Log In Sign up
The largest database of trusted experimental protocols

Lactel absorbable polymers

Manufactured by Durect
Visit Supplier
Sourced in United States

LACTEL Absorbable Polymers are a range of biodegradable and biocompatible polymers developed by Durect. These polymers are designed for use in various biomedical applications, including drug delivery systems and tissue engineering. The core function of LACTEL Absorbable Polymers is to provide a controlled and gradual release of active ingredients or to serve as a scaffold for cell growth and tissue regeneration.

Automatically generated - may contain errors

Lab products found in correlation

Methanol, by Thermo Fisher Scientific (2 mentions) Brain derived neurotrophic factor (bdnf), by Promega (1 mentions) Brain derived neurotrophic factor (bdnf), by Thermo Fisher Scientific (1 mentions) Tetracycline hydrochloride, by Merck Group (1 mentions) 1 1 1 3 3 3 hexafluoro 2 propanol hfp, by Merck Group (1 mentions) Chloroform, by Thermo Fisher Scientific (1 mentions) Hexamethyldisilazane, by Merck Group (1 mentions) Milli q ultrapure water system, by Merck Group (1 mentions) Beta cyclodextrin β cd, by Merck Group (1 mentions) Ascorbic acid, by Merck Group (1 mentions) β glycerophosphate, by Merck Group (1 mentions) Paraformaldehyde pfa, by Merck Group (1 mentions) Alexa fluor 647 cadaverine, by Thermo Fisher Scientific (1 mentions) Dspe peg mal, by Nanocs (1 mentions)

Close spelling variants of this product

Lactel (3 citations)

4 protocols using lactel absorbable polymers

1

Fabrication and Characterization of Polymeric Drug Delivery System

Check if the same lab product or an alternative is used in the 5 most similar protocols
PLGA was purchased from Sigma-Aldrich (50:50 lactide/glycolide, carboxy-terminated, molecular mass of 7 to 17 kD), and LACTEL Absorbable Polymers were purchased from Durect Corp. (50:50 lactide/glycolide, carboxy-terminated, 0.15 to 0.25 dl/g in hexafluoroisopropanol). Proteins were sourced as follows: SDF (R&D Systems), NT-3 (PeproTech), BDNF (PeproTech), and EPO (Janssen). Enzyme-linked immunosorbent assay (ELISA) kits for SDF and NT-3 were purchased from R&D Systems, and those for BDNF were purchased from Promega. All other materials were obtained as indicated.
Pakulska M.M., Elliott Donaghue I., Obermeyer J.M., Tuladhar A., McLaughlin C.K., Shendruk T.N, & Shoichet M.S. (2016). Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles. Science Advances, 2(5), e1600519.
+ Open protocol
+ Expand
2

Peri-implantitis Bacterial Cultures and Polymer Synthesis

Check if the same lab product or an alternative is used in the 5 most similar protocols
Four distinct peri-implantitis-associated Gram-negative anaerobic bacteria were selected for this study. Pg (ATCC 33277), Fn (ATCC 10953), Pi (ATCC 25611), and Aa (ATCC 33384) were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).
Poly(DL-lactide) (PLA, inherent viscosity: 0.55–0.75 dL/g in CHCl3) and poly(ε-caprolactone) (PCL, inherent viscosity: 1.29 dL/g in CHCl3) were purchased from Lactel Absorbable Polymers (Durect Corporation, Birmingham, AL, USA). Type-B Gelatin (GEL) from bovine skin (bloom no. 225), tetracycline hydrochloride (TCH, molecular weight [Mw] 480.90 g/mol), hexamethyldisilazane (HMDS), formaldehyde, and 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) were acquired from Sigma-Aldrich (Sigma-Aldrich Corporation, St. Louis, MO, USA). Brain heart infusion (BHI, Difco Laboratories Inc., Detroit, MI, USA) culture media containing 5 g/L yeast extract (BHI-YE, Difco Laboratories Inc., Detroit, MI, USA) with 5% v/v Vitamin K/hemin (Thermo Fisher Scientific, Inc., Pittsburgh, PA, USA) solution was used. Phosphate-buffered saline, ethanol, and blood agar plates supplemented with 5% sheep blood were obtained from Fisher Scientific Company LLC (Fair Lawn, NJ, USA).
Shahi R.G., Albuquerque M.T., Münchow E.A., Blanchard S.B., Gregory R.L, & Bottino M.C. (2016). Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating. Odontology, 105(3), 354-363.
+ Open protocol
+ Expand
3

