rappa F., Wei M., Brandhorst S., Cappello F., Mirzaei H., Lee C, & Longo V.D. (2017). Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biology, 15(3), e2001951.

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Monitoring Ketosis Progression in Mice

Cited 2 times

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In a subset of mice, BHB and glucose levels were measured at weaning prior to initiation of treatment to establish a baseline, then approximately 10 days throughout treatment until natural death (Kcna1-null mice) or termination for age-matched wild type (WT) controls. BHB and glucose levels were measured to verify ketosis as we and others have done from blood samples (50 µl) collected from the tail vein using a test strip system and reader (Precision Xtra; Abbott Diabetes Care Inc., Alameda, CA, U.S.A.)^{5 (link),6 (link)}.

Simeone K.A., Matthews S.A., Rho J.M, & Simeone T.A. (2016). Ketogenic Diet Treatment Increases Longevity in Kcna1-null Mice, a Model of Sudden Unexpected Death in Epilepsy. Epilepsia, 57(8), e178-e182.

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