Au640 analyzer

Manufactured by Olympus

Sourced in Japan

The AU640 analyzer is a clinical chemistry analyzer designed for routine diagnostic testing in medical laboratories. It provides automated analysis of various biochemical parameters in biological samples such as blood, urine, and other body fluids. The AU640 analyzer is capable of performing a wide range of assays, including enzymatic, immunochemical, and colorimetric tests, to support the diagnosis and monitoring of various medical conditions.

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Lab products found in correlation

Accu chek active meter, by Roche (1 mentions) Au 680 autoanalyser, by Olympus (1 mentions)

Close spelling variants of this product

AU640 Clinical Chemistry Analyzer AU640 automatic biochemical analyzer AU640 automatic blood biochemical analyzer AU640 automatic analyzer AU640 Chemistry Immuno-Analyzer AU640 auto analyzer AU640

6 protocols using au640 analyzer

Evaluating Glycemic Control and Metabolic Markers

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The control rate, which was defined as HbA1c level lower than 7%, and the change in HbA1c values were the primary endpoint [18 ]. HbA1c was measured using affinity HPLC method (Automatic HA-8160 Analyzer HA-8160, Arkray Factory, Inc., Shiga, Japan). Fingertip blood was collected and FPG was measured using a blood glucose analyzer (ACCU-CHEK Active Meter, Roche Diagnostics, Indianapolis, USA). The 2hPG level was measured after taking a standardized meal (Olympus AU640 Analyzer, Olympus Optical Co., Ltd., Shizuoka, Japan). β-cell function was evaluated from venous blood to determine plasma insulin and C-peptide level, using the homeostatic model assessment (HOMA) to quantify HOMA insulin resistance (HOMA-IR) and β-cell function (HOMA-β) [19 (link)].
Blood pressure (BP) was collected at each visit. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured by enzymatic methods (Olympus AU640 Analyzer, Olympus Optical Co., Ltd., Shizuoka, Japan).
All the changes in test results and symptoms of each outpatient should be recorded in detail, and we collected the records of the first visit and 6, 12, 18, 24, 36, 48, 60 months from the first visit.

Tian J., Lian F., Yu X., Cui Y., Zhao T., Cao Y, & Tong X. (2016). The Efficacy and Safety of Chinese Herbal Decoction in Type 2 Diabetes: A 5-Year Retrospective Study. Evidence-based Complementary and Alternative Medicine : eCAM, 2016, 5473015.

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Adolescent Biologic Sample Analysis

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Study participants were asked to voluntarily submit any of the following biologic samples at age 15.5 years; urine, hair, and/or bloodspots. Two hundred and forty two (242) subjects submitted at least one of the biologic measures. All biologic samples were analyzed by the United States Drug Testing Laboratory (USDTL) (DesPlaines, IL, USA).
Urine specimens were analyzed by USDTL for cannabinoids, coti-nine, and ethyl glucuronide (Etg) using Thermofisher Microgenics DRI immunoassay reagents on an Olympus AU640 analyzer. The total number of usable urine samples was n = 222.

Shulman L.M., Manor Y., Handsher R., Delpeyroux F., McDonough M.J., Halmut T., Silberstein I., Alfandari J., Quay J., Fisher T., Robinov J., Kew O.M., Crainic R, & Mendelson E. (2000). Molecular and Antigenic Characterization of a Highly Evolved Derivative of the Type 2 Oral Poliovaccine Strain Isolated from Sewage in Israel. Journal of Clinical Microbiology, 38(10), 3729-3734.

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Estimating Electrolyte Excretion from 24-Hour Urine

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A single timed 24-hour urine collection was obtained for estimation of electrolyte excretion. Participants were given written and verbal instructions for the 24-hour collection. The first urine of the day was discarded and all urine over the following 24 hours was collected in standard containers that were provided. Total volume of the collection was measured. Urine aliquots were stored at −20°C before being transported frozen to the certified laboratory (ADICON Clinical Laboratory Inc., Jinan, China). In accordance with the standard procedure, urinary sodium and potassium were measured using ion selecting electrode method by Olympus AU 680 autoanalyser (coefficient of variation was 1.5% for sodium and 2.5% for potassium). Creatinine was measured using the picric acid method by Olympus AU640 Analyzer (coefficient of variation was 3.0%).
The 24-hour urine collections were assessed for completeness using creatinine excretion in relation to weight (i.e. the creatinine coefficient = creatinine [mg/day]/body weight [kg]). Creatinine coefficients of 14.4 to 33.6 in men and 10.8 to 25.2 in women were classified as indicating an Acceptable 24-hour urine collection [18 (link)]. Daily salt intake was estimated based on calculation of 24-hour urinary sodium excretion on the assumption that all sodium ingested was in the form of sodium chloride.

