Cardiophase

Manufactured by Siemens

Sourced in Germany, United States

CardioPhase is a laboratory equipment product from Siemens. It is designed for cardiac function analysis.

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Lab products found in correlation

Chod pap, by Roche (3 mentions) Gpo pap, by Roche (3 mentions) Glucose god pap, by Roche (2 mentions) Variant 2, by Bio-Rad (2 mentions) Hdl c, by Roche (2 mentions) Labchart, by ADInstruments (1 mentions) Advia 2400, by Siemens (1 mentions) Immulite 2000, by Siemens (1 mentions) Acetonitrile, by DiaSorin (1 mentions)

Close spelling variants of this product

N‐latex CRP II/CardioPhase hsCRP CardioPhase hsCRP kit CardioPhase hsCRP assay CardioPhase® hs-CRP reagents kits CardioPhase hsCRP CardioPhase High Sensitivity C-Reactive Protein Immunoassay

11 protocols using cardiophase

Evaluating Iron Deficiency and Inflammation in COPD

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Blood samples were obtained from all patients at the start of the study protocol. Serum ferritin levels, transferrin saturation, iron levels, and haemoglobin levels were measured in the patients from the Golnik cohort. Subjects were considered iron deficient (ID-COPD) when either absolute iron deficiency (ferritin <100 ng/ml) or functional iron deficiency (ferritin 100–300 ng/ml and transferrin saturation <20%) was present^{22 (link)}. Other patients were defined as non-iron deficient (NID-COPD) patients
Serum CRP was determined as a marker for systemic inflammation with the CardioPhase® high-sensitive CRP kit (Siemens Healthcare Diagnostics Inc., Newark, USA) with a lower limit of detection of 0.18 mg/L, in the COPD patients from the Maastricht cohort^{50 (link)}. Subjects were considered to have low CRP when CRP ≤ 3.0 mg/L and high CRP when CRP > 3.0 mg/L.

Leermakers P.A., Schols A.M., Kneppers A.E., Kelders M.C., de Theije C.C., Lainscak M, & Gosker H.R. (2018). Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD). Scientific Reports, 8, 15007.

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Blood Sampling and Serum CRP Analysis

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In the morning (8.00–10.00 a.m.), and after an overnight fast of at least 8 h, the blood samples were collected and subsequently stored at −80 °C until processed.
Serum high-sensitivity (hs) CRP levels were analyzed by CardioPhase^® (Siemens Healthcare Diagnostics, Marburg, Germany), based on particle-enhanced immunonephelometry. The coefficient of variation (CV) of intra- and interassay was <7%.

Barrea L., Muscogiuri G., Pugliese G., Laudisio D., de Alteriis G., Graziadio C., Colao A, & Savastano S. (2021). Phase Angle as an Easy Diagnostic Tool of Meta-Inflammation for the Nutritionist. Nutrients, 13(5), 1446.

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Blood Sampling and hs-CRP Analysis

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Blood samples were collected between 8.00–10.00 a.m. after an overnight fast (at least 8 h), and the samples were immediately stored at −80 °C until the assay. hs-CRP levels were assessed by a high-sensitivity nephelometric assay (CardioPhase, Siemens Healthcare Diagnostics, Marburg, Germany). The CV of intra- and interassay was <7%.

Barrea L., de Alteriis G., Muscogiuri G., Vetrani C., Verde L., Camajani E., Aprano S., Colao A, & Savastano S. (2022). Impact of a Very Low-Calorie Ketogenic Diet (VLCKD) on Changes in Handgrip Strength in Women with Obesity. Nutrients, 14(19), 4213.

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Fasting Blood CRP Measurement

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Blood samples were collected between 8.00–10.00 a.m. after an overnight fast of at least 8 h, and subsequently stored at −80 °C until processed. High-sensitivity (hs)-CRP levels were determined by a high-sensitivity CardioPhase nephelometric assay of Siemens Healthcare Diagnostics (Marburg, Germany). The CV of intra- and interassay was <7%.

