Somaton definition as

Manufactured by Siemens

Sourced in Germany

The Somaton Definition AS is a computed tomography (CT) imaging system developed by Siemens. It is designed to capture high-quality images of the body's internal structures. The Somaton Definition AS utilizes advanced imaging technology to provide detailed visualizations for diagnostic and clinical applications.

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Lab products found in correlation

Discovery hd 750, by GE Healthcare (1 mentions) Lightspeed vct, by GE Healthcare (1 mentions) Somatom force, by Siemens (1 mentions) Lunar idxa, by GE Healthcare (1 mentions) μct100, by Scanco (1 mentions) 1.5t system, by GE Healthcare (1 mentions)

10 protocols using somaton definition as

Optimizing Radiation Exposure in Pulmonary Embolism CT

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To remove the potential effect of case mix (that is, different reasons why patients underwent CT), we illustrated the variation in effective doses for one specific imaging indication: suspected pulmonary embolism. We also did a subanalysis for this indication using data from one machine model (Somaton Definition AS, Siemens Healthineers) to illustrate representative differences in technical parameters chosen by institutions for this indication and on this scanner. The main analyses were repeated using volumetric CT dose index as the outcome, and restricting to single phase CT examinations. We compared doses in the registry to published benchmarks, extracting combined data across age, sex, and size categories.3
4 (link)
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25 (link)
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28 We abstracted effective doses from published reports, or calculated these from dose length product values using published conversion factors.22 (link)

Smith-Bindman R., Wang Y., Chu P., Chung R., Einstein A.J., Balcombe J., Cocker M., Das M., Delman B.N., Flynn M., Gould R., Lee R.K., Nelson T.R., Schindera S., Seibert A., Starkey J., Suntharalingam S., Wetter A., Wildberger J.E, & Miglioretti D.L. (2019). International variation in radiation dose for computed tomography examinations: prospective cohort study. The BMJ, 364, k4931.

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Contrast-Enhanced CT Imaging Protocol

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CT images were acquired using 64-slice SOMATON Definition AS (SIEMENS). CT scans were acquired at full inspiration. The contrast material iohexol (Beijing Beilu Pharmaceutical Co., Ltd.) was injected into the antecubital vein at a rate of 3.5 mL/s (1.2 mL/kg of body weight, less than 70 mL in total). The parameters of the CT scan were as follows: the tube voltage was 120 KV, the tube current was automatically adjusted, the matrix was 512 × 512, the field of view (FOV) was 403 mm×403 mm, and the reconstructed slice thickness was 1.25 mm. Plain scan (PS), arterial phase (AP) and venous phase (VP) images were obtained. AP and VP scans were acquired 25 and 60 s after the contrast injection, respectively.

Tang W., Wen C., Pei Y., Wu Z., Zhong J., Peng J, & Zhong J. (2023). Preoperative CT findings and prognosis of pulmonary sarcomatoid carcinoma: comparison with conventional NSCLC of similar tumor size. BMC Medical Imaging, 23, 105.

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Lung SBRT Imaging Protocol

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All the phantom cases and patients received a 4DCT and a series of CBCT
scanning. The 4DCT for patients was acquired with the assistance of RPM
system accurate treatment planning. Multiple CBCT scans for position
verification were conducted during the lung SBRT treatment. The CBCT images
acquired at the first time were used for tumor delineation in case the
patient body shape and tumor volume change during SBRT treatment. Patients
were trained to keep consistent breathing during 4DCT and CBCT
acquisition.
The 4DCT images were acquired on a Siemens Somaton Definition AS CT scanner
with a pitch of 1.5 and a slice thickness of 1 mm. Free-breath CT
(4DCT_FB) was acquired with the white ball moving smoothly in
phantom or patients breathing calmly during scanning. Averaged CT
(4DCT_AVG) is the averaged scan based on all phases of the
4DCT. MIP images (4DCT_MIP) are maximum intensity projection
images with all the tumor motion trajectories been projected onto one CT
image series.
The CBCT image acquisition was performed in a CBCT system embedded in the
Varian Vital Beam Linear Accelerator. The tube exposure setting of CBCT was
100 kVp and 100 mAs. It rotates 360° around the phantom at a speed of 6
degrees per second. Within about 1 min scanning, all the target motion
trajectories were captured.

Li Z., Zhang S., Zhang L., Li Y., Zheng X., Fu J, & Qiu J. (2022). Deep Learning-Based Internal Target Volume (ITV) Prediction Using Cone-Beam CT Images in Lung Stereotactic Body Radiotherapy. Technology in Cancer Research & Treatment, 21, 15330338211073380.

