Theophylline anhydrous was purchased from Sigma Aldrich. Compritol® 888 ATO, Precirol® ATO 5 and Geleol™ were gift samples from Gattefosse (NJ, USA). The binders HPC SL and HPC SSL (hydroxy propyl cellulose) were purchased from Nisso America Inc. (Nippon soda, NY, USA). Klucel™ EF (hydroxy propyl cellulose) was supplied by Ashland (DE, USA). Kollidon® VA 64 was supplied by BASF (USA). The diluents Avicel PH® 102 and Avicel® DG (microcrystalline cellulose) were gift samples from FMC Biopolymer (USA). Magnesium stearate was purchased from Alfa Aesar (USA). All the other chemicals employed in this study were of analytical grade.
Anhydrous theophylline
Manufactured by Merck Group
Sourced in United States, Italy, Germany, United Kingdom
Anhydrous theophylline is a crystalline compound that is used as a laboratory reagent. It is a xanthine derivative that can be utilized in various analytical and research applications.
Automatically generated - may contain errors
Lab products found in correlation
Magnesium stearate, by Thermo Fisher Scientific (2 mentions)
Avicel ph102, by FMC Biopolymer (2 mentions)
Avicel dg, by FMC Biopolymer (1 mentions)
Geleol, by Gattefosse (1 mentions)
Klucel ef, by Ashland (1 mentions)
Kollidon va64, by BASF (1 mentions)
Precirol ato 5, by Gattefosse (1 mentions)
Compritol 888 ato, by Gattefosse (1 mentions)
Diclofenac sodium salt, by Merck Group (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Diiodomethane, by Merck Group (1 mentions)
P aminobenzoic acid paba, by Merck Group (1 mentions)
Hplc grade acetonitrile, by Merck Group (1 mentions)
Methanol, by Merck Group (1 mentions)
Ammonium acetate, by Merck Group (1 mentions)
Milli q system, by Merck Group (1 mentions)
Potassium phosphate monobasic, by Thermo Fisher Scientific (1 mentions)
Potassium chloride (kcl), by Thermo Fisher Scientific (1 mentions)
Hydrochloric acid (hcl), by Thermo Fisher Scientific (1 mentions)
Sodium hydroxide (naoh), by Thermo Fisher Scientific (1 mentions)
5 protocols using anhydrous theophylline
1
Theophylline Anhydrous Formulation Development
2
Formulation of Theophylline Tablets
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Theophylline anhydrous (≥99% pure) was purchased from Sigma-Aldrich (St. Louis, MO, USA). Hydroxypropyl cellulose (HPC, Klucel LF) and ethyl cellulose (EC, Aqualon EC N14) were donated by Ashland Inc. (Covington, KY, USA). Croscarmellose sodium (Ac-Di-Sol®) and microcrystalline cellulose (Avicel PH® 102) were provided by FMC Biopolymer (Newark, DE, USA). Magnesium stearate was purchased from Alfa Aesar (Tewksbury, MA, USA). All other reagents and chemicals used were of analytical grade.
3
Solubility and Polymer Blend Characterization
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Eudragit L100-55 (EUD) was generously donated by Degussa (Darmstadt, Germany). Diclofenac sodium salt (DICLO, average molecular weight 318.13 g/mol), anhydrous theophylline (THEOP, average molecular weight 180.16 g/mol) and Dimethylsulfoxide (DMSO, purity 99.5%) were purchased by Sigma-Aldrich (Milan, Italy). CO2 (purity 99%) was supplied from Morlando Group s.r.l. (Sant’Antimo - NA, Italy). All materials were used as received. The solubility in DMSO at room temperature is approximately 55 mg/mL for EUD, 150 mg/mL for DICLO and 25 mg/mL for THEOP.
4
Milk Composition Analysis Protocol
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Fresh commercial milks (Mimosa, Lactogal Produtos Alimentares S.A., Portugal) with different fat contents (per 250ml), Low Fat Milk (LFM -0.3g), Middle Fat Milk (MFM -4.0g) and High Fat Milk (HFM -9.0g), were used in the study. Anhydrous theophylline, diiodomethane, p-aminobenzoic acid (PABA) and acetonitrile (HPLC grade) were all from Sigma Life Science (Germany); ammonium acetate (Merck, Germany) and methanol (Fischer Chemical, USA). Deionized water (W, 18.2MΩ.cm, Milli-Q system, Merck Millipore, USA) was used throughout the study. All other reagents were of analytical grade.
5
Theophylline Release from HPMC Matrices
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HPMC E chemistry grades METHOCEL™, E50LV, E4M and E10M supplied by Colorcon UK were used as the hydrophilic matrix formers. Anhydrous theophylline was obtained from Sigma, UK. Dissolution buffers were prepared according to the USP 2003 [33] using the following materials: potassium chloride (Acros Organics, UK) and hydrochloric acid (Fisher Scientific, UK) for dissolution media at pH 1.2 and pH 2.2; potassium phosphate monobasic-(Fisher BioReagents, UK) and sodium hydroxide (Fisher Scientific, UK) for dissolution media at pH 5.8, 6.8, 7.2 and 7.5 .
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