The levels of free triiodothyronine (FT3) (reference range, 3.1–6.8 pmol/L), free thyroxine (FT4) (reference range, 12.0–22.0 pmol/L), thyroid stimulating hormone (TSH) (reference range, 0.270–4.20 mIU/L), thyroglobulin antibody (TGAb) (cut-off level, 115 IU/mL), thyroid peroxidase antibody (TPOAb) (cut-off level, 34 IU/mL), and TSH receptor antibody (TRAb) (cut-off level, 1.75 IU/L) were measured automatically by Cobas c8000 machine via utilizing a commercial electro-chemiluminescence immunoassay kit (Roche Diagnostics, Cobas 8000 analyzer e602 module). The intra-assay CVs of FT3, FT4, TSH, TGAb, TPOAb, and TRAb were 1.4–6.5%, 2.6–4.3%, 1.1–3.0%, 1.3–4.9%, 2.7–6.3%, and 0.9–7.6%, respectively, and the inter-assay CVs of coefficients of these indexes were 1.9–7.2%, 5.1–8.4%, 3.3–7.2%, 3.4–6.3%, 4.2–9.5%, and 1.9–11.4%, respectively.
Cobas 8000 analyzer e602 module
Manufactured by Roche
Sourced in Germany
The Cobas 8000 analyzer e602 module is a laboratory equipment designed for clinical chemistry testing. It is capable of performing various types of immunoassay analyses. The e602 module is part of the Cobas 8000 series of analyzers, which are intended for in-vitro diagnostic use in clinical laboratories.
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Lab products found in correlation
3 protocols using cobas 8000 analyzer e602 module
1
Thyroid Hormone Profile Measurement
2
Thyroid Function Biomarker Measurement
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Thyroxine and TSH concentrations were measured using electrochemiluminescence immunoassay (ECLIA) kit provided by Roche Diagnostics (Cobas 8000 Analyzer e602 module, Germany) following the manufacturer's instructions. Anti-TPO and anti-Tg antibodies were also determined using an ECLIA kit provided by Roche Diagnostics, cutoff values for abnormal levels were set at 34 IU/mL and 115 IU/ mL respectively.
3
Thyroid Hormone and Antibody Measurement
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The levels of free thyroxine (FT4) (reference range, 12-22 pmol/L), TSH (reference range, 0.27-4.2 mIU/L), TpoAb (cut-off level, 34 IU/mL), and TgAb (cut-off level, 115 IU/mL) were determined in all the subjects on the same day of sampling, utilizing a commercial electrochemiluminescence immunoassay kit (Roche Diagnostics, Cobas 8000 analyzer e602 module, Germany). The intra-assay CVs of TSH, FT4, TpoAb, and TgAb were 1.73% to 2.44%, 1.73% to 2.51%, 4.07% to 7.13%, and 4.20% to 6.60%, respectively. The inter-assay CVs of TSH, FT4, TpoAb, and TgAb were 2.05% to 4.12%, 2.11% to 2.57%, 5.04% to 8.49%, and 5.33% to 7.22%, respectively.
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