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80 protocols using version 17

1

Quantitative and Qualitative Assessments

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All values are expressed as the mean ± SD. Differences with a P < 0.05 were considered statistically significant. The Wilcoxon signed-rank test was used for quantitative values. Friedman’s test was used for multiple comparisons of qualitative values. If a significant difference was found, pairwise comparisons were performed with the Scheffe’s test. The degree of inter-observer agreement for each qualitative assessment was determined by calculating Cohen’s κ coefficient; the scale for κ coefficients for inter-observer agreement was as follows: <0.20 = poor, 0.21–0.40 = fair, 0.41–0.60 = moderate, 0.61–0.80 = substantial, and 0.81–1.00 = near perfect. MedCalc version 17.9.2 (MedCalc Software, Ostend, Belgium) and BellCurve for Excel version 2.15 were used for the statistical analyses.
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2

Stent Expansion Predictors Analysis

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Continuous data are presented as mean ± standard deviation or median with IQR [Q1–Q3]. Categorical data are expressed as count and percentage. Normal distribution was verified by the Kolmogorov–Smirnov test. Continuous data were compared by the Student t test or by Mann–Whitney U test, depending on the data distribution. Categorical data were analyzed with the χ2 or Fisher exact test. A p value < 0.05 was considered statistically significant. Multivariable backward stepwise logistic regression (Wald) was used to determine the odds ratio of achieved primary efficacy endpoints: relative stent expansion >80%. Model included all predictors with a p value of less than 0.1 and without a significant multicollinearity effect. The data are presented as odds ratios (OR) with 95% confidence intervals (95% CI). The statistical analysis was performed using MedCalc version 17.9.2 (MedCalc Software, Ostend, Belgium).
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3

Disinfection Efficacy Analysis Protocol

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Data were analyzed by performing a Wilcoxon rank sum test, using a software program called MedCalc, Version 17 (MedCalc Software, Ostend, Belgium), to compare the difference between the data pre- and post-disinfection. Statistical significance was set at P < .05.
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4

Gender Salary Gap Analysis

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Data were analyzed using SPSS version 25 (IBM Corp., Armonk, NY, USA) and MedCalc version 17 (MedCalc Software, Mariakerke, Belgium). Categorical variables were presented as frequency and percentage, whereas continuous variables were presented as mean±standard deviation (SD), or as median and interquartile range (IQR; 25th-75th percentile). Chi-squared or Fisher’s exact tests were used to compare the categorical variables. The normality of the variables was determined using the Shapiro–Wilk test. Normally distributed data were expressed with mean and SD, and median and IQRs were used for non-normally distributed data. A t-test or one-way analysis of variance and Mann–Whitney U-test were used to compare continuous variables. Using two-way analysis of variance, we assessed salary gaps among the positional ranks for differences in the importance attributed to gender factors. All tests were two-tailed, and a p-value of <0.05 was considered statistically significant.
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5

Statistical Analysis of Clinical Outcomes

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Statistical analysis was performed using IBM SPSS Statistics 22.0 version 25 (IBM Corp., Armonk, NY, USA). Categorical variables are presented as frequencies and percentages, whereas continuous variables are reported as the means ± standard deviations (SDs) or as the medians and interquartile ranges (IQRs, 25th-75th percentile). The normality of the distribution of the variables was determined using the Kolmogorov-Smirnov (K-S) test. Normally distributed data were expressed as the means and SDs, while the medians and IQRs were used for nonnormally distributed data. Groups were compared with student’s t-test or Mann–Whitney U-test as appropriate. Correlation analysis was performed by the Pearson method or Spearman method. The chi-square or Fisher’s exact test was used to compare categorical variables. The odds ratios and their 95% confidence intervals (ORs, 95% CIs) were calculated to show the associations between each predictor and the risks for clinical outcomes. The receiver operating characteristic curve (ROC) and the area under the curve (AUC) were calculated by MedCalc version 17 (MedCalc Software, Mariakerke, Belgium). The cut-off point of the ROC was also calculated to obtain the sensitivity and specificity of the model. All tests were two-tailed, P < 0.05 was considered statistically significant, and P < 0.01 was considered extremely significant.
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6

COVID-19 Impact on Adult OHCA Survival

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Data were analyzed by using IBM SPSS Statistics version 25 (IBM Corp., Armonk, NY, USA) and MedCalc version 17 (MedCalc Software, Mariakerke, Belgium). The chi-square or Fisher’s exact tests were used to compare categorical variables. The normality of the variables was determined by using the Shapiro–Wilk test. A t-test or one-way analysis of variance and the Mann–Whitney U test were used to compare continuous variables. The associations between the study phase and outcomes were assessed using multivariable logistic regression analysis. We analyzed the data to identify the changes in the CPR characteristics and survival outcomes of adult OHCA patients following the COVID-19 outbreak. The adjusted odds ratios (ORs) were calculated after adjustment for sex, age, comorbidities, location of event, witness status, bystander CPR, and shockable rhythm. The characteristics of the adjusted ORs were described by using forest plots, and the OR with 95% confidence intervals (CI) were estimated. All tests were two-tailed, and a p-value of <0.05 was considered statistically significant.
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7

Disinfection Efficacy Statistical Analysis

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Data were pooled from the studies and analyzed by performing a Mann-Whitney rank sum test, using MedCalc (version 17) statistical analysis software (MedCalc Software, Ostend, Belgium), to compare the difference between the data before and after disinfection. Threshold statistical significance was set at p<0.05.
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8

Everolimus Treatment Response Analysis

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The analysis set included patients with documented administration or prescription of everolimus with at least 1 follow-up during treatment. All variables investigated in this non-interventional study were analysed using descriptive statistical methods. The statistical analysis was conducted using MedCalc Version 17 and Excel 2010. Survival time was analysed using the Kaplan-Meier method.
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9

Statistical Analysis of Biomedical Data

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IBM SPSS Statistics version 25 (IBM Corp., Armonk, NY, USA) and MedCalc version 17 (MedCalc Software, Mariakerke, Belgium) were used for data analysis. Categorical variables are presented as frequency and percentage, whereas continuous variables are presented as the median and interquartile range (25th to 75th percentile). The chi-square or Fisher's exact test was used to compare categorical variables. The Shapiro–Wilk test was used to determine the normality of the variables. A t-test or one-way analysis of variance and the Mann–Whitney U test were used to compare continuous variables. All tests were 2 tailed, and P <0.05 was considered statistically significant.
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10

Sleepiness and Depression in EM Residents

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We analyzed the data using IBM SPSS Statistics software, version 25 (IBM Corp., Armonk, NY, USA) and MedCalc version 17 (MedCalc Software, Mariakerke, Belgium). Categorical variables were presented as frequencies and percentages, whereas continuous variables were reported as means ± standard deviations (SD), or as medians and interquartile ranges (IQRs, 25th–75th percentile). We used the Chi-squared or Fisher’s exact test to compare categorical variables. The normality of the distribution of the variables was determined using the Shapiro–Wilk test. Normally distributed data were expressed as means and standard deviations, while medians and IQRs were used for non-normally distributed data. A t-test or one-way analysis of variance and the Mann–Whitney U-test were used to compare continuous variables. Using two-way analysis of variance, we assessed the sleepiness and depression score gaps among EM residents across varying residency years, and according to their gender. Univariate and multivariate regression analyses were used to identify risk factors for sleepiness or depression rates among the study participants. The odds ratio (OR) and 95% CI were estimated. All tests were two-tailed, and a p-value of <.05 was considered to indicate statistical significance.
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