5 fluorodeoxyuridine

Manufactured by Thermo Fisher Scientific

Sourced in China

5-Fluorodeoxyuridine is a synthetic pyrimidine nucleoside analog. It functions as a thymidylate synthase inhibitor, which plays a role in DNA synthesis.

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2 protocols using 5 fluorodeoxyuridine

Reagents for Biomolecular Modification

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5-Fluorodeoxyuridine was purchased from Alfa Aesar (Shanghai, China). 4,4ʹ-Dimethoxytrityl Chloride (DMT-Cl, 97%) N,N-Diisopropylethylamine (DIPEA, 97%) and 2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphordiamidite (95%) were obtained from Macklin Inc. (Shanghai, China). N-(ε-malemidocaproyloxy) succinimide ester (EMCS) was purchased from Aladdin (Shanghai, China). Ni-NTA agarose, and Sephadex G-25 were obtained from GE Healthcare (Piscataway, USA). Imidazole, sodium chloride, sodium acetate, polyacrylamide, tris base, acetic acid, ethylenediaminetetraacetic acid (EDTA), magnesium chloride, ethanol, and DAPI were obtained from Sangon Biotech (Shanghai) Co., Ltd (China). Amicon ultracentrifugal filters were purchased from Merck Millipore Ltd (Darmstadt, Germany). RPMI 1640 medium, DMEM medium, MEBM medium, trypsin, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), antibiotic-antimycotic (100×) and fetal bovine serum (FBS) were purchased from Wisent Biotechnology (Nanjing) Co. Ltd (China). All chemicals were used without further purification.

Zhang C., Han M., Zhang F., Yang X., Du J., Zhang H., Li W, & Chen S. (2020). Enhancing Antitumor Efficacy of Nucleoside Analog 5-Fluorodeoxyuridine on HER2-Overexpressing Breast Cancer by Affibody-Engineered DNA Nanoparticle. International Journal of Nanomedicine, 15, 885-900.

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Synthesis and Characterization of Fluorescent Probes

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5-fluorodeoxyuridine (98%, Alfa Aesar, Shanghai, China), 4,4’-Dimethoxytrityl Chloride (DMT-Cl, 97%, Macklin, Shanghai, China), N, N-Diisopropylethylamine (DIPEA, 97%, Macklin), 2-Cyanoethyl N, N, N′, N′-tetraisopropylphosphordiamidite (95%, Macklin), N-(ε-malemidocaproyloxy) succinimide ester (EMCS, 98%, Aladdin, Shanghai, China), pyrene (95%, Aladdin), curcumin (95%, Aladdin) and 2-(4-amidinophenyl)-6-indolecarbamindine dihydrochloride (DAPI, 95%, Sangon Biotech, Shanghai, China) were used as received. CytoPainter LysoRed Indicator Reagent (ab176828) was bought from Abcam Co., Ltd (Boston, MA, USA). Trypsin, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), phosphate-buffered saline (PBS), Dubelcco’s Modified Eagle’s Medium (DMEM), Roswell Park Memorial Institute-1640 (RPMI-1640), antibiotic-antimycotic (100×) and fetal bovine serum (FBS) were purchased from Wisent Biotechnology (Nanjing) Co. Ltd (Nanjing, China). The caspase 3, 8 and 9 activity detection kits were purchased from BestBio Biotechnology Co., Ltd. (Shanghai, China).

Zhang C., Fu S., Zhang F., Han M., Wang X., Du J., Zhang H, & Li W. (2022). Affibody Modified G-quadruplex DNA Micelles Incorporating Polymeric 5-Fluorodeoxyuridine for Targeted Delivery of Curcumin to Enhance Synergetic Therapy of HER2 Positive Gastric Cancer. Nanomaterials, 12(4), 696.

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