Genescreen

Manufactured by Sanofi

Sourced in United States

GeneScreen is a compact and versatile lab equipment designed for DNA and RNA analysis. It features a high-resolution optical system and advanced software for accurate gene detection and quantification. The core function of GeneScreen is to provide researchers with a reliable tool for genomic research and molecular diagnostics.

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Lab products found in correlation

Amplicor version 1, by Roche (1 mentions) Amplicor v 1, by Roche (1 mentions)

2 protocols using genescreen

HIV Exposure Testing Protocol

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Cell pellets and plasma from HIV-exposed children were prepared from whole blood and stored at −70 °C. The last available sample was tested for HIV by ELISA on plasma if aged at least 18 months (GeneScreen; Sanofi Diagnostics Pasteur, Johannesburg, South Africa) or DNA PCR on cell pellets if aged less than 18 months (Roche Amplicor version 1.5; Roche Diagnostic Systems, Alameda, California, USA). If the last sample was positive, earlier samples were tested to determine timing of infection [8 (link)].

Evans C., Chasekwa B., Ntozini R., Humphrey J.H, & Prendergast A.J. (2016). Head circumferences of children born to HIV-infected and HIV-uninfected mothers in Zimbabwe during the preantiretroviral therapy era. AIDS (London, England), 30(15), 2323-2328.

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Longitudinal HIV Exposure in Zimbabwe

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The ZVITAMBO trial was undertaken prior to maternal or infant ART availability (1997-2001).^{11 (link)} Briefly, 14, 110 mother-infant pairs were recruited at birth and followed for 1-2 years. Exclusion criteria included birthweight <1500g, plans to leave Harare, multiple pregnancy, and life-threatening medical conditions. Mothers underwent longitudinal HIV testing.^{11 (link)} Longitudinal blood samples from children were cryopreserved; the last available sample was HIV-tested by DNA PCR (Roche Amplicor,v1.5) or ELISA (GeneScreen;Sanofi Diagnostics Pasteur) depending on age. HEU infants in this study were defined as infants born to HIV-positive mothers who remained HIV-negative through 6-months of age.

Evans C., Chasekwa B., Rukobo S., Govha M., Mutasa K., Ntozini R., Humphrey J.H, & Prendergast A.J. (2020). Inflammation, cytomegalovirus and the growth hormone axis in HIV-exposed uninfected Zimbabwean infants. AIDS (London, England), 34(14), 2045-2050.

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