Esomeprazole magnesium hydrate

Manufactured by Merck Group

Sourced in India, Spain

Esomeprazole magnesium hydrate is a chemical compound primarily used as a pharmaceutical ingredient. It is a proton pump inhibitor that works by reducing the production of gastric acid in the stomach.

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Esomeprazole

3 protocols using esomeprazole magnesium hydrate

Simultaneous Quantification of Esomeprazole, Rabeprazole, and Levosulpiride

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Reference standards of esomeprazole magnesium hydrate, rabeprazole sodium, levosulpiride and lansoprazole (internal standard, IS) were purchased from Sigma-Aldrich (Hyderabad, India). HPLC grade ammonium formate was procured from Thermo Fisher Scientific (Mumbai, India). HPLC grade methanol and acetonitrile were procured from J.T Baker (Phillipsburg, USA). Milli-Q water (18.2 mΩ and TOC≤50 ppb) generated using a Milli-Q purification system (Millipore, Bangalore, India) was used throughout the study. Methyl tert-butyl ether and ethyl acetate were purchased from Rankem (Hyderabad, India). Drug-free human plasma was procured from King George Hospital (Visakhapatnam, India).

Chunduri R.H, & Dannana G.S. (2016). Development and validation of a high throughput UPLC–MS/MS method for simultaneous quantification of esomeprazole, rabeprazole and levosulpiride in human plasma. Journal of Pharmaceutical Analysis, 6(3), 190-198.

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Cytotoxicity Evaluation of Pharmaceuticals

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Es omeprazole magnesium hydrate, omeprazole, N-acetylcysteine (NAC), thapsigargin (TG), RPMI-1640, MCDB-153 medium, and antibiotics were from Sigma-Aldrich (Madrid, Spain). Fetal bovine serum (FBS) and Hank's balanced salt solution (HBSS) were both from Life Technologies (Madrid, Spain). All compounds except pepstatin A, which was dissolved in 100% ethanol and NAC, which was dissolved in culture media, were dissolved in DMSO and made up with the media so that the final concentration of the vehicle was not >0.04% (v/v).

Chueca E., Apostolova N., Esplugues J.V., García-González M.A., Lanas Á, & Piazuelo E. (2016). Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma Cells. Frontiers in Pharmacology, 7, 452.

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Chiral LC-MS Analysis of Proton Pump Inhibitors

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Macrocyclic glycopeptides-type chiral columns with identical dimensions (100 × 4.6 mm, 5-μm particle size)ristocetin A-based Chirobiotic R, teicoplanin-based Chirobiotic T, teicoplanin aglycone-based Chirobiotic TAG, and vancomycin-based Chirobiotic V were purchased from Supelco/Astec, (Milwaukee, Wisconsin). Pantoprazole sodium hydrate (≥98%), esomeprazole magnesium hydrate (≥98%), and triethylamine (≥99%) were ordered from Sigma-Aldrich Hungary (Budapest). Gradient grade methanol (MeOH), acetonitrile (ACN), ethanol (EtOH), glacial acetic acid, ammonium acetate (≥98%), ammonium formate (≥99%), and formic acid (≥98%) were purchased from Merck (Darmstadt, Germany). Controloc 20-mg tablets were obtained from Central Pharmacy of Semmelweis University (Budapest, Hungary). Ultrapure, deionized water was prepared by a Milli-Q Direct 8 Millipore system (Milford, Massachusetts).

Papp L.A., Foroughbakhshfasaei M., Fiser B., Horváth P., Kiss E., Sekkoum K., Gyéresi Á., Hancu G., Noszál B., Szabó Z.I, & Tóth G. (2020). Reversed-phase HPLC enantioseparation of pantoprazole using a teicoplanin aglycone stationary phase-Determination of the enantiomer elution order using HPLC-CD analyses. Chirality, 32(2).

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