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CT Imaging Protocol for Multimodal Analysis

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All images were obtained on one of the following CT scanners: ① Somaton Definition AS+ (Siemens Healthineers, Germany); ② Neuviz 128 CT (Neuviz Healthcare, China); and ③ Discovery HD 750 and LightSpeed VCT (GE Healthcare, America). The main scanning parameters were as follow: tube voltage = 120 KV; tube current (250 mA −450 mA); pitch (1.0–1.375); spinning speed (0.8 s − 1.0 s), matrix = 512 × 512, slice thickness = 5 mm, FOV = 350 mm × 350 mm. All CT images were reconstructed with a slice thickness and increment of 1.25 mm. All image browsing, multiplanar reformation (MPR) and data measurement were performed using RadiAnt DICOM Viewer 5.5.1.

Wang C., Shi B., Wei C., Ding H., Gu J, & Dong J. (2020). Initial CT features and dynamic evolution of early-stage patients with COVID-19. Radiology of Infectious Diseases (Beijing, China), 7(4), 195-203.

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High-Resolution Chest CT Imaging in Families

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We performed high-resolution chest CT scans in 8 patients (6 in family 1 and 2 in family 2). Chest CT was obtained on different multi-detector (MDCT) scanners, including a 64-slice MDCT equipment (SOMATON Definition AS+, SIEMENS, Healthcare, Forchheim, Germany) and a third-generation, dual source CT scanner (SOMATOM Force, SIEMENS Healthcare, Forchheim, Germany) detectors. The scanning protocol included end-inspiratory and -expiratory acquisitions over the entire thorax. The CT parameters analyzed on lung images included emphysema (i.e., centrilobular, panlobular, bullous), bronchial wall thickening, bronchiectasis and CT features of small airways disease (i.e., bronchiolectases, ill-defined micronodules, mosaic attenuation and air trapping) on lung images.

Meunier I., Bocquet B., Labesse G., Zeitz C., Defoort-Dhellemmes S., Lacroux A., Mauget-Faysse M., Drumare I., Gamez A.S., Mathieu C., Marquette V., Sagot L., Dhaenens C.M., Arndt C., Carroll P., Remy-Jardin M., Cohen S.Y., Sahel J.A., Puech B., Audo I., Mrejen S, & Hamel C.P. (2016). A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene. Scientific Reports, 6, 32544.

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Femoral Neck Bone Density Analysis

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Dual-energy X-ray absorptiometry (DXA) scans of the proximal femoral necks (Lunar iDXA, GE Healthcare, USA) were performed using two water bags of approximately 10 cm thickness to mimic the soft tissues. Each femur was scanned with a quantitative computed tomography device (Somaton Definition AS, Siemens Medical Systems, Germany) with a resolution of 0.48 × 0.48 × 0.6 mm, while a phantom (BDC700, QRM, Germany) allowed a post-calibration of the images in Hounsfield units. The neck sections were scanned with micro-computed tomography (μCT) (μCT 100, Scanco Medical, Switzerland) at 16 μm spatial resolution. The grayscale images were converted into bone mineral densities (BMD) with a calibration equation obtained with a calibration phantom of the manufacturer. Each scan was pre-segmented with its otsu threshold (Otsu, 1979 (link)), and then all the grayscale images were segmented with the average of the individual threshold. The bone masks were obtained with morphological operations (Buie et al., 2007 (link)). The tissue bone mineral density, calculated by averaging the BMD of the segmented volume and prone to partial volume effect, was corrected to be independent of the ratio of the bone surface over bone volume. BV/TV was calculated as the ratio of the segmented bone volume over the total neck volume.

Voumard B., Stefanek P., Pretterklieber M., Pahr D, & Zysset P. (2022). Influence of aging on mechanical properties of the femoral neck using an inverse method. Bone Reports, 17, 101638.

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Three-Phase CT Examination Protocol

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A total of 230 patients took three-phase CT examinations (64 or 128 slice, Somaton Definition AS, Siemens). Enhanced CT was performed based on the technology of computer-assisted bolus tracking, with 90–100 milliliters lopromide being administrated via a power injector at a rate of 3.0mL/s. With a 100Hu threshold of the abdominal aorta at the celiac artery as the baseline, the scanning delay of CMP and NP was 15 seconds and 30 seconds, respectively. The imaging protocols were as follows: tube voltage, 120Kv; tube current, 200mA; collimation, 64*0.625mm; rotation time, 0.75s; field of view, 360mm; slice thickness/interval, 5mm; window width/level, 300Hu/40Hu.

