Phenylephrine phe

Manufactured by Pfizer

Sourced in United States

Phenylephrine (PHE) is a synthetic sympathomimetic amine that is used as a decongestant and pupillary dilator. It acts as an alpha-adrenergic agonist, causing vasoconstriction and reducing edema in the mucous membranes.

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Lab products found in correlation

Sodium bicarbonate nahco3, by Vetec (3 mentions) Nω nitro l arginine methyl ester l name, by Merck Group (3 mentions) Indomethacin, by Merck Group (3 mentions) R apomorphine, by Merck Group (3 mentions) Acetylcholine chloride ach, by Merck Group (2 mentions) Sodium chloride (nacl), by Dinâmica (2 mentions) Calcium chloride dihydrate, by Vetec (2 mentions) Tempol, by Merck Group (2 mentions) Glucose c6h12o6, by Dinâmica (2 mentions) Formaldehyde, by Vetec (2 mentions) Cremophor, by Merck Group (1 mentions) Apocynin, by Merck Group (1 mentions) Sodium bicarbonate, by Dinâmica (1 mentions) 1 1 diphenyl 2 picrylhydrazyl dpph, by Merck Group (1 mentions) Ethylenediaminetetraacetic acid edta, by Merck Group (1 mentions) Glucose c6h12o6, by Vetec (1 mentions) Apocinin, by Merck Group (1 mentions) Sodium bicarbonate nahco3, by Dinâmica (1 mentions) Aminophylline, by Merck Group (1 mentions) Acetylcholine ach, by Merck Group (1 mentions)

Spelling variants of this product

Phenylephrine (2 citations)

6 protocols using phenylephrine phe

Isolated Vascular Tissue Preparation

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Calcium chloride dihydrate (CaCl₂·2H₂O), potassium chloride (KCl), and sodium bicarbonate (NaHCO₃) were purchased from Vetec (Rio de Janeiro, RJ, Brazil). Glucose (C₆H₁₂O₆), magnesium sulfate heptahydrate (MgSO₄·7H₂O), hydrochloric acid (HCl), and monobasic potassium phosphate (KH₂PO₄) were from Nuclear (Porto Alegre, RS, Brazil). Sodium chloride (NaCl) was purchased from Dinâmica (Diadema, SP, Brazil) and acetylcholine chloride (ACh) from Merck (Brazil). Phenylephrine (PHE) was obtained from Pfizer (USA), and Nω-nitro-L-arginine methyl ester (L-NAME) was purchased from Sigma-Aldrich (Brazil). Ethylenediamine tetraacetic acid (EDTA) (1 : 250) came from BioTécnica-Advanced Biotechnology (Brazil), and carbogen mixture (95% O₂ and 5% CO₂) was obtained from White Martins (Brazil). All substances were weighed on an analytical balance, GEHAKA model AG 200 (Sao Paulo, SP, Brazil).

de Freitas Brito A., Silva A.S., de Souza A.A., Ferreira P.B., de Souza I.L., da Cunha Araujo L.C., da Silva Félix G., de Souza Sampaio R., da Conceição Correia Silva M., Tavares R.L., de Andrade Pereira R., Neto M.M, & Silva B.A. (2019). Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity. Oxidative Medicine and Cellular Longevity, 2019, 7838149.

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Vasoactive Compound Preparation Protocol

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Magnesium sulfate (MgSO₄), potassium chloride (KCl), calcium chloride (CaCl₂), sodium chloride (NaCl) and formaldehyde were purchased from Vetec Química Fina Ltda. (Brazil). Glucose (C₆H₁₂O₆) and sodium bicarbonate (NaHCO₃) were purchased from Dinâmica (Brazil). Potassium monobasic phosphate (KH₂PO₄), sodium hydroxide (NaOH) and hydrochloric acid (HCl) were purchased from Nuclear (Brazil). These substances, except glucose, NaCl and NaHCO₃ were diluted in distilled water to obtain each solution, which were maintained under refrigeration.
Phenylephrine (Phe) was purchased from Pfizer (USA). Acetylcholine (ACh), sodium nitroprusside (SNP), L-N^ω-nitroarginine methyl ester (L-NAME), indomethacin, tempol, apocynin, Cremophor® and R-(-)-apomorphine were obtained from Sigma-Aldrich (Brazil). All substances were diluted in distilled water as needed for each experimental protocol. The carbogen mixture (95% O₂ and 5% CO₂) was acquired from White Martins (Brazil).

de Souza I.L., Barros B.C., de Oliveira G.A., Queiroga F.R., Toscano L.T., Silva A.S., Silva P.M., Interaminense L.F., Cavalcante F.D, & da Silva B.A. (2017). Hypercaloric Diet Establishes Erectile Dysfunction in Rat: Mechanisms Underlying the Endothelial Damage. Frontiers in Physiology, 8, 760.

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Vascular Reactivity Assay Reagents

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Calcium chloride dihydrate (CaCl₂·2H₂O), magnesium sulfate heptahydrate (MgSO₄·7H₂O), and glucose (C₆H₁₂O₆) were purchased from Vetec (Rio de Janeiro, RJ, Brazil). Sodium bicarbonate (NaHCO₃), sodium chloride (NaCl), and potassium chloride (KCl) were purchased from Nuclear (Porto Alegre, RS, Brazil). Monobasic potassium phosphate (KH₂PO₄), monobasic sodium phosphate (NaH₂PO₄), sodium hydroxide (NaOH), and hydrochloric acid (HCl) were purchased from Dinâmica (Diadema, SP, Brazil).
Phenylephrine (PHE) was purchased from Pfizer (USA). ACh, R-(-)-apomorphine, Nω-nitro-L-arginine methyl ester (L-NAME), indomethacin, tempol, apocinin, ethylenediamine tetraacetic acid (EDTA), MDA, and 1,1-diPHEnyl-2-picrylhydrazyl (DPPH) were purchased from Sigma-Aldrich (Brazil). To obtain the stock solutions, substances used in the functional experiments were dissolved and diluted in distilled water (indomethacin and apocinin were dissolved in absolute alcohol 96° GL), being, respectively, kept at 4 or -20°C. The carbogen mixture (95% O₂ and 5% CO₂) was obtained from White Martins (Brazil). All substances were weighed on an analytical balance, GEHAKA model AG 200 (Sao Paulo, SP, Brazil).

