E501 module analyser

Manufactured by Roche

Sourced in France

The E501 Module Analyser is a diagnostic instrument designed for clinical laboratory use. It is a core component of Roche's analytical platform, providing automated processing and analysis of samples. The E501 Module Analyser performs various clinical chemistry and immunochemistry tests to support patient care and disease management.

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Lab products found in correlation

Cobas 6000, by Roche (2 mentions) Immulite 2000 il 6, by Siemens (2 mentions) Xn 1000 analyzer, by Sysmex (1 mentions)

3 protocols using e501 module analyser

Biomarker Profiling of ICU Admissions

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Plasma samples for biomarker profiling were collected as close as possible to the moment of ICU admission, and always within the first 12 h. Plasma MR-proADM measurement was performed by TRACE technology (Time Resolved Amplified Cryptate Emission) using a new sandwich immunoassay (Kryptor Compact Plus Analyser, BRAHMS, Hennigsdorf, Germany); limit of detection 0.05 nmol/L. PCT measurement was performed by electrochemiluminescence immunoassay (ECLIA) on a chemistry analyser (Cobas 6000, Roche Diagnostics, Meylan, France); limit of detection 0.02 ng/ml. Serum CRP and lactate were measured by particle-enhanced immunoturbidimetric and colorimetric assay, respectively (e501 Module Analyser, Roche Diagnostics, Meylan, France); limit of detection 0.15 mg/dL and 0.2 mmol/L, respectively.

Andaluz-Ojeda D., Nguyen H.B., Meunier-Beillard N., Cicuéndez R., Quenot J.P., Calvo D., Dargent A., Zarca E., Andrés C., Nogales L., Eiros J.M., Tamayo E., Gandía F., Bermejo-Martín J.F, & Charles P.E. (2017). Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity. Annals of Intensive Care, 7, 15.

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Comprehensive Clinical Laboratory Analysis

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We carried out all tests at our certified clinical laboratory (ISO 9001:2015). White blood cells, lymphocyte, and monocyte counts were performed on Sysmex XN-1000® analyzer using the manufacture's reagents (Sysmex Corporation, Japan). Alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), LDL-c, HDL-c, TC, and TG were tested on Roche Cobas 8100 sampling system analyzer (Module Cobas® c 702, Roche Diagnostics, Switzerland) using manufacture's reagents. The methodology for direct LDL-c, HDL-c, and TC methods are based on a standard homogeneous enzymatic colorimetric assay. We tested interleukin 6 (IL6) on IMMULITE® 2000 immunoassay system using the manufacture's luminescent immunoassay reagents (IMMULITE® 2000 IL6, Siemens Healthcare Diagnostic, Germany). Procalcitonin (PCT) measurement in plasma was performed by electrochemiluminescence immunoassay on a chemistry analyzer (Cobas 6000, Roche Diagnostics) limit of detection, as below 0.02 ng/ml. We measured serum C-reactive protein (CRP) by particle enhanced immunoturbidimetric (e501 Module Analyser, Roche Diagnostics). The limit of detection was set below 0.3 mg/L.

Aparisi Á., Iglesias-Echeverría C., Ybarra-Falcón C., Cusácovich I., Uribarri A., García-Gómez M., Ladrón R., Fuertes R., Candela J., Tobar J., Hinojosa W., Dueñas C., González R., Nogales L., Calvo D., Carrasco-Moraleja M., San Román J.A., Amat-Santos I.J, & Andaluz-Ojeda D. (2021). Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19. Nutrition, Metabolism, and Cardiovascular Diseases, 31(9), 2619-2627.

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Biomarker Profiling in Clinical Laboratory

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We carried out all tests at a certified clinical laboratory (ISO 9001:2015). Ferritin and serum high-sensitivity C-reactive protein (hs-CRP) were measured by particle enhanced immunoturbidimetric and colorimetric assay, respectively (e501 Module Analyser^®, Roche Diagnostics, Basel, Switzerland). Interleukin-6 (IL-6) was tested on IMMULITE^® 2000 immunoassay system (IMMULITE^® 2000 IL-6, Siemens Healthcare Diagnostic, Marburg, Germany). Quantification of biomarkers, such as the N-terminal prohormone of brain natriuretic peptide (NT-ProBNP) and the high-sensitivity T troponin (hs TnT) in plasma, were measured by electrochemiluminescence immunoassay with the analyzer Cobas^® 6000 c 601 (Roche Diagnostics, Basel, Switzerland). D-dimer was obtained by a turbidimetric test with the ACL Top 500^® hemostasis testing system (Werfen Company, Cuenca, Spain).

Aparisi Á., Ybarra-Falcón C., García-Gómez M., Tobar J., Iglesias-Echeverría C., Jaurrieta-Largo S., Ladrón R., Uribarri A., Catalá P., Hinojosa W., Marcos-Mangas M., Fernández-Prieto L., Sedano-Gutiérrez R., Cusacovich I., Andaluz-Ojeda D., de Vega-Sánchez B., Recio-Platero A., Sanz-Patiño E., Calvo D., Baladrón C., Carrasco-Moraleja M., Disdier-Vicente C., Amat-Santos I.J, & San Román J.A. (2021). Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective Evaluation. Journal of Clinical Medicine, 10(12), 2591.

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