Barrea L., Muscogiuri G., Aprano S., Vetrani C., de Alteriis G., Varcamonti L., Verde L., Colao A, & Savastano S. (2022). Phase angle as an easy diagnostic tool for the nutritionist in the evaluation of inflammatory changes during the active stage of a very low-calorie ketogenic diet. International Journal of Obesity (2005), 46(9), 1591-1597.

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Biomarker Profiling in Metabolic Health

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The blood samples were frozen (− 80 °C) and then assayed in batch. C-Reactive protein (CRP) was measured from plasma using the Siemens CardioPhase hsCRP assay on the BN ProSpec Nephelometer (Siemens Healthcare Diagnostics Products GmbH, Marburd, Germany). The minimal detectable hsCRP concentration was 0.18 mg/L. Lipids and glucose were assayed using respective reagent Flex on the multianalyzer Dimension RxL Max (Dade Behring Diagnostics, Marburg, Germany) with heparinized plasma. To measure waist circumference (WC), the participant’s waistline was exposed and the bottom of a measuring tape was aligned with the top of the hip bone and stretched across the midsection over the navel [50 (link)]. Blood pressure was obtained during a 5-min continuous reading at rest using a Finometer (Finapres Finometer, Amsterdam, the Netherlands) and analyzed offline in LabChart (ADInstruments, Oxford, UK). The mean arterial pressure was used for statistical analyses.

Starnino L., Dupuis G., Busque L., Bourgoin V., Dubé M.P., Busseuil D, & D’Antono B. (2021). The associations of hostility and defensiveness with telomere length are influenced by sex and health status. Biology of Sex Differences, 12, 2.

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Measuring Serum hsCRP Levels

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Serum high-sensitivity C-reactive protein (hsCRP) was measured using particle-enhanced immunonephelometry with CardioPhase^® hsCRP on a BN ProSpec System (Siemens Healthcare Diagnostics, Liederbach, Germany). Both the lower limit of detection and lower limit of quantification were equal to 0.175 mg/L according to the manufacturer's instructions.

Chailurkit L.O., Sritara P., Vathesatogkit P., Yamwong S., Thongmung N, & Ongphiphadhanakul B. (2021). Vitamin D epimers are associated with circulating haemoglobin levels independently of C-reactive protein. Scientific Reports, 11, 20747.

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Measuring High-Sensitivity CRP Levels

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In a subgroup of participants (n = 207), information on c-reactive protein (CRP) was retrieved from electronic medical records. During each visit, fasting blood samples were collected in the morning (8.00–10.00 a.m.), and stored at − 80 °C until processing. Serum high-sensitivity (hs) CRP concentrations were analyzed by CardioPhase^® (Siemens Healthcare Diagnostics, Marburg, Germany), based on particle-enhanced immunonephelometry. The CV of intra-and interassay was < 7%.

Vetrani C., Verde L., Savastano S., Colao A., Muscogiuri G, & Barrea L. (2023). Supplementation with medium-chain fatty acids increases body weight loss during very low-calorie ketogenic diet: a retrospective analysis in a real-life setting. Journal of Translational Medicine, 21, 29.

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Comprehensive Plasma Biomarker Profiling

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The following plasma measurements were performed: glucose (Glucose GOD-PAP, Roche Diagnostics, Mannheim, Germany, coefficient of variation 1.7%, range 241 mg/dL), total cholesterol (CHOD-PAP, Roche Diagnostics, Mannheim, Germany, coefficient of variation 4.0%, range 318 mg/dL), triglycerides (GPO-PAP, Roche Diagnostics, Mannheim, Germany, coefficient of variation 6.4%, range 117 mg/dL), high-density lipoprotein cholesterol (HDL-C) (HDL-C without sample pre-treatment, Roche Diagnostics, Mannheim, Germany, coefficient of variation 4.1%, range 74 mg/dL), HbA1c (Variant II, Bio-Rad Laboratories, Hercules, CA, USA), high-sensitivity C-reactive protein (CRP) (Cardiophase, Dade Behring, Marburg, Germany, coefficient of variation 6.7%, 13.8 g/L). Low-density lipoprotein cholesterol (LDL-C, range 280 mg/dL) was calculated by the Friedewald formula. Technicians, who were blinded to the statin treatment, performed all laboratorial analyses.

