Sta liatest d dimer

Manufactured by Diagnostica Stago

Sourced in France

The STA Liatest D-dimer is a laboratory equipment product manufactured by Diagnostica Stago. It is used for the quantitative determination of D-dimer in human plasma.

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Lab products found in correlation

Coapresta 2000, by Sekisui (2 mentions) Sta liatest vwf, by Diagnostica Stago (1 mentions) Hemosil d dimer hs, by Werfen (1 mentions) Vidas d dimer exclusion, by bioMérieux (1 mentions) Cobas h232, by Roche (1 mentions) Hemosil d dimer hs 500, by Werfen (1 mentions) Innovance d dimer, by Siemens (1 mentions)

5 protocols using sta liatest d dimer

Quantitative D-dimer Measurement Protocol

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D-dimers were measured in all included patients. Plasma D-dimer was quantitatively measured using a latex agglutination test (STA Liatest D-dimer, Diagnostica Stago, Asnieres-sur-Seine, France). Citrate plasma for D-dimer estimation was obtained by centrifuging at 3500 rpm for 10 minutes. An elevated D-dimer level was defined as ≥ 0.5 mg/L.¹⁰ (link)

Nickel C.H., Kellett J., Cooksley T., Lyngholm L.E., Chang S., Imfeld S., Bingisser R, & Brabrand M. (2020). The Diagnoses and Outcomes of Emergency Patients With an Elevated D-Dimer Over the Next 90 Days. The American Journal of Medicine, 134(2), 260-266.e2.

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Evaluating D-dimer Levels for VTE Diagnosis

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The plasma level of D-dimer was measured with the commercially available NANOPIA^® latex agglutination assay kit (Sekisui Medical Company Limited, Tokyo, Japan), based on the same method commonly used for D-dimer assays such as the STA-Liatest D-dimer (Diagnostica Stago, Asnières, France), which contains latex microparticles coated with a monoclonal antibody specific for fragment D–D, in combination with an automated coagulation analyzer, the COAPRESTA 2000 (Sekisui Medical Co., Ltd., Tokyo, Japan).21 (link),22 (link) Concentrations were expressed in micrograms per milliliter (μg/mL), with a D-dimer level ≥1.0 μg/mL representing a positive result. With a cut-off value of 1.0 μg/mL, the sensitivity of the NANOPIA kit for diagnosing VTE was 99.6%.22 (link)

Yoshizawa K., Takeshima M., Ishino S., Ogasawara M., Fujiwara D., Itoh Y., Imanishi A., Ohta H, & Mishima K. (2021). Severity of Depressive Symptoms is Associated with Venous Thromboembolism in Hospitalized Patients with a Major Depressive Episode. Neuropsychiatric Disease and Treatment, 17, 2955-2963.

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Multivariate Biomarker Assay Protocol

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A Randox Evidence Investigator Biochip multiple immunoassay system (Randox Laboratories Ltd, Co Antrim, UK) using Li Hep plasma simultaneously measured biomarkers via two panels: Cerebral Array I consisted of IL-6, hFABP and BDNF and Cerebral Array II consisted of CRP, NGAL, sTNFR-1, NSE and TM . All assays underwent reproducibility studies using an internal control of pooled normal Li Hep plasma in addition to manufacturers control materials. Levels of fibrinogen by the Clauss clotting method and D-dimer and VWF antigen by immunoturbidometric assays were measured in citrated plasma using an automated coagulation analyser STA (Sta-Liatest VWF and Sta-Liatest D-Dimer, Diagnostica Stago, Asniers, France). These assays had well defined internal quality control and external control through participation in national quality assurance schemes. Commercial ELISA kits were used to assay human P-selectin (R&D Systems, UK) and PZ (Diagnostica Stago, France). Serum samples were used for anti PC antibodies (CVDefine^R, Athera Biotechnologies AB, Stockholm, Sweden), adhering to manufacturers recommendations. The intra- and inter coefficients of variation (CV %) of each assay are shown in Table 1. All assays were performed blind to study status.

Segal H.C., Burgess A.I., Poole D.L., Mehta Z., Silver L.E, & Rothwell P.M. (2014). Population-based study of blood biomarkers in prediction of sub-acute recurrent stroke. Stroke, 45(10), 2912-2917.

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D-dimer Assay Cutoffs for VTE Risk

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D-dimer concentrations were assessed with the quantitative assay routinely used in each participating center, provided it was one of the following: Cobas h232 (Roche Diagnostics; Switzerland), HemosIL D-dimer HS 500 (Instrumentation Laboratory; Milan, Italy), HemosIL D-dimer HS (Instrumentation Laboratory), HemosIL D-dimer (Instrumentation Laboratory), Innovance D-DIMER (Siemens; Deerfield, IL), Sclavo Auto D-dimer (Dasit; Milan, Italy), STA Liatest D-dimer (Diagnostica Stago; Asnieres-sur-Seine, France), and VIDAS D-dimer Exclusion (bioMerieux; Lyon, France). For the assays expressing results as fibrinogen equivalent units, the cutoffs were 350 ng/mL and 500 ng/mL for males and females, respectively; the cutoffs for assays expressing the results as D-dimer units were 175 ng/mL and 250 ng/mL for males and females, respectively. These cutoffs were selected by the study team after a critical evaluation of the Dulcis study results,⁷ (link) taking into account that (1) patients aged ≥75 years were excluded from the present study (and therefore, there was no need for different cutoff levels according to the age) and (2) male patients are unanimously recognized at higher risk of recurrence than females (for this reason the decided cutoff level was lower for males than females).

Palareti G., Poli D., Ageno W., Legnani C., Antonucci E., Bucherini E., Testa S., Paoletti O., Chistolini A., Serrao A., Martinelli I., Bucciarelli P., Falanga A., Tosetto A., Sarti L., Mastroiacovo D., Cosmi B., Visonà A., Santoro R.C., Zanatta N., Grandone E., Bertù L., Pengo V., Caiano L, & Prandoni P. (2022). D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study. Blood Advances, 6(23), 6005-6015.

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Measuring Plasma D-dimer with NANOPIA Assay

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D-dimer plasma concentrations were measured with the commercially available NANOPIA^® latex agglutination assay kit (Sekisui Medical Company Limited, Tokyo, Japan), based on the same method commonly used for D-dimer assays such as the STA-Liatest D-dimer (Diagnostica Stago, Asnières, France) that contains latex microparticles coated with a monoclonal antibody specific for fragment DD, in combination with an automated coagulation analyzer, the COAPRESTA 2000 (Sekisui Medical Co., Ltd., Tokyo, Japan).28 (link),29 (link) Concentrations were expressed in micrograms per milliliter (μg/mL), with a D-dimer level ≥1.0 μg/mL representing a positive result. With a cut-off value of 1 μg/mL, the sensitivity of NANOPIA D-dimer in diagnosing VTE was 99.6%.28 (link)

Takeshima M., Ishikawa H., Umeta Y., Kudoh M., Umakoshi A., Yoshizawa K., Ito Y., Hosoya T., Tsutsui K., Ohta H, & Mishima K. (2020). Prevalence of Asymptomatic Venous Thromboembolism in Depressive Inpatients. Neuropsychiatric Disease and Treatment, 16, 579-587.

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