Sodium hyaluronate

Manufactured by Sanofi

Sourced in United States

Sodium hyaluronate is a naturally occurring polysaccharide found in various connective tissues. It is a key component of the extracellular matrix and plays a crucial role in maintaining tissue hydration and lubrication. As a laboratory product, sodium hyaluronate can be used in various applications that require a biocompatible, viscoelastic, and lubricating material.

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Lab products found in correlation

Macrogol 15 hydroxystearate, by BASF (1 mentions) Dulbecco s modified eagle s medium dmem, by Thermo Fisher Scientific (1 mentions) Sodium hyaluronate, by Lifecore Biomedical (1 mentions)

2 protocols using sodium hyaluronate

Hyaluronic Acid-Based Nanocarrier Formulation

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Sodium hyaluronate (Mw = 200 KDa) was provided by Sanofi Genzyme, USA. Caprylic/capric triglyceride (Miglyol®812) was a kind gift from Cremer, Germany. Polyoxyethylene sorbitan monooleate (Tween®80), hexadecyltrimethylammonium bromide (CTAB), Nile Red, DAPI and plasma (from human) were purchased from Sigma-Aldrich, Spain. Macrogol 15 hydroxystearate (former tradename Solutol®HS15, currently designated Kolliphor° HS15) was acquired from BASF, Germany. Dulbecco’s Modified Eagles Medium (DMEM) was purchased from Thermo Fisher Scientific, Spain. All other chemicals used were of reagent grade.

Cadete A., Olivera A., Besev M., Dhal P.K., Gonçalves L., Almeida A.J., Bastiat G., Benoit J.P., de la Fuente M., Garcia-Fuentes M., Alonso M.J, & Torres D. (2019). Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs. Scientific Reports, 9, 11565.

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Synthesis of Thiol and Acrylate Functionalized Hyaluronic Acid

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Thiol and acrylate functionalized HA, as HA-SH and HA-AES, respectively, were prepared according to our previously reported procedures.^{32 (link)–33 (link)} In brief, sodium hyaluronate (430 kDa, Sanofi-Genzyme Corporation, Cambridge, MA) was dissolved in deionized water and reacted with 3,3’dithiobispropanoic dihydrazide in the presence of N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride at pH 4.75. The reaction mixture was treated with 1,4-dithiothreitol, purified by dialysis, and lyophilized to yield HA-SH with 60% thiol incorporation as confirmed by ¹H-NMR. Separately, sodium hyaluronate (5 kDa, Lifecore Biomedical, Chaska, MN) was converted to the tetrabutyl ammonium salt and dissolved in dimethyl sulfoxide before the addition of mono-2-(acryloyloxy)ethyl succinate (AES). The reaction was allowed to proceed at 50 °C for 24 h. The conjugate was precipitated in ether, purified with ion exchange resin, and dialyzed before lyophilization. ¹H-NMR analysis confirmed an acrylate degree of incorporation of 50%.

Fowler E.W., Ravikrishnan A., Witt R.L., Pradhan-Bhatt S, & Jia X. (2021). RGDSP-Decorated Hyaluronate Hydrogels Facilitate Rapid 3D Expansion of Amylase Expressing Salivary Gland Progenitor Cells. ACS biomaterials science & engineering, 7(12), 5749-5761.

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