Gen 2 assay

Manufactured by Beckman Coulter

The Gen II Assay is a laboratory equipment product from Beckman Coulter. It is designed to perform various assays, which are analytical procedures used to detect and measure specific substances in a sample. The core function of the Gen II Assay is to facilitate the analysis and quantification of target analytes in a sample, though its specific intended use is not provided.

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Lab products found in correlation

Picoamh assay, by Ansh Labs (1 mentions) Amh gen 2 assay, by Beckman Coulter (1 mentions) Cobas e601, by Roche (1 mentions)

Spelling variants of this product

AMH Gen II assay (11 citations) AMH Gen II Elisa assay kit (3 citations) AMH Gen II ELISA assay (3 citations) Gen II (2 citations) AMH Gen II enzyme-linked immunosorbent assay (ELISA) (2 citations)

3 protocols using gen 2 assay

Serum AMH Levels Conversion Protocol

Cited 1 time

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Serum AMH levels in patients were compared with a group of healthy controls. This international reference cohort existed of 554 healthy adult women, aged 18–47 years, who had a regular menstrual cycle and/or were proven fertile.^{26 (link)} AMH levels in controls were originally reported as measured by the Beckman Coulter Gen II Assay. Therefore, a conversion factor was used to compare AMH levels in the patient group to those in the controls^{25 (link)}:

AMH(picoAMH assay in ng mL) =(1.45*AMHGenII)+0.32.

Brouwer J., Dolhain R.J., Hazes J.M., Erler N.S., Visser J.A, & Laven J.S. (2020). Decline of ovarian function in patients with rheumatoid arthritis: serum anti-Müllerian hormone levels in a longitudinal cohort. RMD Open, 6(3), e001307.

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Verifying AMH Assay Discrepancies

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A recent case report suggested that the amino acid substitution corresponding to rs10417628 (AMH locus) reduces AMH detection by the picoAMH assay from Ansh Labs without influencing AMH bioactivity (Hoyos et al., 2020 (link)). We sought to verify this finding in a subsample of the Doetinchem Cohort Study, for which AMH was measured using both the picoAMH assay and the less sensitive Gen II assay from Beckman Coulter. In addition, we requested median AMH levels across rs10417628 genotype categories from both ALSPAC mothers and daughters, because ALSPAC also used the AMH Gen II assay from Beckman Coulter.

Verdiesen R.M., van der Schouw Y.T., van Gils C.H., Verschuren W.M., Broekmans F.J., Borges M.C., Gonçalves Soares A.L., Lawlor D.A., Eliassen A.H., Kraft P., Sandler D.P., Harlow S.D., Smith J.A., Santoro N., Schoemaker M.J., Swerdlow A.J., Murray A., Ruth K.S, & Onland-Moret N.C. (2022). Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women. Human Reproduction (Oxford, England), 37(5), 1069-1082.

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Hormone Measurement Assays Protocol

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Up to March 2008 LH, FSH, estradiol and TSH levels were measured by chemilu-minescence immunoassay (Siemens Bayer Advia Centaur CP Immunoassay). Since March 2008 LH, FSH, estradiol and TSH were measured by electrochemiluminescence immunoassay (Roche Cobas E 601, module immunology analyzer). SHBG levels were measured by chemiluminescence immunoassay (Siemens Bayer Advia Centaur CP Immunoassay) up to November 2010 and since then by electrochemiluminescence immunoassay (Roche Cobas E 601, module immunology analyzer). Serum levels of Inhibin B were measured by the Beckman Coulter GenII assay.

Sømod M.E., Vestergaard E.T., Kristensen K, & Birkebæk N.H. (2016). Increasing incidence of premature thelarche in the Central Region of Denmark - Challenges in differentiating girls less than 7 years of age with premature thelarche from girls with precocious puberty in real-life practice. International Journal of Pediatric Endocrinology, 2016, 4.

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