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Medrad ecoil

Manufactured by Bayer
Sourced in Germany

The Medrad eCoil is a laboratory equipment product manufactured by Bayer. It is a coil device designed for use in medical and research applications. The core function of the Medrad eCoil is to generate a magnetic field for various purposes, such as imaging or diagnostic procedures. The device specifications and technical details are not available for an unbiased and factual description without further interpretation.

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5 protocols using medrad ecoil

1

Prostate MRI Acquisition Protocol

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A 3-T MRI unit (Achieva, Philips Healthcare) that used a combination of an anterior 16-channel torso-cardiac coil (SENSE, Invivo) and an endorectal coil (Medrad eCoil, Bayer Healthcare) was used for imaging examinations. The prostate MRI protocol included triplane T2-weighted MRI, axial DWI (with evenly spaced b values of 0–750 s/mm2) and an apparent diffusion coefficient map and a high b value DWI with a b value of 2000 s/mm2) and dynamic contrast-enhanced MRI. However, for the analyses, only triplane T2-weighted images were used. The pulse sequences and parameters of the triplane T2-weighted MRI used in the present study are presented in Table S2 (supplemental data, which can be viewed in the AJR electronic supplement to this article, available at www.ajronline.org).
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2

Prostate Lesion Identification via MP-MRI

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Prior to biopsy, patients underwent prostate MP-MRI (consisting of small field of view multiplanar T2-weighted, diffusionweighted, and dynamic-contrast enhanced imaging) with an endorectal coil (BPX-30, Bayer Inc.) on a 3.0T MRI scanner (Achieva, Philips Healthcare) in the original cohort and on either a 1.5T MRI scanner (Magnetom Avanto, Siemens Medical Solutions) with an endorectal coil (MedRad eCoil, Bayer Inc.) or 3.0T MRI scanner (Discovery 750w, GE Healthcare; Magnetom Trio, Siemens Medical Solutions; or Achieva, Philips Healthcare) without an endorectal coil in the independent cohort. MRI images were read by 2 independent readers in the original cohort and 6 independent readers for the independent cohort. Images were segmented and lesion location was recorded (DynaCAD, Invivo). Lesions were scored corresponding to the Prostate Imaging-Reporting and Data System version 2 (PIRADS v2) as low (PIRADS 1-2), moderate (PIRADS 3) or high (PIRADS 4-5) based on the number of positive sequences per lesion in the original cohort. PIRADS v2 was used in the independent cohort. Screen positive lesions (SPLs) were defined as lesions positive on T2-weighted and diffusion weighted imaging sequences on MP-MRI.
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3

Standardized Prostate MRI Acquisition Protocol

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The acquisition parameters used for the study are presented in Table 1.
All prostate MRI examinations were performed with the patient in the supine position using a 1.5 T unit. From 2010 to 2014, the unit used was a Magnetom Sonata, while from 2014 to 2016 it was a Magnetom Symphony (Siemens Healthineers). In both cases, they were equipped with 40 mT/m gradients using a 4-channel surface coil (Body Matrix, A Tim Coil, Siemens Healthineers) and a single-channel ERC (Medrad eCoil, MR Endorectal Coil, Bayer Healthcare, Berlin, Germany).
The mpMRI protocol included: an axial T1-weighted sequence with fat saturation; a three-plane T2WI sequence; an axial echo-planar DWI sequence; and a three-dimensional T1-weighted DCE study.
From 2010 to 2011, gadobenate dimeglumine (MultiHance, Bracco) was used in a dose of 0.1 mM/kg of body weight, immediately followed by 20 mL of saline flush (flow rate of 2 mL/s); whereas, from 2012 to 2016, gadoteridol (Prohance, Bracco) was used in a dose of 0.1 mM/kg of body weight, immediately followed by 20 mL of saline flush (flow rate of 2 mL/s).
The average of the total examination time (including the cannulation and injection of contrast, and the positioning of ERC) for each examination was approximately 45 min.
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4

Rectal MRI with T2 Mapping

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Patients underwent preoperative MRI with a 3T Philips Achieva MR system with a 6-channel cardiac phased array coil placed around the pelvis, and with an endorectal coil (Medrad eCoil, Bayer Healthcare). To limit peristalsis of the rectal wall 1mg dose of Glucagon (Glucagon, Eli Lilly & Co., Indianapolis) was injected prior to imaging. T2W images and multi echo T2W images were acquired, and only patients who underwent T2 mapping were included in the study. The echo times used were 90, 150, and 180 ms. The field-of-view was 160 mm x 160 mm and the matrix size was 212 x 212 with an in-plane resolution of 0.75 x 0.75 mm. The repetition time (TR) was 7.5 ms.
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5

Endorectal Coil Design Comparison

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Solid ERCs consisting of two loop elements (ERC-2L) were built by placing two rectangular loops on a 2.2 cm diameter 7.2 cm long solid cylindrical core. The short axis of each loop was 1.9 cm with an overlap of 0.3 cm (Figure 1.a). Both a transceiver and an actively detuned receive-only versions of the ERC-2L were constructed following the same geometry. A commercial version with the same general geometry of the ERC-2L is available for 1.5 and 3 T (Sentinelle Endorectal Coils, Invivo, Gainesville, FL).
In addition to the ERC-2L design, a transceiver version of a two-channel microstrip-loop ERC (ERC-ML) was built. The ERC-ML had a 2.2 cm diameter 7 cm long cylindrical core. The ground plane of the microstrip element was placed on the center axis of the core and the loop element was centered around the top conductor of the microstrip element with a short-axis diameter of 1.4 cm (Figure 1.c). The ERCs were positioned inside a sterilizable housing when used in any imaging or heating studies (Figure 1.e).
A previously described single-channel receive-only balloon-type ERC (ERC-b) was used for comparison by replacing the electrical components of a commercially available 3 T coil (Medrad eCoil, Bayer Healthcare, Whippany, NJ) (23 ). The size of the ERC-b loop was 7 × 3.5 cm2.
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