Within 2–5 days after DBS electrode implantation, intracerebral LFPs were recorded while the patient was at rest and seated. The recordings were performed before turning on the HB–DBS. For each patient, 5-minute resting unipolar LFPs were recorded from four DBS electrode contacts, with a common electrode placed on the surface of the mastoid. The LFPs were recorded using a BrainAmp MR amplifier (Brain Products GmbH, Gilching, Germany) with a sampling rate of 1000 Hz. For each electrode, three-channel bipolar LFPs involving four unipolar recordings were obtained. Here, we focus on the LFPs recorded from the HB contacts that were used for postoperative therapeutic optimization and continuous stimulation.
The location of the electrodes was reconstructed based on preoperative MRI and postoperative CT. The calculation and 3D visualization (Supplementary Fig.1 ) were performed by the Lead-DBS toolbox (Horn et al., 2015, [3 (link)]). LFP recordings were obtained from 6 out of 7 patients who enrolled in the study because one patient preferred not to participate in the electrophysiological examination. Overall, a total of 12 LFP recordings (6 recordings from the left HB electrode and 6 from the right HB electrode) were used for analysis of LFP oscillatory activities.
The location of the electrodes was reconstructed based on preoperative MRI and postoperative CT. The calculation and 3D visualization (Supplementary Fig.