Ccr2 b6.129s4 ccr2tm1ifc j mice

Manufactured by Jackson ImmunoResearch

Ccr2−/− (B6.129S4-Ccr2tm1Ifc/J) mice are a genetically modified mouse strain with a targeted deletion of the Ccr2 gene. The Ccr2 gene encodes the chemokine receptor CCR2, which is involved in the migration and function of monocytes and macrophages. These mice lack the expression of the CCR2 receptor and are a useful model for studying the role of CCR2 in various biological processes.

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Lab products found in correlation

Wild type c57bl 6 mice, by Charles River Laboratories (1 mentions) Cd45.1 b6 sjl ptprca pepcb boyj mice, by Jackson ImmunoResearch (1 mentions)

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B6.129S4-Ccr2tm1Ifc/J (35 citations) Ccr2−/− mice (28 citations) B6.129S4-Ccr2tm1Ifc/J (CCR2 KO) mice (2 citations)

2 protocols using ccr2 b6.129s4 ccr2tm1ifc j mice

Characterization of Ccr2-Deficient Mice

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C57BL/6 wild-type (WT) mice were purchased from Charles River in Beijing (Vital River). Ccr2^−/− (B6.129S4-Ccr2tm1Ifc/J) mice were purchased from Jackson Laboratory. All mice (8 weeks old) were housed in a pathogen-free facility of the Beijing Institute of Lifeomics. All experiments were conducted under protocols approved by the Animal Care and Use Committee (IACUC-20200221-02M).

Hou F., Wang H., Zheng K., Yang W., Xiao K., Rong Z., Xiao J., Li J., Cheng B., Tang L, & Xie L. (2023). Distinct Transcriptional and Functional Differences of Lung Resident and Monocyte-Derived Alveolar Macrophages During the Recovery Period of Acute Lung Injury. Immune Network, 23(3), e24.

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Murine Models for Immunological Research

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C57BL/6 (6 to 10 weeks old) mice were bred and maintained under specific pathogen-free conditions in the BRC of A*STAR (Agency for Science, Technology and Research), Singapore. Both males and females were used for experiments, and animals were gender- and age-matched in each experiment. CD45.1 (B6.SJL-Ptprc^a Pepc^b/BoyJ) mice and Ccr2^−/− (B6.129S4-Ccr2^tm1Ifc/J) mice were obtained from the Jackson Laboratory. Tlr4^−/− (IMSR_OBS:4) mice were obtained from Oriental BioService. Fucci-474Bsi-Green (B6.B6D2-Tg(Fucci)474Bsi) mice were obtained from the RIKEN BioResource Center (Ibaraki, Japan) (76 (link)). LysM-GFP⁺ (Lyz2^tm1.1Graf) mice were provided by T. Graf (Centre for Genomic Regulation, Barcelona, Spain). Ms4a3^creRosa-tdTomato^flox mice were provided by F. Ginhoux (77 (link)). All transgenic mice were maintained on a C57BL/6 background.

Teh Y.C., Chooi M.Y., Liu D., Kwok I., Lai G.C., Ayub Ow Yong L., Ng M., Li J.L., Tan Y., Evrard M., Tan L., Liong K.H., Leong K., Goh C.C., Chan A.Y., Shadan N.B., Mantri C.K., Hwang Y.Y., Cheng H., Cheng T., Yu W., Tey H.L., Larbi A., St John A., Angeli V., Ruedl C., Lee B., Ginhoux F., Chen S.L., Ng L.G., Ding J.L, & Chong S.Z. (2022). Transitional premonocytes emerge in the periphery for host defense against bacterial infections. Science Advances, 8(9), eabj4641.

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