Atellica im high sensitivity troponin 1 assay

Manufactured by Siemens

Sourced in Germany

The Atellica IM High Sensitivity Troponin I assay is a laboratory diagnostic test designed to measure the concentration of troponin I, a protein found in the heart muscle. This assay is intended to provide quantitative measurements of troponin I levels in human serum and plasma samples.

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High-sensitivity troponin-I Atellica IM High-sensitivity assay Atellica

4 protocols using atellica im high sensitivity troponin 1 assay

Siemens Atellica IM High Sensitivity Troponin I Assay

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The Siemens Atellica IM High Sensitivity Troponin I assay (Siemens Healthineers) is a three-site sandwich immunoassay with a limit of detection of 1.6 ng/L and limit of quantification of 2.5 ng/L. The upper reference limit 99th centile was determined in 2007 samples from healthy individuals as 34 ng/L in women, and 53 ng/L in men, with a single threshold of 45 ng/L. In the reference range population, 75% of patients had values greater than the limit of detection. The level where the interassay coefficient of variation is <10% is 6 ng/L.14

Ahmed H.A., Mohamed J., Akuku I.G., Lee K.K., Alam S.R., Perel P., Shah J., Ali M.K., Eskander S., Chung M.H, & Shah A.S. (2022). Cardiovascular risk factors and markers of myocardial injury and inflammation in people living with HIV in Nairobi, Kenya: a pilot cross-sectional study. BMJ Open, 12(6), e062352.

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Siemens Atellica IM Troponin I Assay

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The Siemens Atellica IM High Sensitivity Troponin I assay (Siemens Healthineers) is a three-site sandwich immunoassay with a limit of detection of 1.6 ng/L and limit of quantification of 2.5 ng/L. The upper reference limit 99th centile was determined in 2007 samples from healthy individuals as 34 ng/L in women, and 53 ng/L in men, with a single threshold of 45 ng/L. In the reference range population, 75% of patients had values greater than the limit of detection. All measurements were undertaken by Siemens Healthineers at a central laboratory, who were blinded to all clinical information with results provided to the research team and linked to the trial database for analysis.

Chapman A.R., Fujisawa T., Lee K.K., Andrews J.P., Anand A., Sandeman D., Ferry A.V., Stewart S., Marshall L., Strachan F.E., Gray A., Newby D.E., Shah A.S, & Mills N.L. (2018). Novel high-sensitivity cardiac troponin I assay in patients with suspected acute coronary syndrome. Heart, 105(8), 616-622.

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Standardized Cardiac Troponin I Assay

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Blood samples for each phase were handled according to a standardized protocol. Fasting venous blood samples were collected, centrifuged, and serum was stored in aliquots at − 80 °C until batch analysis was performed. Cardiac troponin I concentrations were measured using Siemens Atellica IM High Sensitivity Troponin I assay (Siemens Healthineers, Erlangen, Germany). This assay has a limit of blank of 0.5 ng/L, limit of detection of 1.6 ng/L and a limit of quantitation (LoQ) of 2.5 ng/L. The sex-specific 99^th percentiles are 34 ng/L and 53 ng/L in women and men, respectively.

Kimenai D.M., Anand A., de Bakker M., Shipley M., Fujisawa T., Lyngbakken M.N., Hveem K., Omland T., Valencia-Hernández C.A., Lindbohm J.V., Kivimaki M., Singh-Manoux A., Strachan F.E., Shah A.S., Kardys I., Boersma E., Brunner E.J, & Mills N.L. (2023). Trajectories of cardiac troponin in the decades before cardiovascular death: a longitudinal cohort study. BMC Medicine, 21, 216.

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Cardiac Troponin Assay Performance in Diverse Population

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This study examined the performance of high-sensitivity cardiac troponin assays in a diverse population in the MedStar Health System, which encompasses 10 hospitals throughout the District of Columbia and Baltimore, with diverse clinical contexts. In brief, this was a retrospective, multicenter, observational study of 1,975 patients (older than 18 years of age) for whom an hs-cTnI assay was ordered at the discretion of the treating physician in the ED, observational, or inpatient setting from June 2020 to September 2020. The MedStar Health System uses the Siemens Atellica IM High Sensitivity Troponin I assay (Siemens Healthineers).20 Patients were identified through a query of the MedStar Health System electronic health record (EHR) system, record abstractions were performed, and abstracted data were deidentified. The study methods were approved by the Georgetown University Institutional Review Board.

Kumar S., Griffith N., Walter D., Swett M., Raman V., Vargas J.D., Deb B., Chou J., Arafat A, & Srichai M.B. (2023). Characterization of Myocardial Injury With High-Sensitivity Troponin. The Texas Heart Institute Journal, 50(6), e238108.

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