PPT, DPN, MPP, PHTPP, E2, forskolin, genistein, rottlerin, wortmannin, GSK-7975A, ML-9, SKF-96365, CPA, and BAPTA-AM were purchased from MedChemExpress and dissolved in DMSO. CCh and indomethacin were purchased from Sigma-Aldrich. CCh was dissolved in ultrapure water. indomethacin was dissolved in anhydrous alcohol. All salts were supplied by Sangon Biotech and dissolved in ultrapure water.
Gsk 7975a
Manufactured by MedChemExpress
Sourced in United States
GSK-7975A is a selective and potent inhibitor of the enzyme Pim-1 kinase. It has a molecular formula of C₂₄H₂₈N₄O₂ and a molecular weight of 404.50 g/mol. The core function of GSK-7975A is to inhibit the activity of Pim-1 kinase, which is involved in various cellular processes such as cell growth, survival, and differentiation.
Automatically generated - may contain errors
Lab products found in correlation
Skf 96365, by MedChemExpress (3 mentions)
Cyclopiazonic acid, by Merck Group (3 mentions)
Nifedipine, by Merck Group (2 mentions)
Ouabain, by MedChemExpress (2 mentions)
Dantrolene, by Apexbio (2 mentions)
Indomethacin, by Merck Group (1 mentions)
Wortmannin, by MedChemExpress (1 mentions)
Phtpp, by MedChemExpress (1 mentions)
Genistein, by MedChemExpress (1 mentions)
Forskolin, by MedChemExpress (1 mentions)
Rottlerin, by MedChemExpress (1 mentions)
Bapta am, by MedChemExpress (1 mentions)
Carbachol, by Merck Group (1 mentions)
L nna, by Merck Group (1 mentions)
Ouabain, by Apexbio (1 mentions)
Ska 31, by MedChemExpress (1 mentions)
Penicillin streptomycin, by Thermo Fisher Scientific (1 mentions)
Trypsin, by Thermo Fisher Scientific (1 mentions)
Fura 2, by Thermo Fisher Scientific (1 mentions)
Hc067047, by MedChemExpress (1 mentions)
4 protocols using gsk 7975a
1
Ion Channel Modulation Reagents
2
Vascular Signaling Pathway Reagents
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Cyclopiazonic acid, L-NNA, carbachol (CCH), TEA, ACh, and INDO were purchased from Sigma. Ouabain was purchased from ApexBio. SKA-31, SKF96365, and GSK-7975A were purchased from MedChemExpress. SN-6 was purchased from Tocris. The most of the reagents were dissolved in DMSO at final concentration of less than 0.1%, which did not alter vascular activities in the experiments.
3
Pharmacological Modulation of Calcium Signaling
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Prostaglandin E2, Serotonin hydrochloride(5-HT), SKF-96365, TPEN (N, N, N′, N′- tetrakis (2-pyridylmethyl) ethylenediamine), GSK-7975A, ouabain, HC067047, and GSK1016790A were purchased from MedChemExpress (MCE; Monmouth Junction, NJ, United States). Sigma (Saint Louis, MO, United States) supplied carbamylcholine chloride (CCh), nifedipine, gadolinium chloride, and cyclopiazonic acid (CPA). Tocris Bioscience (Ellisville, MO, United States) supplied 2-Aminoethoxydiphenyl borate (2-APB), while APExBIO Technology LLC (Houston, TX, United States) provided dantrolene. Fura-2 was purchased from Invitrogen (UT, United States), meantime DMEM and FBS were obtained from Hyclone (Logan, UT, United States). Trypsin and penicillin/streptomycin were purchased from Gibco (CA, United States). The other chemicals were obtained from BBI Life Science (Shanghai, China).
4
Comprehensive Compound Preparation Protocol
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Sigma (Saint Louis, MO, United States) supplied l -Glutamine, spermine, cyclopiazonic acid (CPA), nifedipine, and gadolinium (III) chloride (GdCl3). GPNA hydrochloride, cinromide, Calhex 231 hydrochloride, NPS-2143, AMG 517, N, N, N′, N′- tetrakis (2-pyridylmethyl) ethylenediamine (TPEN), probenecid, SN-6, ouabain, mibefradil, and GSK-7975A were purchased from MedChemExpress (MCE; Monmouth Junction, NJ). Tocris Bioscience (Ellisville, MO) supplied 2-Aminoethyl diphenylborinate (2-APB), while APExBIO Technology LLC (Houston, TX) provided dantrolene. The other chemicals were obtained from BBI Life Science (Shanghai, China). Gln, Lithium chloride (LiCl), and gadolinium (III) chloride (GdCl3) were dissolved in ultrapure water. Most of the remainder were prepared with dimethyl sulfoxide (DMSO), and the volume ratio was less than 1:1,000, which did not affect the basic current.
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