Ma Y., Xu X., Pang P, & Wen Y. (2021). A CT-Based Tumoral and Mini-Peritumoral Radiomics Approach: Differentiate Fat-Poor Angiomyolipoma from Clear Cell Renal Cell Carcinoma. Cancer Management and Research, 13, 1417-1425.

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Triphasic CT for Abdominal Imaging

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Three hundred and seventy patients have taken CT examinations by a 64-slice (133 patients) or 128-slice (237 patients) spiral CT scanner (Siemens, Somaton Definition AS, Munich, Germany). Triphasic CT examination was performed, and the parameters were as follows: tube voltage 120 kVp, tube current 150–200 mA, collimation 64 * 0.625 mm, rotation time 0.75 s, slice thickness 5 mm, interval thickness 5 mm, and nonionic contrast media iomeperol at a rate of 3.0 ml/s with a dose of 1.3 ml/kg. A 100-Hu threshold of the abdominal aorta at the celiac artery was taken as the baseline, then the arterial phase and venous phase were examined 15 and 30 s after the unenhanced phase.

Ma Y., Guan Z., Liang H, & Cao H. (2022). Predicting the WHO/ISUP Grade of Clear Cell Renal Cell Carcinoma Through CT-Based Tumoral and Peritumoral Radiomics. Frontiers in Oncology, 12, 831112.

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Radiological Evaluation of Severe Asthma

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High resolution computerised tomography (HRCT) scans were undertaken in those with severe and/or difficult to treat asthma. Scans of the whole thorax (including both inspiratory and expiratory phases) were obtained using a Siemens Somaton Definition AS plus spiral scanner (Siemens Healthcare, Knoxville, TN). Scans were performed in a caudio-cranial direction using 1mm thickness slices at 0.7mm intervals.
The clinical radiology report was scored by one of the investigators (KW) (blinded to any of the immunological data) for the presence or absence of bronchiectasis, bronchial wall thickness, air trapping, tree-in-bud, mucoid impaction, collapse/consolidation or fibrosis.
Fleeting shadows were recognised by their presence on serial chest x-rays.

Woolnough K.F., Richardson M., Newby C., Craner M., Bourne M., Monteiro W., Siddiqui S., Bradding P., Pashley C.H, & Wardlaw A.J. (2017). The relationship between biomarkers of fungal allergy and lung damage in asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 47(1).

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Fetal MRI and CT Brain Imaging Protocol

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Fetal MRI was performed with a 1.5 -T system (GE Healthcare, Chalfont St Giles, United Kingdom), using an abdomen coil. The MR protocol included fast imaging employing steady-state acquisition, repetition time msec/echo times msec, 3.8/1.7, section thickness 4 mm, intersection gap 4.4 mm, field of view 600-700 mm, matrix 512 x 512), T2-weighted single-shot fast spin-echo images (1240. 54/87. 8, thickness 4 mm, intersection gap 4.4 mm, matrix 512 x 512), T2* gradient-echo (467/15, thickness 4 mm, intersection gap 4.4 mm, matrix 256 x 256) and T1-weighted fast spoiled gradient-recalled acquisition in the steady state (100/2.5, thickness 4 mm, intersection gap 4.4 mm, matrix 512 x 512). We considered parenchymal calcifications at fetal MRI when marked T2-hypointense and T1-hyperintense and/or T2*-hypointense foci were seen at the cortex, basal ganglia, periventricular regions and/or cerebellum. Non-enhanced brain CT scans were performed on a 64-section scanner (SOMATON Definition AS; Siemens Healthcare, Forchheim, Germany), using the spiral technique (total collimation width, 9.2; slice thickness, 1.0 mm; pitch, 0.65). Brain parenchymal thickness was assessed with both CT and MRI at the level of the frontal horns of the lateral ventricles in the frontal regions.

Castro J.D.V., Pereira L.P., Dias D.A., Aguiar L.B., Maia J.C.N., Costa J.I.F.D., Castro E.C.M., Feitosa F.E.L, & Carvalho F.H.C. (2017). Presumed Zika virus-related congenital brain malformations: the spectrum of CT and MRI findings in fetuses and newborns. Arquivos de neuro-psiquiatria, 75(10).

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