Amodiaquin dihydrochloride dihydrate

Oseltamivir carboxylate was purchased from MedChemexpress CO., Ltd, (Monmouth Junction, NJ). Lysosomotrophic agents amodiaquin dihydrochloride dihydrate, bafilomycin A from Streptomyces griseus, chloroquine diphosphate salt, quinacrine dihydrochloride, quinidine anhydrous, Mefloquine hydrochloride, and primaquine diphosphate were purchased from Sigma-Aldrich (St-Louis, MO). Quinine sulfate was obtained from Fisher (Fair Lawn, NJ). Calcium modulators calcimycin (A23187), capsaicin, 5-(N,N-Dimethyl) amiloride hydrochloride, and verapamil hydrochoride were purchased from Sigma-Aldrich whereas TMB-8 hydrochloride was purchased from Calbiochem (Mississauga, ON). Mefloquine, calcimycin, bafilomycin A, and capsaicin were dissolved in DMSO (Sigma-Aldrich) in order to have a final solvent concentration of less than 0.1%, whereas other compounds were dissolved in culture medium. At this concentration, DMSO showed no apparent toxicity in MDCK cells (less than 1%, data not shown).

Acetaminophen (catalog number HY-66005), arbidol hydrochloride (HY-14904A), aspirin (HY-14654), atazanavir sulfate (HY-17367A), baloxavir marboxil (HY-109025), daclatasvir (HY-10466), darunavir (HY-17040), dolutegravir (HY-13238), efavirenz (HY-10572), elbasvir (HY-15789), etravirine (HY-90005), galidesivir (BCX4430, HY-18649A), ganciclovir (HY-13637), glecaprevir (HY-17634), hydroxychloroquine (HY-B1370), indomethacin (HY-14397), ledipasvir (HY-15602), lopinavir (HY-14588), losartan (HY-17512), nafamostat mesylate (HY-B0190A), nitazoxanide (HY-B0217), ombitasvir (HY-13997), oseltamivir (HY-13318), penciclovir (HY-17424), perindopril salt (HY-B0130A), raltegravir (HY-10353), remdesivir (GS-5734, HY-104077), rilpivirine (HY-10574), ritonavir (HY-90001), simeprevir (HY-10241), sofosbuvir (HY-15005), and β-d-N4-hydroxycytidine (HY-125033) were purchased from MedChemExpress (Monmouth Junction, NJ, United States). Amodiaquin dihydrochloride dihydrate (A2799), artesunate (A3731), chloroquine phosphate (PHR1258), mefloquine hydrochloride (PHR1705), peramivir trihydrate (SML2486), ribavirin (R9644), teicoplanin (T0578), and toremifene citrate salt (T7204) were purchased from Sigma-Aldrich (St, Louis, Missouri, United States). Favipiravir (T-705) was provided by the Toyama Chemical Co., Ltd. (Japan). The drug solutions were filtered through a 0.22 μM membrane and were stored at −80°C.