The Eclipse treatment planning system, version 13.6 (Varian Inc., Palo Alto, CA, USA), was used for this study. A copy of the original HDL plan was created in Eclipse and the linac was changed from the HDL to the SDL in the plan properties. This process automatically removes the dynamic MLC positions defining the control point apertures stored in the plan. A new MLC object was then added to each field (VMAT arc) in the SDL plan, and the number of control points was set by the user to match the original number found in the HDL fields. The TPS template method provides the beam modeling data required to calculate dose correctly for the SDL.
Eclipse treatment planning system version 13
Manufactured by Agilent Technologies
Sourced in United States
The Eclipse treatment planning system version 13.6 is a software tool designed for radiation therapy planning. It provides functionality for managing patient data, defining treatment targets, and calculating radiation dose distributions.
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Lab products found in correlation
6 protocols using eclipse treatment planning system version 13
1
Transitioning HDL to SDL Treatment Plans
2
Volumetric Modulated Arc Therapy for Breast Cancer
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VMAT plans were generated using 2 coplanar arcs. To decide upon the geometry of these arcs, first, the gantry angle at which the projected separation of the PTV in the beam’s eye view (BEV) was found to be the largest was chosen. Since treatment volumes tend to be large and due to limitations of MLC leaf travel, on certain LINACS as being 15 cm, coverage of the PTV had to be split into two arcs. These arcs overlapped at the isocenter by 2 cm and were within a 200° range. The collimator angle was kept at 0°. Details regarding the field arrangement have been published elsewhere [8 (link)]. All treatment plans were performed with the Eclipse treatment planning system version 13.6 (Varian Medical Systems, Palo Alto, USA). The anisotropic analytical algorithm (AAA) was used for dose calculation. The optimization algorithm used was the Progressive Resolution Optimizer (PRO). During optimization, priority was given to cover 95% of the IMNs with at least 90% of the prescription dose (i.e 45 Gy) or more while achieving D95, V95 ≥ 95% and D5 ≤ 115% for the PTV, followed by mean heart dose (MHD), ipsilateral lung V20 Gy and dose to the contralateral lung and breast/implant.
3
VMAT Radiation Therapy Protocol
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The treatment was delivered using VMAT with two full arcs. Every patient was treated with a full bladder and empty rectum as per local clinical protocol. The intent of the radiation therapy was curative for all patients. Treatment plans were created in the external beam planning module of the eclipse treatment planning system, version 13.6 (Varian Medical System, Palo Alto, CA, USA). Dose and dose‐volume objectives for the radiation treatment are summarized in Table 1 . The beam energy and the maximum dose rate for both arcs were 6MV and 1000MU/min (SRS mode). All the non‐ART plans were normalized to the dose received by 95% of the PTV volume. Specifically, the dose was determined based on the 95% of the PTV volume on the dose volume histogram of the original treatment plan. The non‐ART plans were not normalized.
4
Stereotactic Body Radiation Therapy for Liver Tumors
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The HCC SBRT were delivered using Truebeam (Varian Medical Systems, Palo Alto, CA) flattening filter free mode via volumetric modulated arc therapy. The diaphragm, lipiodol, or fiducial markers were used as surrogates for the tumors. The amplitude of the movement of the surrogates was limited to less than 1 cm by either active breathing control or abdominal compressor. The internal target volume was generated as a union of gross tumor volume (GTV) of all phases of 4-dimensional computed tomography. The planning target volume (PTV) was generated by adding 5 to 10 mm margin to the internal target volume. The treatment plans were generated using Eclipse Treatment Planning System version 13.6 (Varian Medical Systems, Palo Alto, CA). Anisotropic Analytical Algorithm version 13.6.23 was used to perform dose calculation. The prescription dose ranged from 27.5 Gy to 50 Gy in 5 fractions depending on the normal liver (excluding all GTVs) mean dose, following the Radiation Therapy Oncology Group (RTOG) 1112 dose prescription approach.11 For a typical treatment plan, the isodose line of 80% was used for dose prescription and the center of the GTV was boosted to around 100% isodose line. The dose constraints to organs at risk were also adopted following RTOG 1112.
5
Interobserver Reliability in Parotid Delineation
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Retrospective data of HNC patients who underwent intensity-modulated radiation therapy and volumetric modulated arc therapy between 2017 and 2022 were included in this study. Note that only patients with CT images free from artifacts were included. From the initial pool of 200 patients, 20 patients were randomly selected for the interobserver reliability test. The CT images were acquired during the simulation stage, and the original delineations of the parotid glands were manually performed during the planning stage by the treating radiation oncologists (ROs) with 3–13 years of experience. To evaluate interobserver variations, additional manual delineations of the parotid glands were conducted by a selected RO with 15 years’ experience using Eclipse treatment planning system version 13.6 (Varian Medical Systems, Palo Alto, CA, USA), and automated delineations were performed using AccuContour AI-assisted Auto-delineation Tool version 3.1 (Manteia Data Technologies Ltd., Milwaukee, WI, USA).
6
Dose-Escalated Prostate Cancer Radiotherapy
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A sequential (two-phase) treatment regimen was utilized, whereby a dose of 46-54 Gy in 23 to 27 fractions was prescribed to the prostate, seminal vesicles (SVs) and PLNs in Phase 1 (P1). A coned down Phase 2 (P2) volume with a dose of 24 to 28 Gy in 12 to 14 fractions was delivered to the involved SVs and prostate, giving a total of 74 to 78 Gy. Target volumes were defined in accordance to the departmental contouring guide for standard RT of the prostate and PLNs, whilst OARs were referenced to the Radiation Therapy Oncology Group consensus panel atlas. 12 Clinical target volumes were defined as the entire prostate with SVs and for the PLNs, the superior border was at the L5/S1 interspace, including the distal common iliac, internal and external iliac nodes; presacral nodes were not routinely included. For both P1 and P2, planning target volumes were created from Clinical target volumes by using a margin expansion of 5 mm posteriorly and 5 to 8 mm in all other directions. Dual arc volumetric modulated arc therapy plans with 10 MV energy and a maximum dose rate of 600 Monitor Units/min were generated for P1 and P2 using the Eclipse treatment planning system version 13.6 (Varian Medical Systems). Final dose calculations were undertaken using an Anisotropic Analytical Algorithm with a dose calculation grid size of 2.5 mm.
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