Standards of 3β-25(OH)D3 and 1,25(OH)2D3 were purchased from Cayman Chemical (Ann Arbor, MI, USA); vitamin D3 and (24R)-24,25(OH)2D3 from Toronto Research Chemicals (Toronto, ON, Canada); 3α-25(OH)D3, 4-phenyl-1,2,4-triazoline-3,5-dione, 2-fluoro-1-methylpyridinium-p-toluenesulfonate, isonicotinoyl chloride hydrochloride (95%), nicotinoyl chloride hydrochloride (97%), acetic anhydride (≥ 99%), pyridine (anhydrous, 99.8%), acetonitrile (anhydrous, 99.8%), and 4-dimethylaminopyridine (99%) from Sigma-Aldrich (Steinheim, Germany); acetic acid and triethylamine (≥ 99.5%) from Carl Roth (Karlsruhe, Germany); 4-[2-(6,7-dimethoxy-4-methyl-3-oxo-3,4-dihydroquinoxalinyl)ethyl]-1,2,4-triazoline-3,5-dione from Enzo Life Sciences (NY, USA); 2-nitrosopyridine from MedChemExpress (Monmouth Junction, NJ, USA); Amplifex Diene Reagent Kit from Sciex (Darmstadt, Germany); and 3β-25(ΟΗ)D3-[26,26,26,27,27,27-d6] monohydrate from IsoSciences (Ambler, PA, USA). UHPLC-MS-grade acetonitrile and methanol were obtained from Chemsolute (Th. Geyer, Renningen, Germany) and formic acid (97%) from Alfa Aesar (Karlsruhe, Germany). Organic-free water was generated by a Millipore (Bedford, MA, USA) Direct-Q8 purification system. Human vitamin D3-free serum (VD-DDC Mass Spect Gold® serum) was purchased from Sigma-Aldrich.
Nicotinoyl chloride hydrochloride
Manufactured by Merck Group
Sourced in Canada, United States
Nicotinoyl chloride hydrochloride is a chemical compound commonly used as a laboratory reagent. It is a derivative of nicotinic acid, also known as niacin or vitamin B3. The compound is a crystalline solid with a characteristic odor. It is soluble in various organic solvents and is typically used in chemical synthesis and research applications.
Automatically generated - may contain errors
Lab products found in correlation
Isonicotinoyl chloride hydrochloride, by Merck Group (2 mentions)
Formic acid, by Thermo Fisher Scientific (1 mentions)
4 dimethylaminopyridine, by Merck Group (1 mentions)
4 phenyl 1 2 4 triazoline 3 5 dione, by Merck Group (1 mentions)
Triethylamine, by Carl Roth (1 mentions)
Direct q8 purification system, by Merck Group (1 mentions)
2 nitrosopyridine, by MedChemExpress (1 mentions)
Amplifex diene reagent kit, by AB Sciex (1 mentions)
Vd ddc mass spect gold serum, by Merck Group (1 mentions)
Acetonitrile, by Merck Group (1 mentions)
Acetic anhydride, by Merck Group (1 mentions)
Pyridine, by Merck Group (1 mentions)
Acetic acid, by Carl Roth (1 mentions)
Pyrrolidine, by Merck Group (1 mentions)
Morpholine, by Merck Group (1 mentions)
Cyclohexylamine, by Merck Group (1 mentions)
Triethylamine, by Vetec (1 mentions)
Benzoyl chloride, by Merck Group (1 mentions)
Paragon 1000 ftir spectrophotometer, by PerkinElmer (1 mentions)
4 bromoaniline, by Merck Group (1 mentions)
2 protocols using nicotinoyl chloride hydrochloride
1
Sensitive Vitamin D Metabolite Quantification
2
Synthesis of Nitrogen-Containing Heterocycles
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Analytical grade 1-fluoro-2-nitro-4-trifluoromethyl benzene, piperidine, morpholine, cyclohexylamine, diethylamine, 4-bromoaniline, pyrrolidine, isonicotinoyl chloride hydrochloride, nicotinoyl chloride hydrochloride, 2-chloropyridine-3-carboxylic acid and benzoyl chloride were purchased from Sigma-Aldrich (St. Louis, MO, USA) and used without further purification. Anhydrous tin(II) chloride and triethylamine were purchased from Vetec (Rio de Janeiro, Brazil) and used as received. 1 H NMR and 13 C NMR spectra were recorded on a Varian Mercury 300 instrument (Varian, Palo Alto, CA, USA) at 300 MHz and 75 MHz, respectively, using CDCl 3 and CD 3 OD as solvents. Infrared spectra were recorded on either a Varian 660-IR, equipped with GladiATR scanning from 4000 to 500 cm -1 or a Perkin Elmer Paragon 1000 FTIR spectrophotometer (Perkin Elmer do Brasil Ltda, São Paulo, Brazil), using potassium bromide (1% v/v) disks, scanning from 600 to 4000 cm -1 . Melting points are uncorrected and were obtained with an MQAPF-301 melting point apparatus (Microquimica, Campinas, Brazil). Analytical thin layer chromatography was carried out on TLC plates covered with 60GF254 silica gel. Column chromatography was performed on silica gel (60-230 mesh). Solvents used as eluents were used without further purification.
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