All behavioral experiments were performed in adult female mice (10–12 weeks old). They were bred and maintained on a 12/12 h light/dark cycle (lights on at 7 A.M.) and received food ad libitum. Genotypes used were CBA/CaJ, C57BL/6J, Mecp2Heterozygous (B6.129P2(C)-Mecp2tm1.1Bird/J) and Mecp2WT-siblings (Guy et al., 2001 (link)) (The Jackson Laboratory). Ten to twelve week old Mecp2Heterozygous mice in this study do not show overt motor or jaw/mouth phenotypes that would preclude performing the pup retrieval assay (Krishnan et al., 2017 (link)). All procedures were conducted in accordance with the National Institutes of Health’s Guide for the Care and Use of Laboratory Animals and approved by the University of Tennessee-Knoxville Institutional Animal Care and Use Committee.
Mecp2heterozygous b6.129p2 c mecp2tm1 1bird j
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The Mecp2Heterozygous (B6.129P2(C)-Mecp2tm1.1Bird/J) is a mouse model with a targeted mutation in the Mecp2 gene. This model is heterozygous for the mutation, meaning one allele of the Mecp2 gene is mutated while the other is normal. The core function of this model is to enable research on Rett syndrome, a neurodevelopmental disorder primarily affecting females.
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2 protocols using mecp2heterozygous b6.129p2 c mecp2tm1 1bird j
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Pup Retrieval Assay in Mecp2 Mice
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Behavioral Experiments in Mecp2 Mice
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All behavioral experiments were performed in adult female mice (10-12 weeks old). They were bred and maintained on a 12/12 h light/dark cycle (lights on at 7 A.M.) and received food ad libitum. Genotypes used were CBA/CaJ, C57BL/6J, Mecp2 Heterozygous (B6.129P2(C)-Mecp2 tm1.1Bird /J) and Mecp2 WTsiblings (Guy et al., 2001) (The Jackson Laboratory). Mecp2 Heterozygous mice are considered presymptomatic at this age (Krishnan et al., 2017) . All procedures were conducted in accordance with the National Institutes of Health's Guide for the Care and Use of Laboratory Animals and approved by the University of Tennessee-Knoxville Institutional Animal Care and Use Committee.
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