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Biograph mct 64 scanner

Manufactured by Siemens
Sourced in Germany

The Biograph mCT-64 scanner is a medical imaging device produced by Siemens. It is a positron emission tomography (PET) and computed tomography (CT) combined system that can acquire both PET and CT images simultaneously. The device features a 64-slice CT scanner and is designed for clinical applications in nuclear medicine and radiology.

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8 protocols using biograph mct 64 scanner

1

Multimodal Imaging for Neuroendocrine Tumors

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CT and MRI scans of the neck, chest, abdomen, and pelvis were performed as previously described [13 (link)]. All 22 patients underwent 68Ga-DOTATATE and 18F-FDG PET/CT, and CT/MRI. In addition, 12 patients also underwent 18F-FDOPA PET/CT and 11 underwent 18F-FDA PET/CT. All imaging studies were performed within a median of 8.5 days.
PET/CT scans from the upper thighs to the skull were performed 60 min, 60 min, 30 min, and approximately 8 min after intravenous injection of 68Ga-DOTATATE, 18F-FDG, 18F-FDOPA, and 18F-FDA at mean administered activities of 191.4±8.3 MBq, 316.5±59.4 MBq, 466.3±13.0 MBq, and 39.3 ± 0.7 MBq, respectively. Carbidopa (200 mg) was administered orally 60 min before each 18F-FDOPA scan [23 (link)]. All PET/CT scans were performed on a Siemens Biograph-mCT 64 scanner and a Biograph-mCT 128 PET/CT scanner (Siemens Medical Solutions). PET images were reconstructed using an iterative algorithm provided by the manufacturer, also utilizing point spread function and time of flight. Low-dose CT scans for attenuation correction and anatomical coregistration were performed without administration of contrast agent and were used for anatomical localization.
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2

18F-FAPI PET/CT Imaging Protocol

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The patients were not specially prepped on the day of 18 F-FAPI PET/CT scanning. A Biograph mCT-64 scanner (Siemens, Germany) was used. The scanning was performed about 60 min after intravenous injection of 18 F-FAPI (0.12 millicurie/kg). The localizer was positioned with a scout head view. Low-dose CT (120 kV/110 mA) was then performed for anatomical localization and attenuation correction. Single-bed emission scans were obtained in 3-dimensional mode (acquisition time, 3 min). Reconstruction of data was done using an ordered subset expectation maximization iterative reconstruction algorithm (three iterations, 21 subsets). The emission data were corrected for random, scatter, and decay.
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3

PET/CT Imaging of Metastatic Disease

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18F-FDG was administered at a dose of 5.18 MBq/kg after at least 4–6 h of fasting. PET/CT scans from the skull to the proximal thigh were acquired about 60 min after injection using a Biograph mCT-64 scanner (Siemens). When metastasis was suspected to involve the extremities, imaging from the vertex to the toes including the arms was performed. Chloral hydrate sedation (50 mg/kg) was used 30 min before scanning for children unable to follow instructions. PET images were reconstructed using 3D ordered subset expectation maximization (3 iterations, 24 subsets). CT scans were acquired with 100-kV tube voltage, automated tube current modulation, 3-mm slice thickness, and a pitch of 1.5.
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4

18F-FDG PET/CT Protocol for Thyroid Cancer

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18F-FDG PET/CT examinations were performed using a Biograph mCT-64 scanner (Siemens/CTI, Knoxville, TN) in a state of thyroid hormone withdrawal (above 30 mIU/L) before RAI treatment. Before the examination, patients fasted for at least six hours to ensure a serum glucose concentration of less than 150 mg/dL. Patients were injected intravenously with 5.55 MBq/kg of 18F-FDG, and no intravenous or oral contrast agents were administered. Sixty minutes later, patients were scanned with a whole-body, three-dimensional PET/CT scan from the base of the skull to the mid-thigh. The acquisition consisted of a CT scan (120 kV; 300 mAs; slice thickness, 3 mm; pitch, 1.5) for the purpose of attenuation correction for anatomical co-registration of PET data, followed by three-dimensional emission imaging for two minutes per bed position. The standard uptake value (SUV) of BMs was obtained.
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5

Standardized Brain 18F-FDG PET/CT Imaging

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Brain 18F-FDG PET/CT imaging was performed according to the routine institutional procedures. In brief, all patients fasted from food and sugary drinks for at least 4 h prior to intravenous injection of approximately 25–185 MBq 18F-FDG based on 3.7 MBq/kg body weight. All patients rested in a quiet and dim room before and after injection. About 50 min following injection, a brain PET/CT scanning was performed for 10 min on a Biograph mCT-64 scanner (Siemens, Erlangen, Germany).
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6

18F-PSMA-1007 PET/CT Imaging Protocol

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The patients were not specially prepped on the day of 18F-PSMA-1007 PET/CT scanning. A Biograph mCT-64 scanner (Siemens, Germany) was used. The scanning was performed about 180 min (14 (link)) after intravenous injection of 18F-PSMA-1007. The localizer was positioned with a scout head view. Low-dose CT (120 kV/110 mA) was then performed for anatomical localization and attenuation correction. Single-bed emission scans were obtained in three-dimensional mode (acquisition time, 3 min). Reconstruction of data was done using an ordered subset expectation maximization iterative reconstruction algorithm (three iterations, 21 subsets). The emission data were corrected for random, scatter, and decay.
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7

18F-FDG PET/CT Imaging Protocol

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According to the guidelines of the European Association of nuclear medicine (EANM), all patients underwent whole-body 18F-FDG positron emission tomography on Siemens Biograph-64 mCT scanner. All patients fasted for at least 6 h before acquisition, and the blood glucose levels were controlled below 150mg/dL. FDG-PET/CT was performed 60 min (60 ± 3 min) after injection of 3.7–5.55 MBq 18F-FDG per kg of body weight. PET image reconstruction with a 3-dimensional (3D) ordered-subset expectation maximization (OSEM) algorithm: 3 iterations, 24 subsets; 2.75 mm × 3.12 mm× 3.12 mm voxel size. The field of view (FOV) was 700 mm. Before PET scanning, CT was performed with attenuation correction methods to obtain image with matrix size of 512 × 512 (80 Ma, 120 kV). PET and CT results were reviewed on the workstation to display the fused image frame by frame. Then, the positron emission tomography image (voxel size 3.12 mm, slice thickness 2.75 mm) was interpolated to the same resolution as the computed tomography image (voxel size 0.98 mm, slice thickness 2 mm) (Supplementary Materials Table S1).
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8

Whole-Body 18F-FDG PET/CT Imaging Protocol

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All patients underwent a whole-body 18 F-FDG PET/CT using a Biograph 64 mCT scanner (Siemens). Patients fasted for at least 8 h to ensure a serum glucose level less than 10 mmol/L. The time difference between injection and acquisition was 71 6 9 min (range, 52-88 min) after injection of 229.4 6 22.2 MBq (6.2 6 0.6 mCi; range, 181.3-270.1 MBq [4.9-7.3 mCi]) of 18 F-FDG. PET raw data were acquired for 1 min per bed position with the exception of the bed position covering the liver, which was acquired for 3 min. CT was performed with a tube voltage of 120 kV and a tube current of 50 mAs.
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