Symbia spect ct system

Patients were referred to the Department of Nuclear Medicine after the administration of ^99mTc-HSA. SPECT/CT images were acquired on a Symbia™ SPECT/CT system (Siemens Healthcare, Erlangen, Germany) on average 60 minutes after the injection of ^99mTc-HSA. Imaging parameters were as follows: matrix of 128x128 with 128 frames (25s/frame), CT: 128 kV, 17 mAs, slice thickness: 5 mm, image reconstruction with a medium smooth kernel. SPECT images were visualized in 3 orthogonal planes and were corrected for attenuation and scatter. Fusion images were created from the co-registered SPECT and low-dose CT images using the e.soft™ 2007 application package (Siemens Healthcare, Erlangen, Germany). Extrahepatic tracer accumulation was evaluated by specialists in nuclear medicine and board certified radiologists in consensus during the following weekly tumor board at our institution.

SPECT/CT images were acquired using a Symbia SPECT/CT system (Siemens Healthcare, Erlangen, Germany) 60 minutes after ^99mTc-HSAM administration. Unenhanced low dose computed tomography was acquired at 128 kV and 17 mAs and reconstructed with 5 mm slice thickness. For SPECT 128 frames (25 s/frame) were collected with a 128 × 128 matrix and attenuation and scatter slices were reconstructed iteratively. The fusion images were computed via e.soft 2007 application package (Siemens Healthcare, Erlangen, Germany). In the subsequent qualitative visual analysis any noticeable tracer accumulation in the anterior abdominal wall or in the falciform ligament was registered. In cases with an apparent tracer uptake in these locations strategies to reduce the risk for non-targeted 90-yttrium diversion to the abdominal wall were evaluated.

All enrolled patients underwent whole-body imaging at six time points after drug administration: 0.5 h (before urination), 4 h, 1 day, 3 days, 5 days and 7 days after injection. Planar acquisitions were performed with a dual-head Symbia SPECT/CT system (Symbia T16, Siemens, Germany) in the supine position using high-energy parallel-hole collimator with a 20% energy window located at the center of the 208 keV photopeak. Continuous acquisition was performed at a scan speed of 10 cm/min and a 1024 × 256 matrix. Three-dimensional SPECT/CT acquisitions were performed with a single field-of-view cantered on the abdomen (including the liver and kidney) using 32 camera steps of 15 s each and an image matrix of 128 × 128 voxels (voxel spacing, 2 mm, the slice thickness, 2 mm).