Differences in the mean for each lipid levels, pre- and postindex HCQ use, were evaluated using the student’s t-test.
To explore the effect of the variables, considering effect modifiers (age, sex, race, statin use, post CRP values >10 mg/L), a multivariable regression model was performed (analysis of variance/analysis of covariance) for the change in different lipid levels.
For sensitivity analysis, marginal means of change were calculated for each lipid level by race and by controlling other variables.
All analyses were performed using STATA 11 for Windows (StataCorp; College Station, TX, USA).