Ltq orbitrap xl elite system

All reagents and solvents were purchased from commercial sources (Sigma-Aldrich, VWR, and Fisher Scientific, etc.) and used without further purification. Proton, carbon, and fluorine nuclear magnetic resonance (¹H, ¹³C, and ¹⁹F NMR) spectra were recorded on an Agilent 400 or 600 MHz spectrometer (A400a, A400c, A600a). Chemical shifts are reported in parts per million (ppm), with either the solvent resonance or tetramethyl silane (TMS) as the internal standard (TMS, 0 ppm; CDCl₃, 7.26 ppm; DMSO-d₆, 2.49 ppm in ¹H NMR and CDCl₃, 77.0 ppm; DMSO-d₆, 39.7 ppm in ¹³C NMR). Multiplicities are indicated as s (singlet), d (doublet), t (triplet), q (quartet), quint (quintet), m (multiplet); coupling constants J are given in hertz (Hz). High resolution mass spectrometry (HRMS) was performed with a Thermo Scientific LTQ-Orbitrap XL Elite system. All chemicals used in this study were of ≥95% purity based on HPLC, LC−MS, or NMR.

All reagents and solvents were purchased from commercial sources (Sigma-Aldrich, VWR, and Fisher Scientific) and used without further purification. Proton, carbon, and fluorine nuclear magnetic resonance (¹H, ¹³C, and ¹⁹F NMR) spectra were recorded on an Agilent 400 MHz or 600 MHz spectrometer (A400a, A400c, or A600a). Chemical shifts are reported in parts per million (ppm), with the solvent resonance as the internal standard (CDCl₃: 7.26 ppm; DMSO-d₆:2.49 ppm in ¹H NMR, and CDCl₃: 77.0 ppm; DMSO-d₆:39.7 ppm in ¹³C NMR). Multiplicities are indicated as s (singlet), d (doublet), t (triplet), q (quartet), quint (quintet), or m (multiplet), with the coupling constant (J) given in hertz (Hz). High-resolution mass spectrometry (HRMS) was performed with a Thermo Scientific LTQ-Orbitrap XL Elite system.