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Leksell gammaplan treatment planning system

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The Leksell GammaPlan Treatment Planning System is a software tool developed by Elekta for radiation treatment planning. It provides functionality for visualization, analysis, and optimization of radiation dose distribution for the Leksell Gamma Knife radiosurgery system.

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Lab products found in correlation

Perfexion unit, by Elekta (2 mentions) Leksell model c unit, by Elekta (2 mentions) Leksell gamma knife perfexion unit, by Elekta (2 mentions) Signa hd, by GE Healthcare (1 mentions) Leksell gamma knife, by Elekta (1 mentions)

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GammaPlan Treatment Planning System Leksell GammaPlan system Leksell GammaPlan GammaPlan® system GammaPlan

5 protocols using leksell gammaplan treatment planning system

1

Leksell Gamma Knife Radiosurgery

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All were treated with either the Leksell Model B, C, or Perfexion units (Elekta AB). Prior to radiosurgery, patients underwent a high-resolution MRI of the brain. Treatment planning was performed using the Leksell GammaPlan Treatment Planning System (Elekta AB). A median dose of 18 Gy (range 8-22 Gy) to the 50% isodose line was prescribed. Prescription dose was determined based on the guidelines previously published by Shaw et al.[4 (link)]
Black P.J., Page B.R., Lucas JT J.r., Hughes R.T., Laxton A.W., Tatter S.B., Munley M.T, & Chan M.D. (2015). Factors that determine local control with gamma knife radiosurgery: The role of primary histology. Journal of Radiosurgery and SBRT, 3(4), 281-286.
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2

Leksell Gamma Knife Radiosurgery

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Patients were treated with Leksell Model B, C, or Perfexion units (Elekta AB). Prior to radiosurgery, patients underwent a high-resolution MRI of the brain. Treatment planning was performed using the Leksell GammaPlan Treatment Planning System (Elekta AB). A median dose of 20 Gy prescribed to the 50% isodose line was prescribed. Prescription dose was determined based on the guidelines previously published by Shaw et al. [15 (link)].
Johnson A.G., Ruiz J., Hughes R., Page B.R., Isom S., Lucas J.T., McTyre E.R., Houseknecht K.W., Ayala-Peacock D.N., Bourland D.J., Hinson W.H., Laxton A.W., Tatter S.B., Debinski W., Watabe K, & Chan M.D. (2015). Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases. Oncotarget, 6(22), 18945-18955.
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3

Stereotactic Radiosurgery for Brain Metastases

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Patients were evaluated and consented by a radiation oncologist and neurosurgeon before GKRS. Patients were treated with a Leksell model C unit (Elekta, Norcross, GA) before May 2009 and with a Leksell GammaKnife Perfexion unit (Elekta) thereafter. Before undergoing radiosurgery, the patient underwent a 1.5T or 3T high-resolution contrast-enhanced stereotactic MRI and/or CT study of the brain. Treatment planning was performed using the Leksell GammaPlan treatment planning system (Elekta). Dose prescription was determined according to size and volume of the metastasis, and generally following the guidelines published by Shaw et al (12 (link)) for single-fraction radiosurgical treatment of previously irradiated primary brain tumors and brain metastases.
Lucas JT J.r., Colmer HG I.V., White L., Fitzgerald N., Isom S., Bourland J.D., Laxton A.W., Tatter S.B, & Chan M.D. (2015). Competing Risk Analysis of Neurologic versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage After Whole-Brain Radiation Therapy Failure: Who Actually Dies of Their Brain Metastases?. International journal of radiation oncology, biology, physics, 92(5), 1008-1015.
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4

Stereotactic Radiosurgery for Trigeminal Neuralgia

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All patients underwent SRS using a gamma knife (Leksell Gamma Knife, Elekta Instruments, Atlanta, Ga), model C. Under mild sedation and local anesthesia, the Leksell Model G stereotactic frame (Elekta Instruments) was applied. Stereotactic MRI was performed on each patient to identify the trigeminal nerve and its course from the pons, using contrast enhancement. A three-dimensional time-of-flight (3D-TOF) sequence was performed using a 1.5-Tesla MRI scanner (General Electric Signa HD). Fast imaging, employing steady-state acquisition sequence, provides images included in the MR protocol. A treatment plan was implemented using the Leksell Gamma Plan treatment planning system (Elekta AB).
Stereotactic coordinates were calculated for two isocenters; one 8-mm isocenter was placed on the Meckel’s Cavum and a 4 mm was placed at the adjacent fibers of the trigeminal nerve from the TG. The maximum dose was 86 Gy (43 Gy prescribed to the 50% isodose) [Figure 1].
Somaza S., Montilla E.M, & Mora M.C. (2019). Gamma knife radiosurgery on the trigeminal ganglion for idiopathic trigeminal neuralgia: Results and review of the literature. Surgical Neurology International, 10, 89.
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5

Stereotactic Radiosurgery for Brain Metastases

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Prior to treatment failure, all patients had been treated with Gamma Knife radiosurgery (Leksell Model C unit prior to May 2009, Leksell Gamma Knife Perfexion unit after May 2009; Elekta AB, Stockholm, Sweden). Prior to radiosurgery, patients underwent a high-resolution contrast-enhanced stereotactic MRI study of the brain. Treatment planning was performed using the Leksell GammaPlan Treatment Planning System (Elekta AB). Dose prescription was determined based on size and volume of each metastasis, generally following the guidelines published by Shaw et al. for single fraction radiosurgical treatment of brain metastases [8 (link)]. The median marginal dose of the previously treated lesion was 18 Gy (range 10– 24 Gy) and the median resected volume at the time of stereotactic radiosurgery failure was 4.9 cc (range 0.2–53 cc).
Mu F., Lucas JT J.r., Watts J.M., Johnson A.J., Bourland J.D., Laxton A.W., Chan M.D, & Tatter S.B. (2015). Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 22(3), 561-565.
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