Polyethylene glycol peg 6000

Sodium chloride, potassium chloride, disodium hydrogen phosphate, and potassium dihydrogen phosphate as components of phosphate buffered saline (PBS) pH 7.4 were purchased from AppliChem (Darmstadt, Germany). A PAA gel developed by Loch et al. [16 (link)] simulating the vitreous body was prepared according to the composition given in Table 1. Rotiphoresis gel 30 (37.5:1), ammonium peroxodisulfate, and tetramethylethylenediamine were purchased from Carl Roth (Karlsruhe, Germany). Agarose for the PAA gel-sheath was purchased from Sigma Aldrich, Germany. Model implants were prepared via hot-melt extrusion of FS (Sigma Aldrich, St. Louis, MO, USA) or TA (Caelo, Hilden, Germany) as active pharmaceutical ingredients, hydroxypropyl methylcellulose (HPMC; Affinisol 100LV/Affinisol 15LV; Dow Chemicals, Midland, TX, USA) and polyethylene glycol (PEG) 6000 (Carl Roth). All chemicals and solvents for the high-performance liquid chromatography (HPLC) were of analytical quality. A standard Formlabs Clear Resin (Formlabs, Somerville, MA, USA) was used for the 3D-printed EFC.

GO, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), N, N′-Dicyclohexylcarbodiimide (DCC), Chloroauric acid (HAuCl₄), and Folic acid (FA), 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and fetal bovine serum (FBS) were purchased from Sigma Aldrich, USA. Polyethylene glycol (PEG₆₀₀₀) was purchased from ROTH, Germany. 4- Dimethylaminopyridine (DMAP), Dimethyl sulfoxide (DMSO), sodium citrate, FeCl₃·6H2O and FeCl₂·6H2O received from Merck, Germany. Dulbecco’s Modified Eagle Medium (DMEM), Penicillin/Streptomycin (Pen/Strep), Trypsin–EDTA enzyme were provided by Gibco, USA.