Exemestane

Manufactured by Bio-Techne

Sourced in United Kingdom

Exemestane is an aromatase inhibitor, a type of laboratory equipment used in research applications. It functions by inhibiting the aromatase enzyme, which is responsible for the conversion of androgens to estrogens. Exemestane is commonly used in the study of hormonal regulation and related research areas.

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Lab products found in correlation

Letrozole, by Bio-Techne (1 mentions) Anastrozole, by Bio-Techne (1 mentions) Sulforaphane, by Merck Group (1 mentions) Ascorbate, by Merck Group (1 mentions) Collagenase dispase, by Merck Group (1 mentions) Letrozole, by Cayman Chemical (1 mentions) Osmium tetroxide, by Merck Group (1 mentions) Hematoxylin, by Merck Group (1 mentions) Forskolin, by Merck Group (1 mentions) Corn oil, by Merck Group (1 mentions) Fura 2 am, by Thermo Fisher Scientific (1 mentions) Dulbecco s modified eagle s medium dmem, by Thermo Fisher Scientific (1 mentions) Hanks balanced salt solution (hbss), by Thermo Fisher Scientific (1 mentions) Am 0902, by Bio-Techne (1 mentions) 4 oht, by Merck Group (1 mentions) L glutamine, by Thermo Fisher Scientific (1 mentions) Penicillin streptomycin, by Thermo Fisher Scientific (1 mentions) Fluo 4 am, by Thermo Fisher Scientific (1 mentions) Fetal bovine serum (fbs), by Merck Group (1 mentions) Protease inhibitor cocktail, by Merck Group (1 mentions)

3 protocols using exemestane

Activating murine PAR2 receptor

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Exemestane, letrozole and anastrozole were purchased from Tocris Bioscience (Bristol, UK). The activating peptide (PAR2-AP, SLIGRL-NH₂) and its reverse peptide (PAR2-RP, LRGILS-NH₂) of the murine PAR2 receptor were synthesized from G. Cirino (University of Naples, Naples, Italy) and dissolved in distilled water. If not otherwise indicated, all other reagents were from Sigma-Aldrich (Milan, Italy). HC-030031 was synthesized as previously described45 (link).

Fusi C., Materazzi S., Benemei S., Coppi E., Trevisan G., Marone I.M., Minocci D., De Logu F., Tuccinardi T., Di Tommaso M.R., Susini T., Moneti G., Pieraccini G., Geppetti P, & Nassini R. (2014). Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1. Nature Communications, 5, 5736.

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Compound Acquisition and Experimental Setup

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Compounds were obtained as follows: sulforaphane (Sigma-Aldrich), exemestane (Tocris), letrozole (Cayman), (+)-JQ-1 and (−)-JQ-1 (MedChemExpress), tamoxifen (Sigma-Aldrich), 4-OHT (Sigma-Aldrich), hematoxylin (Sigma-Aldrich), eosin Y (Sigma-Aldrich), osmium tetroxide (Sigma-Aldrich), Fluo-4 AM (Invitrogen), Fura-2 AM (Invitrogen), ascorbate (Sigma-Aldrich), AM-0902 (Tocris), olive oil (Sigma-Aldrich), corn oil (Sigma-Aldrich), Dulbecco’s modified Eagle’s medium (DMEM; Gibco), fetal bovine serum (Sigma-Aldrich), penicillin-streptomycin (Gibco), l-glutamine (Gibco), forskolin (Sigma-Aldrich), collagenase/dispase (Sigma-Aldrich), Hanks’ balanced salt solution (HBSS; Gibco), laminin (Roche), poly-d-lysine (Sigma-Aldrich), protease inhibitor cocktail (Sigma-Aldrich), and 10% normal goat serum (Thermo Fisher Scientific).

Vasavda C., Xu R., Liew J., Kothari R., Dhindsa R.S., Semenza E.R., Paul B.D., Green D.P., Sabbagh M.F., Shin J.Y., Yang W., Snowman A.M., Albacarys L.K., Moghekar A., Pardo-Villamizar C.A., Luciano M., Huang J., Bettegowda C., Kwatra S.G., Dong X., Lim M, & Snyder S.H. (2022). Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Science Advances, 8(31), eabo5633.

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Comprehensive Chemical Reagent Inventory

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Chemicals were purchased as follows: Sigma-Aldrich (St. Louis, MO): 17β-estradiol (E₂), cycloheximide (CHX, translation inhibitor), 4-hydroxytamoxifen (4-OHT), finasteride (5α-reductase inhibitor), miconazole (general P450 inhibitor), exemestane (aromatase inhibitor), STX64 (steroid sulfatase inhibitor), 5-fluorouracil (5-FU), doxorubicin (Dox), actinomycin D (ActD, a transcriptional inhibitor), and flutamide (a selective androgen receptor modulator (SARM)); Tocris (Ellisville, MO): Fulvestrant (ICI 182, 780), 2,3-bis(4-hydroxyphenyl)propionitrile (DPN), an ERβ-selective agonist; 4,4',4”-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT), an ERα-selective agonist; and 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol (PHTPP, an ERβ-selective inhibitor); Steraloids (Wilton, NH): dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), DHEA 3β-sulfate (DHEA-S), 5-androstene-3α,17α-diol (ADIOL), 5-androstene-3,17-dione (ADIONE), and 5α-androstane-3β,17β-diol (3β-Adiol). The SARM bicalutamide (Casodex) was generously provided by Astra Zeneca (Macclesfield, UK).

Teng Y., Litchfield L.M., Ivanova M.M., Prough R.A., Clark B.J, & Klinge C.M. (2014). Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor. Molecular and cellular endocrinology, 392(0), 23-36.

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