The morning after each 177Lu-DOTATATE administration, a post-treatment scintigraphy including a whole-body planar image (16 cm/min) and an abdominal SPECT/CT was performed on a Symbia Intevo Bold system (Siemens Healthineers, Erlangen, Germany). Two protocols were used successively in the department for the quantitative SPECT acquisition:
Symbia intevo bold system
Manufactured by Siemens
Sourced in Germany
The Symbia Intevo Bold system is a single-photon emission computed tomography (SPECT) imaging device manufactured by Siemens. It is designed to produce high-quality images of the internal structures and functions of the human body. The system uses gamma rays to create detailed 3D images, which can be used by healthcare professionals for diagnostic purposes.
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Lab products found in correlation
3 protocols using symbia intevo bold system
1
Quantitative SPECT Imaging After 177Lu-DOTATATE
2
Radioligand Therapy Imaging Protocol
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Patients received [68Ga]Ga-PSMA-11-PET/CT imaging approximately one week prior to radioligand therapy. Imaging was performed 60 ± 10 min post-injection (p.i.) on a Biograph mCT system (Siemens Healthineers, Erlangen, Germany) scanning cranium to trochanter major. In this study, these scans were solely used to determine lesion volumes.
After therapy, SPECT/CT and planar imaging was performed at 1, 24, 48, 72 and 168 h on either a Symbia T16 or Symbia Intevo Bold system (Siemens Healthineers, Erlangen, Germany). SPECT/CT scans were acquired at three body regions to include lesions and organs at risk: the pelvis, abdomen, and head-neck region. Acquisition and reconstruction parameters of PET/CT, SPECT/CT and planar imaging can be found in Additional file1 .
After therapy, SPECT/CT and planar imaging was performed at 1, 24, 48, 72 and 168 h on either a Symbia T16 or Symbia Intevo Bold system (Siemens Healthineers, Erlangen, Germany). SPECT/CT scans were acquired at three body regions to include lesions and organs at risk: the pelvis, abdomen, and head-neck region. Acquisition and reconstruction parameters of PET/CT, SPECT/CT and planar imaging can be found in Additional file
3
Quantitative PET/CT and SPECT/CT Imaging
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All PET/CT scans were obtained on a Biograph mCT device (mCT 128 Flow Edge; Siemens). Imaging started with a low-dose nonenhanced CT scan (120 kV, tube current modulation, pitch of 1.2, slice thickness of 5.0 mm) for attenuation correction followed by a wholebody PET scan from the base of the skull to the mid thigh. Reconstruction was conducted with an ordered-subset expectation maximization algorithm with 4 iterations and 12 subsets and gaussian-filtered to a transaxial resolution of 5 mm in full width at half maximum.
Quantitative SPECT/CT images (xSPECT; Siemens) were acquired at 24, 48, and 168 h after application of 177 Lu-PSMA-I&T on a Symbia Intevo Bold system (Siemens). The same time points were chosen for each therapy cycle. If no lesions in the head region were of interest for dosimetry, images of the thorax and abdomen were acquired at 2 bed positions. For attenuation correction, a low-dose CT scan (110 kV, 30 mAs, pitch of 1.5, slice thickness of 3.0 mm) was acquired alongside each SPECT scan. The SPECT images were reconstructed with an ordered-subset conjugate gradient maximization algorithm. For quantitative imaging, the device was regularly calibrated for 177 Lu according to the manufacturer's protocol.
Quantitative SPECT/CT images (xSPECT; Siemens) were acquired at 24, 48, and 168 h after application of 177 Lu-PSMA-I&T on a Symbia Intevo Bold system (Siemens). The same time points were chosen for each therapy cycle. If no lesions in the head region were of interest for dosimetry, images of the thorax and abdomen were acquired at 2 bed positions. For attenuation correction, a low-dose CT scan (110 kV, 30 mAs, pitch of 1.5, slice thickness of 3.0 mm) was acquired alongside each SPECT scan. The SPECT images were reconstructed with an ordered-subset conjugate gradient maximization algorithm. For quantitative imaging, the device was regularly calibrated for 177 Lu according to the manufacturer's protocol.
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