1 2 distearoyl sn glycero 3 phosphoethanolamine n carboxy polyethylene glycol 2000 dspe peg2000 cooh

Manufactured by Avanti Polar Lipids

Sourced in Canada

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy (polyethylene glycol) 2000 (DSPE–PEG2000–COOH) is a lipid-based compound with a polyethylene glycol (PEG) moiety and a carboxyl group. It is used as a component in the formulation of liposomes and other lipid-based drug delivery systems.

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DSPE-PEG2000 (149 citations) DSPE-PEG2000-COOH (6 citations)

3 protocols using 1 2 distearoyl sn glycero 3 phosphoethanolamine n carboxy polyethylene glycol 2000 dspe peg2000 cooh

Nanoparticle-Mediated Combination Therapy

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1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy (polyethylene glycol) 2000 (DSPE–PEG2000–COOH) and the cross-linkable lipid (1-palmitoyl-2-(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine) (PTPC) were obtained from Avanti Polar Lipids (Alabaster, AL). Docetaxel (Dtxl), wortmannin (Wtmn), etoposide and gemcitabine hydrochloride were purchased from Sigma-Aldrich (St. Louis, MO). Olaparib was purchased from Selleckchem (Houston, TX). PLGA (poly(D,L-lactide-co-glycolide)) with a 50 : 50 monomer ratio, ester terminated, and viscosity of 0.72–0.92 dl g⁻¹ was purchased from Durect Corporation (Pelham, AL). Soybean lecithin consisting of 90–95% phosphatidylcholine was obtained from MP Biomedicals (Solon, OH). 200 Proof Ethanol (Molecular Biology Grade) and Acetonitrile (HPLC Grade) were purchased from Fisher Scientific (Hampton, NH). Dulbeco’s Phosphate Buffer Saline (PBS, 1X) was purchased from Gibco by Life Technologies (Carlsbad, CA). H460, H23 and H69AR cell lines were purchased from UNC’s Lineberger tissue culture facility.

Caster J.M., Sethi M., Kowalczyk S., Wang E., Tian X., Hyder S.N., Wagner K.T., Zhang Y.A., Kapadia C., Au K.M, & Wang A.Z. (2015). Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity. Nanoscale, 7(6), 2805-2811.

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Lipid-Based Nanoparticle Formulation for BDNF Delivery

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1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol) 2000] (DSPE-PEG2000-COOH), 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2 Dioleoyl-3-trimethylammoniumpropane chloride (DOTAP) were purchased from Avanti Polar Lipids (Alabaster, Alabama). Poly-L-arginine hydrochloride (molecular weight = 13,300 Da), holo-Transferrin human (Transferrin), 3β-Hydroxy-5-cholestene (Cholesterol), N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC), and N-Hydroxysuccinimide (NHS) were procured from Sigma-Aldrich Company (Darmstadt, Germany). The fluorescent dye 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocarbocyanine iodide (DiR) was obtained from Invitrogen (Landsmeer, Netherlands). BDNF (NM_012513) Rat Untagged plasmid was purchased from Origene (OriGene Technologies GmbH, Germany). All other chemicals used in this study were of analytical reagent grade.

Diniz D.M., Franzé S., & Homberg J.R. (2020). Crossing the Blood-Brain-Barrier: A bifunctional liposome for BDNF gene delivery – A Pilot Study.

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Fabrication of Hybrid Nanostructures

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Si wafers (p-type, 100) were purchased from Hissan (South Korea), and AZ GXR-601 (46 cps) photoresist (PR) was purchased from Merck (Germany). Polybutadiene-b-polyethyleneoxide (PBd-PEO; Mn: 1200 for PBd and 600 for PEO) and rhodamine-terminated PBd-PEO were purchased from Polymer Source (Canada), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (DSPE-PEG2000-COOH) was purchased from Avanti Polar Lipids (USA). Polydimethylsiloxane (PDMS) was purchased from Dow Corning (USA) and used by mixing the base and curing agent at a ratio of 10:1. Hexamethyldisilazane (HMDS), perfluorooctyltrichlorosilane (PFOTS), perfluorodecyltrichlorosilane (PFDTS), perfluorododecyltrichlorosilane (PFDDTS), poly(ethylene glycol) diacrylate (PEGDMA; Mn: 1000), 2-hydroxy-2-methyl-propiophenone, poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (Poloxamer 188) solution, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), fluorodeoxyglucose (FDG), sucrose, isopropyl β-D-1-thiogalactopyranoside (IPTG), sarkosyl, β-mercaptoethanol, glycerol, imidazole, fluorescein isothiocyanate (FITC), β-galactosidase (β-ga), and all solvents were purchased from Sigma-Aldrich (USA) and used as received.

Kang D.H., Han W.B., Il Ryu H., Kim N.H., Kim T.Y., Choi N., Kang J.Y., Yu Y.G, & Kim T.S. (2022). Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array. Nature Communications, 13, 1261.

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