Sense flex m coil

Magnetic Resonance Imaging (MRI) examinations were performed in all dogs with a 1.5 T system (Intera; Philips Medical Systems) before PAE as baseline data and 1 week, 2 weeks and 1 month after PAE to assess the morphologic responses and measure the PV. Under general anesthesia, the animals were placed in a supine position with a SENSE-Flex-M coil (Philips Medical Systems) around the lower abdomen for image acquisition. A typical MRI examination included axial T1-weighted turbo spin-echo and T2-weighted turbo spin-echo images with a field of view of 14 × 14 cm and a 3 mm section thickness in a 232 × 232 matrix. An additional contrast enhanced T1-weighted imaging was also obtained by intravenous administration of a bolus of 0.1 mmol/kg gadopentetate dimeglumine (Magnevist®; Shering AG). All the imaging data were collected for subsequent imaging analysis by two investigators (F.S and V.L.C).

MR image acquisition was performed at Fukuoka Dental Collage. All the examinations were performed on a 1.5 T scanner (Intera Achieva nova dual; Philips Medical Systems, Eindhoven, the Netherlands) that used a sensitivity‐encoding SENSE‐Flex‐M coil. The muscle functional acquisitions were contiguous 4‐mm axial scans collected from the cricoid to the hard palate utilizing a spin‐echo sequence with a repetition time (TR) of 2000 ms and dual echo times (TE) of 10, 20, 30, 40, 50, 60, 70, and 80 ms. We obtained the T2 maps using the fast spin‐echo (FSE) sequence before, during, immediately after, and 20 min after clenching.
T2‐weighted MR images were obtained before and immediately after each motor task (at rest and after clenching) to measure any changes in the T2 values of the masseter muscles induced by clenching (Figure 1a,c). An average T2 of the anatomic region of interest (ROI) was determined by digitizing the region of the enhanced masseter muscle, which provided a computer‐generated average of T2. Digitizing was performed by one investigator (M.A.). Muscle segmentation was carried out using Osirix (v.3.9.4 32‐bit), a software program for digital imaging and communication in medicine.

MRI experiments were performed on a 3T clinical MR scanner (Philips Achieva, Best, The Netherlands) and images were acquired using SENSE-flex-M coil (Philips Achieva, Best, The Netherlands). From MRI tests, R₁ and R₂ relaxation rates and corresponding r₁ and r₂ relaxivities were calculated [44 (link)]. MPI measurements were performed using the Philips pre-clinical demonstrator system and relevant parameters of the SPION were determined including the signal-to-noise ratio (SNR) and the full width at half maximum (FWHM) of the point spread function (PSF). In order to evaluate hyperthermia performance, a custom-build setup (Trumpf Hüttinger, Freiburg, Germany) was employed and the heating efficiency of the different SPION formulations under an alternating magnetic field (AMF) was quantified using the specific absorption rate (SAR), which provides a measure of the magnetic power absorbed per unit mass of the magnetic material (see Additional file 1 for more details).