Preparation of PLGA-Based Drug Delivery System

Check if the same lab product or an alternative is used in the 5 most similar protocols
Dexamethasone (DEX > 99%, Tokyo Chemical Industry Co., Ltd., Tokyo, Japan), beta-cyclodextrin (β-CD, Sigma-Aldrich, St. Louis, MO, USA), chloroform (> 99.8%, Alfa Aesar, Ward Hill, MA, USA), methanol (Thermo Fisher Scientific Inc., Hampton, NH, USA), 1,1,1,3,3,3 hexafluoroisopropanol (HFIP, 99%, Beantown Chemical Co., Hudson, NH, USA), Hexamethyldisilazane (> 99%, Sigma-Aldrich), hexcetylpyridinium chloride monohydrate (CPC, Sigma-Aldrich), β-glycerophosphate (Sigma-Aldrich), ascorbic acid (Sigma-Aldrich), paraformaldehyde (PFA, Sigma-Aldrich) and 75:25 poly(DL-lactide-co-glycolide acid) (PLGA, inherent viscosity: 0.55–0.75 dL/g in CHCl3, Lactel Absorbable Polymers, Durect Corporation, Birmingham, AL, USA) were purchased and used as-received. Distilled-deionized (DI) water from a Millipore Milli-Q ultrapure water system was used in the experiments.
Daghrery A., Aytac Z., Dubey N., Mei L., Schwendeman A, & Bottino M.C. (2020). Electrospinning of dexamethasone/cyclodextrin inclusion complex polymer fibers for dental pulp therapy. Colloids and surfaces. B, Biointerfaces, 191, 111011.
+ Open protocol
+ Expand
4

Synthesis and Characterization of Peptide-Conjugated Lipid-PEG and Cationic Dendrimer

Check if the same lab product or an alternative is used in the 5 most similar protocols
The S2P peptide–conjugated lipid-PEG was synthesized by conjugating CRTLTVRKC peptide (GLS Biochem Systems Inc., catalog no. 652358) to DSPE-PEG-Mal [PEG molecular weight (MW), 3.4 kDa; Nanocs Inc., catalog no. PG2-DSML-3k) via the free thiol of the C terminus using maleimide chemistry. The final products were washed and purified in cold methanol and characterized by 1H nuclear magnetic resonance (NMR). The cationic G0-C14 was synthesized from 1,2-epoxytetradecane (Sigma-Aldrich, catalog no. 260266) and PAMAM dendrimer G0 (Sigma-Aldrich, catalog no. 412368) at a molar ratio of 7:1 by a ring-opening reaction according to our previous reports (14 (link), 24 (link)). The fluorescent PLGA–Alexa 647 polymer was synthesized by coupling Alexa Fluor 647 Cadaverine (Thermo Fisher Scientific, catalog no. A30679) to the C terminus of 50:50 PLGA (inherent viscosity range of 0.55 to 0.75 dl/g, 43.4 kDa, LACTEL Absorbable Polymers by DURECT Corporation, catalog no. B6013–2).
Tao W., Yurdagul A J.r., Kong N., Li W., Wang X., Doran A.C., Feng C., Wang J., Islam M.A., Farokhzad O.C., Tabas I, & Shi J. (2020). siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice. Science translational medicine, 12(553), eaay1063.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!