B fc 1000 radiation

Manufactured by Bioscan

The B-FC-1000 is a radiation detection device. It is designed to measure and monitor radiation levels in various environments.

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Lab products found in correlation

Lc 2010a ht system, by Bioscan (2 mentions) Sterile filter, by Merck Group (1 mentions) Sep pak c18, by Waters Corporation (1 mentions) Solvents and reagents, by Merck Group (1 mentions) Nmr spectrometer, by Agilent Technologies (1 mentions)

Close spelling variants of this product

B-FC-1000 radiation detector B-FC-1000

2 protocols using b fc 1000 radiation

Radiolabeled Compound Synthesis and Purification

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Reagents and solvents were purchased from Aldrich Chemical or Fisher Scientific and were used without further purification unless noted. Chromatography columns for HPLC analysis and purification were purchased from Phenomenex or Waters. High performance liquid chromatography (HPLC) was performed using a Shimadzu LC-2010A HT system equipped with a Bioscan B- FC-1000 radiation detector. Sodium chloride, 0.9% USP and sterile water for Injection, USP were purchased from Hospira; Dehydrated Alcohol for Injection, USP was obtained from Akorn Inc. Sterile filters were acquired from Millipore; 10 cc sterile vials were obtained from Hollister-Stier; C18 sep-paks were purchased from Waters Corporation and were flushed with 10 ml of ethanol followed by 10 ml of sterile water prior to use. BCPP-EF reference standard 1 and labeling precursor 15 were synthesized in house. Detailed procedures are provided in the Supplementary Material.

Kaur T., Brooks A.F., Liddell K.M., Henderson B.D., Hockley B.G., Bohnen N.I., Albin R.L, & Scott P.J. (2022). Automated Synthesis of 18F-BCPP-EF {2-tert-Butyl-4-Chloro-5-{6-[2-(2[18F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2H-Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson’s Disease. Frontiers in Chemistry, 10, 878835.

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Chemical Characterization of Compounds

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All the chemicals employed in the syntheses were sourced commercially, and used without further purification. ¹H-Nuclear magnetic resonance (NMR) spectra were obtained at 400 MHz on Varian NMR spectrometer in CD₃OD or d₆-DMSO solutions at room temperature with tetramethylsilane (TMS, δ = 0) as an internal standard. ¹³C-NMR spectra were obtained at 100 MHz and ¹⁹F-NMR spectra were obtained at 376 MHz. Chemical shifts (δ) are reported in ppm and coupling constants are reported in Hertz. Multiplicity is defined by s (singlet), d (doublet), t (triplet), q (quartet) and m (multiplet). High performance liquid chromatography (HPLC) was performed using a Shimadzu LC-2010A HT system equipped with a Bioscan B-FC-1000 radiation detector. Mass spectra were performed on a Micromass VG 70-250-S Magnetic sector mass spectrometer, Micromass AutoSpec Ultima Magnetic sector mass spectrometer or Agilent Q-TOF HPLC-MS using the electrospray ionization (ESI) method or electron ionization (EI) method.

Cary B.P., Brooks A.F., Fawaz M.V., Drake L.R., Desmond T.J., Sherman P., Quesada C.A, & Scott P.J. (2016). Synthesis and Evaluation of [18F]RAGER: A First Generation Small-Molecule PET Radioligand Targeting the Receptor for Advanced Glycation Endproducts. ACS chemical neuroscience, 7(3), 391-398.

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