All data are expressed as X ± S. Allele frequencies and genotypes of the four tag‐SNP loci in the case group and the control group were statistically analysed for Hardy–Weinberg equilibrium, odds ratio (OR) value and 95% confidence interval (CI) using
SPSS 22.0 and
STATA MP13 software. A two‐tailed
P < 0.05 was considered statistically significant. In addition, Pearson's
χ2 and Fisher's exact tests were used to calculate the allele frequencies of cases and controls, and MAF in controls was defined as baseline. After adjusting for age, sex and smoking status, ORs and 95% CIs were calculated using unconditional logistic regression analysis. The relationship between the selected SNPs and the risk of COPD was calculated using genotypic model analysis (codominant, dominant, recessive, overdominant and log additive) by the website software programme SNPStats.
23 Student's
t test was used to compare the differences in quantitative data if the data followed a normal distribution; otherwise, the
χ2 test was used. Comparison of dual fluorescence reporter gene activity was tested by Student's t test.
Wang Y., Zhou Q., Chen L., Dong L., Xiong M., Xie X., Zhao L., Xu J., Zheng Z., Wang J, & Lu W. (2022). Identification of genetic variants of the IL‐22 gene in association with an altered risk of COPD susceptibility. The Clinical Respiratory Journal, 16(8), 537-545.