Xu J., Wang M., Chen Y., Zhen B., Li J., Luan W., Ning F., Liu H., Ma J, & Ma G. (2014). Estimation of salt intake by 24-hour urinary sodium excretion: a cross-sectional study in Yantai, China. BMC Public Health, 14, 136.

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Cardiac Analyte Extraction and Measurement

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For cardiac analytes, heart tissue samples were pulverized in liquid nitrogen and saved in -80 ⁰C degree freezer until analysis. cAMP in tissue was extracted using 5% trichloroacetic acid and ether as described previously [29 (link)] and measured using a competitive enzyme immunoassay from Cayman Chemical (Cat#581001, Ann Arbor, MI).
Plasma and tissue glucose and lactate concentrations were analyzed using an Olympus AU640 analyzer (Olympus America Inc., Melville, NY) using reagents from Olympus. Cardiac glycogen was measured in concentration of glucosyl units as previously described [30 (link)]. Active GLP-1 in plasma was measured using a GLP-1 EIA kit (Linco Research Inc, Cat#EGLP-35K) in the presence of (Dipeptidyl Peptidase-4) DPP4 (EMD Millipore Corporation, Cat#DPP4) in either diluted or undiluted plasma samples from the in vivo studies.

Aravindhan K., Bao W., Harpel M.R., Willette R.N., Lepore J.J, & Jucker B.M. (2015). Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart. PLoS ONE, 10(6), e0130894.

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Urinary Creatinine and Albumin Excretion

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Urinary creatinine excretion was assessed using the picric acid method, and 24-h urinary albumin excretion (UAE) was assessed using an immunonephelometric method, both on an Olympus AU640 Analyzer. The albumin to creatinine ratio (ACR) was calculated, as were the agreements between albuminuria as determined by UAE and by ACR. For UAE, <30 mg/d, 30–299 mg/d and ≥300 mg/d were defined as normal, microalbuminuria and macroalbuminuria. The corresponding value for ACR was <30 mg/g, 30–299 mg/g and ≥300 mg/g, respectively.
Each 24-h urine sample was assessed for completeness using urinary volume and gender specific urinary creatinine cut-off point. Incompleteness was defined as 24-h urinary volume < 500 ml, and/or 24-h urinary creatinine < 1.91 or >18.27 mmol in men, or < 1.36 or >14.28 mmol in women, with these samples excluded from analysis.
Of the 2112 participants, 88 provided incomplete 24-h urine collection, and 44 failed to provide the blood sample. Thus, the study involved 1980 participants.

Yan L., Ma J., Guo X., Tang J., Zhang J., Lu Z., Wang H., Cai X, & Wang L. (2014). Urinary albumin excretion and prevalence of microalbuminuria in a general Chinese population: a cross-sectional study. BMC Nephrology, 15, 165.

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Lamb Blood Biochemical Profile Analysis

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Lamb blood samples were collected at the same time when they were weighted (1, 15, and 30 days) from the jugular vein (10 mL) into sterile vacuum tubes (Venoject^®, Sterile Terumo Europe, Leuven, Belgium). After taking the blood samples, serum was separated by centrifugation (10 min) at 1609.92× g and analyzed in an Olympus AU640 analyzer. In the blood serum, mineral concentrations (calcium—Ca; inorganic phosphorus—P; iron—Fe; magnesium—Mg), biochemical parameters (urea, glucose, total proteins, cholesterol, albumin, globulin, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), hydroxybutyrate (BHB), non-esterified fatty acids (NEFAs), glutathione peroxidase (GPX), and superoxide dismutase (SOD)), and hepatic enzyme activity (alanine aminotransferase—ALT; aspartate aminotransferase—AST; alkaline phosphatase—ALP; gamma-glutamyltransferase—GGT; creatine kinase—CK) were all determined using Olympus System Reagents (OSR), manufactured and distributed by Olympus Diagnostica GmbH (Irish branch), Lismeehan, Ireland. Content of globulin was determined as the difference between total protein and albumin.

Novoselec J., Šalavardić Ž.K., Samac D., Ronta M., Steiner Z., Sičaja V, & Antunović Z. (2021). Slaughter Indicators, Carcass Measures, and Meat Quality of Lamb Fattened with Spelt (Triticum aestivum spp. Spelta L.). Foods, 10(4), 726.

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