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6470 qqq mass spectrometer

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The Agilent 6470 QQQ mass spectrometer is a highly sensitive and selective analytical instrument used for the identification and quantification of a wide range of chemical compounds. It operates on the principle of triple quadrupole mass spectrometry, providing accurate and reliable results for applications in various industries, including pharmaceuticals, environmental analysis, and food testing.

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Lab products found in correlation

Cary 50 spectrometer, by Agilent Technologies (3 mentions) 550 sonic dismembrator, by Thermo Fisher Scientific (2 mentions) 1200 system, by Agilent Technologies (2 mentions) 1290 infinity 2 system, by Agilent Technologies (1 mentions) 1290 infinity 2 uhplc, by Agilent Technologies (1 mentions) Ajs esi source, by Agilent Technologies (1 mentions)

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Spectrometers (10 citations) 6470 Triple Quadrupole Mass Spectrometer (QqQ-MS), (2 citations)

4 protocols using 6470 qqq mass spectrometer

1

Characterization of E. coli Proteins

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UV-vis spectra were recorded on a Cary 50 spectrometer from Varian using the WinUV software package to control the instrument. Sonic disruption of E. coli was conducted with a 550 sonic dismembrator (Fisher Scientific, Waltham, MA) in an anaerobic chamber (Coy, Grass Lakes, MI). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was conducted as described previously.23 (link) Ultra-high-performance liquid chromatography with detection by tandem mass spectrometry (LC-MS/MS) was conducted on an Agilent Technologies 1200 system coupled to an Agilent Technologies 6470 QQQ mass spectrometer. The system was operated with the associated Mass Hunter software package, which was also used for data collection and analysis.
Wang B., Blaszczyk A., Knox H.L., Zhou S., Blaesi E.J., Krebs C., Wang R.X, & Booker S.J. (2018). Stereochemical and Mechanistic Investigation of the Reaction Catalyzed by Fom3 from Streptomyces fradiae, a Cobalamin-Dependent Radical S-Adenosylmethionine Methylase. Biochemistry, 57(33), 4972-4984.
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2

Characterization of E. coli Proteins

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UV-vis spectra were recorded on a Cary 50 spectrometer from Varian using the WinUV software package to control the instrument. Sonic disruption of E. coli was conducted with a 550 sonic dismembrator (Fisher Scientific, Waltham, MA) in an anaerobic chamber (Coy, Grass Lakes, MI). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was conducted as described previously.12 (link) Ultra-high-performance liquid chromatography with detection by tandem mass spectrometry (LC-MS/MS) was conducted on an Agilent Technologies 1200 system coupled to an Agilent Technologies 6470 QQQ mass spectrometer. The system was operated with the associated Mass Hunter software package, which was also used for data collection and analysis.
Blaszczyk A.J., Knox H.L, & Booker S.J. (2019). Understanding the Role of Electron Donors in the Reaction Catalyzed by TsrM, a Cobalamin-Dependent Radical S-Adenosylmethionine Methylase. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 24(6), 831-839.
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3

UV-Vis Spectra and UPLC-MS/MS Analysis

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UV–vis spectra were recorded
on a Varian Cary 50 spectrometer (Walnut Creek, CA) using the WinUV
software package to control the instrument. Ultraperformance liquid
chromatography (UPLC) was conducted on an Agilent Technologies 1290
Infinity II system coupled to an Agilent Technologies 6470 QQQ mass
spectrometer (Santa Clara, CA) with detection by tandem mass spectrometry
(MS/MS). Data collection and analysis were performed using the associated
MassHunter software package.
Warui D.M., Sil D., Lee K.H., Neti S.S., Esakova O.A., Knox H.L., Krebs C, & Booker S.J. (2022). In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1. ACS Bio & Med Chem Au, 2(5), 456-468.
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4

Targeted Lipidomics Using UHPLC-QQQ-MS

Cited 1 time
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Targeted lipidomics was performed on a 1290 Infinity II UHPLC coupled to a 6470 QQQ mass spectrometer via AJS ESI source (Agilent) in positive ionization mode, using a scheduled multiple reaction monitoring (MRM) method76 (link). The MRM transition list contained 20 lipid classes and 593 lipid species (excluding internal standards CUDA and SPLASH Lipidomix). Skyline-daily software was used for lipid species assignment77 (link). A lipid set enrichment analysis was performed by ranking fold changes, calculating enrichment scores and estimating the significance of enrichment using a permutation algorithm78 (link). The Supplementary Note contains detailed descriptions of the procedure.
Bruedigam C., Porter A.H., Song A., Vroeg in de Wei G., Stoll T., Straube J., Cooper L., Cheng G., Kahl V.F., Sobinoff A.P., Ling V.Y., Jebaraj B.M., Janardhanan Y., Haldar R., Bray L.J., Bullinger L., Heidel F.H., Kennedy G.A., Hill M.M., Pickett H.A., Abdel-Wahab O., Hartel G, & Lane S.W. (2023). Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia. Nature Cancer, 5(1), 47-65.
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