Diniz A.F., de Souza I.L., dos Santos Ferreira E., de Lima Carvalho M.T., Barros B.C., Ferreira P.B., da Conceição Correia Silva M., Júnior F.F., de Lima Tavares Toscano L., Silva A.S., de Andrade Cavalcante F, & da Silva B.A. (2020). Potential Therapeutic Role of Dietary Supplementation with Spirulina platensis on the Erectile Function of Obese Rats Fed a Hypercaloric Diet. Oxidative Medicine and Cellular Longevity, 2020, 3293065.

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Evaluation of Pharmacological Agents

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The R-(-)-apomorphine, malondialdehyde (MDA), 1,1-diphenyl-2-picryl hydrazyl (DPPH) and acetylcholine (ACh) were obtained from Sigma-Aldrich (São Paulo, Brazil). Phenylephrine (Phe) was purchased from Pfizer (Kalamazoo, USA). Magnesium sulphate (MgSO₄), potassium chloride (KCl), calcium chloride (CaCl₂), sodium chloride (NaCl) and formaldehyde were purchased from Vetec Química Fina Ltda. (São Paulo, Brazil). Glucose (C₆H₁₂O₆) and sodium bicarbonate (NaHCO₃) were purchased from Dinâmica (São Paulo, Brazil). Potassium monobasic phosphate (KH₂PO₄), sodium hydroxide (NaOH) and hydrochloric acid (HCl) were purchased from Nuclear (São Paulo, Brazil). These substances, except the glucose, NaCl and NaHCO₃ were diluted in distilled water to obtain each solution, which were maintained under refrigeration.

de Souza I.L., Barros B.C., Ferreira E.D., Queiroga F.R., Vasconcelos L.H., Toscano L.D., Silva A.S., da Silva P.M., Cavalcante F.D, & da Silva B.A. (2022). Supplementation with Spirulina platensis Prevents Damage to Rat Erections in a Model of Erectile Dysfunction Promoted by Hypercaloric Diet-Induced Obesity. Marine Drugs, 20(8), 467.

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Balanced Salt Solution Preparation

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Glucose (C₆H₁₂O₆), monobasic potassium phosphate (KH₂PO₄), hydrochloric acid (HCl), and magnesium sulfate heptahydrate (MgSO₄.7H₂O) were obtained from Nuclear (Brazil). Sodium chloride (NaCl) was purchased from Dinâmica (Brazil). Potassium chloride (KCl), calcium chloride dihydrate (CaCl₂.2H₂O), and sodium bicarbonate (NaHCO3) were acquired from Vetec (Brazil) and acetylcholine chloride (ACh) from Merck (Brazil). Phenylephrine (PHE) was obtained from Pfizer (United States) and aminophylline and indomethacin from Sigma Aldrich (Brazil). Ethylenediaminetetraacetic acid (EDTA) (1:250) was purchased from BioTécnica-Advanced Biotechnology (Brazil) and carbogen mixture (95% O₂ and 5% CO₂) from White Martins (Brazil). The weighing of the substances was done with a GEHAKA analytical balance model AG 200 (Brazil).

Brito A.D., Silva A.S., de Souza A.A., Ferreira P.B., de Souza I.L., Araujo L.C, & da Silva B.A. (2022). Supplementation With Spirulina platensis Improves Tracheal Reactivity in Wistar Rats by Modulating Inflammation and Oxidative Stress. Frontiers in Pharmacology, 13, 826649.

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Preparation of Pharmacological Solutions

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Calcium chloride dihydrate (CaCl₂.2H₂O), potassium chloride (KCl) and sodium bicarbonate (NaHCO₃) were purchased from Vetec (Rio de Janeiro - RJ, Brazil). Glucose (C₆H₁₂O₆), magnesium sulfate heptahydrate, (MgSO₄.7H₂O), hydrochloric acid (HCl) and monobasic potassium phosphate (KH₂PO₄) were obtained from Nuclear (Porto Alegre - RS, Brazil). Sodium chloride (NaCl) was purchased from Dynamics (Diadema-SP, Brazil). The acetylcholine (ACh) was obtained from Merck (Brazil). Phenylephrine (PHE) was acquired from Pfizer (USA). Nω-nitro-L-arginine methyl ester (L-NAME) was purchased from Sigma-Aldrich (Brazil). The ethylenediaminetetraacetic acid (EDTA) (1:250) was purchased from BioTécnica-Advanced Biotechnology (Brazil). The carbogen mixture (95% O₂ and 5% CO₂) was obtained from White Martins (Brazil). All substances were weighed on an analytical balance, model AG 200 GEHAKA (São Paulo-SP, Brazil).

Brito A.D., Silva A.S., de Souza A.A., Ferreira P.B., de Souza I.L., Araujo L.C., Félix G.D., Sampaio R.D., Silva M.D., Tavares R.L., Pereira R.D., Miranda Neto M, & da Silva B.A. (2018). Aortic Response to Strength Training and Spirulina platensis Dependent on Nitric Oxide and Antioxidants. Frontiers in Physiology, 9, 1522.

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