The target ulcer is debrided in the operating room using a scalpel, scissors, and a curette under appropriate anesthesia. After hemostat and irrigation, the study device is applied to the surface of the wound and covered with a wound dressing, which the investigator/sub-investigator chooses from the following: polyurethane film dressing (3M Tegaderm Transparent Film Dressing; 3M, Maplewood, Minnesota, USA), silicone-faced wound dressing (SI-Aid; ALCARE, Tokyo, Japan), low-adherent absorbent dressing (Melolin; Smith & Nephew, Hull, UK), and polyurethane form dressing (Hydrosite thin type; Smith & Nephew). If the investigator/sub-investigator is afraid of overproducing wound exudate that causes poor hydrogel formation of silk-elastin, the investigator/sub-investigator applies not the study device but a wound dressing or an ointment. In this case, the investigator/sub-investigator applies the study device on the day after the surgery. Antibiotics are administered intravenously before and after the surgery.
Melolin
Manufactured by Smith & Nephew
Sourced in United Kingdom, Australia
Melolin is a sterile, non-woven wound dressing designed for the management of various types of wounds. It is made of a highly absorbent material that helps to maintain a moist wound environment, which can promote healing. Melolin is suitable for use on a variety of wounds, including minor cuts, abrasions, and surgical sites.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using melolin
1
Silk-Elastin Wound Dressing Application
2
Porcine Burn Injury Model Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
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Preparation of the burn sites included clipping the hair on the back and flanks and marking the sites for burning using the device as a template. Protective clear plastic sheets were taped in place (Fig 2A1 ) to cover the immediate surrounding area and reduce the risk of an unintentional burn. Immediately prior to scalding, the device and tubing was pre-warmed for at least 1 min by running the system external to the pig. After pre-warming, the device was placed perpendicular to the skin surface and weighted rings were placed on top to provide uniform downward pressure for a leak proof seal. The same operator supported the device with one hand and controlled the hot water inflow tube with their other hand (Fig 2C ). At the end of the exposure the inflow of hot water was halted by pinching the tube, the whole scald device was lifted off the animal and any excess water was quickly mopped up with a towel. A range of burn conditions were tested; 50°C for 1, 2, 5 and 10 min; and 60, 70, 80 and 90°C for 5 sec.
After wound assessments (detailed below), all burns were dressed with Melolin™ and Fixomull® (Smith & Nephew, Australia) which was changed at each time point. To further protect the burn area, custom made garments [15 (link)] were fitted.
After wound assessments (detailed below), all burns were dressed with Melolin™ and Fixomull® (Smith & Nephew, Australia) which was changed at each time point. To further protect the burn area, custom made garments [15 (link)] were fitted.
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