Hydroxypropyl methylcellulose hpmc

LCS (Batch No. GC20140503) with a viscosity of 11 mPa (1% w/v in water), average molecular weight of 13 kDa, degree of deacetylation >90% and particle size of ~100 µm (95% of the sample <100 µm). High molecular weight chitosan with an average molecular weight of 150 kDa, average particle size of 180–100 μm, viscosity of 150 mPas (1% w/v in water), and degree of deacetylation of >90% (batch No. GC20140510) and d-glucosamine HCl were all obtained from G.T.C. Union Group LTD., Qingdao, China. XG was purchased from Jungbunzlauer Ladenburg GmbH, Ladenburg, Germany (Batch No. 2504519) having a viscosity range of 1400–1600 mPa (1% w/v in water), average molecular weight of 1200 kDa and average particle size less than 180 μm.
Dyphylline, 7-(2,3-dihydroxy-propyl theophylline), 99%, was obtained from ACROS Organics, Geel, Belgium. USP grade metoprolol succinate (MS) was obtained from Ipca Laboratories Ltd., Mumbai, India (batch No. A0337986). Hydroxypropyl methylcellulose (HPMC) was purchased from Dow Chemical Co., Plaquemine, LA, USA. Sodium alginate and guar gum were obtained from Central Drug House, New Delhi, India; α-lactose monohydrate (Pharmatose 200 M) was supplied by DFE Pharma, Veghel, the Netherlands. All other reagents used were of analytical grade and were accessed from the Jordanian Pharmaceutical Manufacturing Co., (JPM), Naor, Jordan.

Ferrous fumarate (food grade) was obtained from Dr. Paul Lohmann Chemicals (Emmerthal, Germany); soy stearin (SS) was obtained from JVS Food Pvt, (India); hydroxypropyl methylcellulose (HPMC) was obtained from Dow Chemical Company (Midland, Michigan USA); titanium (IV) oxide was obtained from ACROS Organics (Fair Lawn, New Jersey, USA); folic acid was obtained from Bulk Pharmaceuticals Inc., (Toronto, Ontario, Canada); potassium iodate was obtained from Sigma–Aldrich Chem (Oakville, Ontario, Canada); absolute ethanol and dichloromethane were obtained from Thermo Fischer Scientific (Mississauga, Ontario, Canada); sodium carbonate, potassium iodide and starch indicator were obtained from Caledon Laboratory Ltd (Georgetown, Ontario, Canada); sulfuric acid was obtained from EMD Chemicals Inc. (Oakville, Ontario, Canada); and 1.0% sodium thiosulfate solution was obtained from VWR International, (Mississauga, Ontario, Canada); vegetable shortening, semolina, rice grains and ingredients used for cooking were obtained from Walmart (Toronto, Ontario, Canada).All chemicals used for the fortification of salt were food-grade, while those used for analysis were ACS grade.