Il 17rc mice

Manufactured by Genentech

The IL-17RC-/- mice are genetically modified mice that lack the interleukin-17 receptor C (IL-17RC) gene. These mice are a useful tool for studying the role of IL-17 signaling in various biological processes and disease models.

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Lab products found in correlation

Interleukin 6 (il 6), by Jackson ImmunoResearch (1 mentions) C57bl 6j, by Jackson ImmunoResearch (1 mentions) Rag2 il2rg, by Jackson ImmunoResearch (1 mentions) Balb c, by Jackson ImmunoResearch (1 mentions) C57bl 6, by Jackson ImmunoResearch (1 mentions)

2 protocols using il 17rc mice

Genetically Engineered Mouse Models for Neuroinflammation

Cited 2 times

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Inbred female C57BL/6J, Rag1^-/-, Rag2^-/-, IL-6^-/- and IL-10^-/- mice were obtained from the Jackson Laboratory (Bar Harbor, ME). IL-17A^-/-, CD11cdnTGF-RII, and CD4dnTGF-RII mice were described previously (38 (link)–40 (link)). IL-17RC^-/- mice were developed by Genentech and were obtained from the Mutant Mouse Regional Resource Center (University of California, Davis). IL-17RA^-/- and IL-17RA^-/-RC^-/- were developed in our Lab and described previously (41 (link)). IL-17RD^-/- mice were obtained from the Mutant Mouse Regional Resource Center (University of California, Davis). All mice used in this study have a B6 background and were bred in-house. Only female (6 to 8-wk-old) mice were used in the study as male mice are more resistance to HSV-IL-2-induced CNS demyelination than female mice (21 (link)). This is comparable to observations made in other models for MS.

Hirose S., Wang S., Jaggi U., Matundan H.H., Kato M., Song X.Y., Molesworth-Kenyon S.J., Lausch R.N, & Ghiasi H. (2023). IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination. Frontiers in Immunology, 14, 1102486.

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Murine Model for Pneumocystis Infection

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All mouse colonies were maintained in the Rangos Research Building Animal Facility and use was approved and performed in accordance with the University of Pittsburgh Institutional Care and Use Committee (Protocol: 14084329 and 16027674). C57BL/6, BALB/c, Cxcr5⁻^/⁻, Lta⁻^/⁻, Stat6⁻^/⁻, Gata1^tm6Sho/J, Rag1⁻^/⁻ and Rag2^−/−Il2rg^−/− mice were all ordered from The Jackson Laboratory. The Il17ra⁻^/⁻ and Il17rb⁻^/⁻ mice were generated at Amgen. The Il17rc⁻^/⁻ mice were generated at GenenTech. Both male and female mice were used throughout experiments in an equal manner. Mice ranged from 6–8 weeks old, unless otherwise specified. Mice were randomized based on cage. Sample size was determined using power calculations based off of prior experiments at day 14 post-infection that showed a 6-fold reduction in Pneumocystis burden with a 10% standard deviation. With a type I error rate of 0.05 and a power of 0.90, we calculated the use of at least 4 mice per group.

Eddens T., Elsegeiny W., de la Luz Garcia-Hernadez M., Castillo P., Trevejo-Nunez G., Serody K., Campfield B.T., Khader S.A., Chen K., Rangel-Moreno J, & Kolls J.K. (2017). Pneumocystis driven inducible bronchus associated lymphoid tissue formation requires Th2 and Th17 immunity. Cell reports, 18(13), 3078-3090.

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