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G2019s lrrk2 tg fvb mice

Manufactured by Jackson ImmunoResearch
Sourced in United States

G2019S-LRRK2-Tg FVB mice are a transgenic mouse model that expresses the G2019S mutation in the LRRK2 gene. The G2019S mutation is associated with Parkinson's disease. These mice are a tool for studying the effects of this genetic mutation and its potential role in the development of Parkinson's disease.

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2 protocols using g2019s lrrk2 tg fvb mice

1

Genetically Modified LRRK2 Mice

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G2019S-LRRK2-Tg FVB mice were purchased from Jackson Laboratory (stock #009609, Bar Harbor, ME, USA). Non-Tg and G2019S-LRRK2-Tg heterozygous mice were prepared by crossing G2019S-LRRK2 heterozygous mice with wild-type mice. Genotyping was carried according to the vendor’s instructions. All animal procedures were approved by the Ajou University Institutional Animal Experimentation Committee (AMC-119).
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2

Generation and Characterization of LRRK2 Transgenic Mice

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G2019S-LRRK2-Tg FVB mice69 (link) were purchased from Jackson Laboratory (stock #009609, Bar Harbor, ME, USA). Cx3cr1–GFP (GFP/GFP) mice were kindly gifted from Dr Seog Bae Oh (Seoul National University School of Dentistry, Seoul, Korea). Non-Tg and G2019S-LRRK2-Tg heterozygote mice were prepared by crossing G2019S-LRRK2 heterozygote mice with wild-type FVB mice or Cx3cr1–GFP (GFP/GFP) mice19 (link). Genotyping was carried out as described in manufacturer's instruction (Jackson Laboratory). All animal procedures were approved by the Ajou University Institutional Animal Experimentation Committee (AMC-119).
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