Nod sytwu

Manufactured by Jackson ImmunoResearch

Sourced in United States

The NOD/Sytwu is a laboratory equipment product offered by Jackson ImmunoResearch. It is designed to perform specific functions, but a detailed and unbiased description cannot be provided while maintaining conciseness without extrapolation or interpretation.

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Lab products found in correlation

Nod scid, by Jackson ImmunoResearch (1 mentions) Nod bdc2.5 tcr, by Jackson ImmunoResearch (1 mentions) Nod rag1, by Jackson ImmunoResearch (1 mentions) Nod rag 1 mice, by Jackson ImmunoResearch (1 mentions)

3 protocols using nod sytwu

NOD Mouse Strain Generation

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NOD/Sytwu (K^d, D^b, I-A^g7, I-E^null), B6.129/Il21r^–/–, and NOD/SCID mice were initially purchased from the Jackson Laboratory. B6.129/Il21r^–/– mice were backcrossed to the NOD strain for at least 10 generations. Blimp-1 CKO, BTg, and KRcTg NOD mice were established as described previously (4 (link), 6 (link), 32 (link)). NOD/Il21r^–/– and Blimp-1 CKO were crossed to obtain the DKO mice. The double-transgenic mice (BKTg) were generated by crossing BTg and KRcTg mice.

Liu Y.W., Fu S.H., Chien M.W., Hsu C.Y., Lin M.H., Dong J.L., Lu R.J., Lee Y.J., Chen P.Y., Wang C.H, & Sytwu H.K. (2022). Blimp-1 molds the epigenetic architecture of IL-21–mediated autoimmune diseases through an autoregulatory circuit. JCI Insight, 7(11), e151614.

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Murine Models for Type 1 Diabetes

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NOD/Sytwu (K^d, D^b, I-A^g7, I-E^null), NOD-Rag1^−/−, and NOD-BDC2.5 TCR transgenic mice were procured from The Jackson Laboratory (Bar Harbor, ME, USA). NOD-SCID mice were purchased from National Laboratory Animal Center (Taipei, Taiwan). All the mice were subsequently housed in specific pathogen-free facility provided by the animal center of National Defense Medical Center (Taipei, Taiwan). Experimental protocols requiring the use of mice were approved by the Institutional Animal Care and Use Committee of National Defense Medical Center.

Kulshrestha D., Yeh L.T., Chien M.W., Chou F.C, & Sytwu H.K. (2017). Peripheral Autoimmune Regulator Induces Exhaustion of CD4+ and CD8+ Effector T Cells to Attenuate Autoimmune Diabetes in Non-Obese Diabetic Mice. Frontiers in Immunology, 8, 1128.

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Generation of SPAK T-Cell Knockout Mice

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NOD/Sytwu (K^d, D^b, I-A^g7, I-E^null) and NOD.Rag1^−/− mice were purchased from The Jackson Laboratory. Stk39^−/− (SPAK KO) and Stk39^F/F mice with a C57BL/6 genetic background (36 (link)) were backcrossed to the NOD strain for at least 10 generations. NOD/Stk39^F/F mice were bred with the Lck^Cre mice to generate T-cell–specific SPAK knockout (SPAK CKO) mice.

Ciou J.J., Chien M.W., Hsu C.Y., Liu Y.W., Dong J.L., Tsai S.Y., Yang S.S., Lin S.H., Yen B.L., Fu S.H, & Sytwu H.K. (2024). Excess Salt Intake Activates IL-21–Dominant Autoimmune Diabetogenesis via a Salt-Regulated Ste20-Related Proline/Alanine-Rich Kinase in CD4 T Cells. Diabetes, 73(4), 592-603.

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