Sposito A.C., Carvalho L.S., Moura F.A., Campos-Staffico A.M., Cintra R.M., Nadruz W., Almeida O.R, & Quinaglia e Silva J.C. (2019). Statin Short-term Inhibition of Insulin Sensitivity and Secretion During Acute Phase of ST-Elevation Myocardial Infarction. Scientific Reports, 9, 16401.

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Lipid Profile Changes in STEMI Patients

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Among STEMI patients, blood samples were obtained in the first 24 h from MI symptoms in order to avoid the reported lipid profile changes that occur after this time window [11] (link). Among controls, blood samples were obtained at admission. Blood samples with EDTA were centrifuged after collection at 5 °C and at 4500 rpm for 15 min to separate plasma and cells. Biochemical analyses were performed in duplicates. An automatic chemical analyzer was used to do the following analysis: C-reactive protein (CRP; high-sensitivity assay, Cardiophase, Dade Behring, Marburg, Germany), total cholesterol (CHOD-PAP, Roche Diagnostics, Mannheim, USA), high-density lipoprotein cholesterol (HDL-C, Roche Diagnostics, Mannheim, USA), triglycerides (GPO-PAP, Roche Diagnostics, Mannheim, USA), urea and creatinine (GLDH, Hitachi, Tokyo, Japan). Low-density lipoprotein cholesterol (LDL-C) was calculated using the Friedewald formula. Glomerular filtration rate (GFR) was estimated by abbreviated MDRD equation: Estimated GFR (mL/min/1.73 m²) = 186 × (creatinine/88.4)^− 1.154 × (age) ^− 0.203 × (0.742, if female) × (1.210, if black) [12] (link).

Campos A.M., Placido-Sposito A., Freitas W.M., Moura F.A., Guariento M.E., Nadruz W J.u.n.i.o.r., Moriguchi E.H, & Sposito A.C. (2016). ST-elevation myocardial infarction risk in the very elderly. BBA Clinical, 6, 108-112.

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Comprehensive Metabolic Profiling Protocol

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Twelve-hour fasting plasma samples with EDTA were collected at admission and were immediately subjected to biochemical analyses in duplicates using an automatic chemical analyzer (Hitachi 917, Roche-Diagnostics). Glucose (Glucose GOD-PAP, Roche Diagnostics, Mannheim, USA), total cholesterol (CHOD-PAP, Roche Diagnostics, Mannheim, USA), triglycerides (GPO-PAP, Roche Diagnostics, Mannheim, USA), high-density lipoprotein cholesterol (HDL-C) (Roche Diagnostics, Mannheim, USA), high sensitivity C-reactive protein (CRP) (CardioPhase, Dade Behring, Marburg, USA), HbA1c (Variant II, Bio-Rad Laboratories, Hercules, CA, USA), apolipoprotein (apo) AI and B (Behring Nephelometer BNII, Dade Behring, Marburg, Germany) and plasma zinc (Atomic Absorption Spectrometry) were measured. Intra and interassay coefficients of variation for plasma zinc were 2.5% and 5.4%, respectively.

De Paula R.C., Aneni E.C., Costa A.P., Figueiredo V.N., Moura F.A., Freitas W.M., Quaglia L.A., Santos S.N., Soares A.A., Nadruz W J.r., Blaha M., Blumenthal R., Agatston A., Nasir K, & Sposito A.C. (2014). Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly. BBA Clinical, 2, 1-6.

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