Liver stiffness measurement (LSM) was performed with an Aixplorer ultrasound system (SuperSonic Imagine SA, Aix-en-Provence, France) and a SuperLinear SL15-4 probe. LSM was targeted at liver parenchyma free of large vessels, with the upper edge 0.5 to 1 cm away from the liver capsule. The region of interest for LSM was 1.0 cm diameter. LSM detection and analysis were performed by 2 sonographers.
Aixplorer ultrasound system
Manufactured by SuperSonic Imagine
Sourced in France
The Aixplorer ultrasound system is a diagnostic imaging device developed by SuperSonic Imagine. The system uses advanced ultrasound technology to generate high-quality images of internal body structures. It is designed to assist medical professionals in the evaluation and diagnosis of various medical conditions.
Automatically generated - may contain errors
Lab products found in correlation
Sc6 1, by SuperSonic Imagine (3 mentions)
Shearwave elastography, by SuperSonic Imagine (2 mentions)
Vega3, by TESCAN (1 mentions)
K350 sputter coater, by Quorum Technologies (1 mentions)
Infinite m nano plate reader, by Tecan (1 mentions)
Sl10 2, by SuperSonic Imagine (1 mentions)
Osirix workstation, by Pixmeo (1 mentions)
Fibroscan 502, by Echosens (1 mentions)
Mylab twice ultrasound system, by Esaote (1 mentions)
Iu22 scanner, by Philips (1 mentions)
Sonovue, by Bracco (1 mentions)
Aplio 500, by Toshiba (1 mentions)
Resona 7, by Mindray (1 mentions)
24 protocols using aixplorer ultrasound system
1
Liver Stiffness Measurement Ultrasound Protocol
2
Liver Fibrosis Staging by 2D-SWE
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
2D-SWE was performed using the Aixplorer ultrasound system (Supersonic Imagine, France). Liver stiffness was measured in kilopascals (kPa) and expressed in a 0-4 scoring system, corresponding to the manufacturer-recommended histologic METAVIR scale related to the stage of liver fibrosis, with appropriate ranges separately proposed for HBV, HCV infections and non-alcoholic steatohepatitis (NASH). It is worth noting that the proposed cut-offs have been changing as the results of larger studies providing new data became available. Currently (since 2015), manufacturer-recommended cut-offs for HCV infection and NASH indicate F0-1 for < 7.1 kPa, F2 for 7.1-9.2 kPa, F3 for 9.2-13.5 kPa, and F4 for liver stiffness of > 13.5 kPa. In HBV infection the proposed cut-offs are: < 7.1 kPa for F0-1, 7.1-8.1 kPa for F2, 8.1-11.5 kPa for F3 and > 11.5 kPa for F4 [9 (link)].
3
Liver Stiffness Measurement by 2D-SWE
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All patients underwent LSM examination immediately prior to RFA treatment. Aixplorer ultrasound system (Supersonic Imagine, France) with a convex broadband probe (SC6-1, 1–6 MHz) was used to perform LSM measurement by 2D-SWE technology in accordance with the manufacturer’s instructions. All LSM measurements were conducted by one experienced sonographer blind to the patients’ information. Patients were placed in a supine position with the right arm in maximum abduction, and expose right intercostal space for scanning right liver lobe. Valid LSM was defined as 10 effective measurements for each patient. The result of LSM was expressed as the mean (M) of effective measurements in kilopascals (kPa). The Sonographer were blinded to all data of patient.
4
Non-Invasive Liver Stiffness Measurement
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Liver stiffness was measured using 2D-SWE two weeks before liver histology. As instructed by the manufacturer, the procedure was performed by Aixplorer ultrasound system (Supersonic Imagine, France) using a curved broadband probe (SC6-1, 1-6 MHz). For more relevant results, patients were asked to fast six hours before the procedure. They were positioned in right lateral decubitus with a complete abducted right arm to get access liver from intercostal spaces. Ten image acquisitions of each patient were considered as a favourable liver stiffness measurement (LSM). A single operator blinded to the patients' data reported LSM (liver stiffness measurement) as the mean (M) of valid measurements in kilopascals (kPa).
5
Multitechnique Cargo Delivery Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The Cobolt Tor XS (532 nm, 50 µJ, 1.9 ns) was used as a light source combined with a focusing lens (Olympus 4×/0.1 n.a.).
An Aixplorer ultrasound system (SuperSonic Imagine, Aix-en-Provence, France) with a convex probe XC6-1 and an SE12-3 MHz transrectal probe and an Epiq 5 (Philips Medical Systems B.V., Best, The Netherlands) C10-4ec MHz transrectal probe were used for triggered cargo release.
Scanning electron microscopy (SEM) measurements were performed with a VEGAIII (TESCAN, Brno, Czech Republic) microscope. The operating voltage was 5 kV. The gold was deposited onto the sample surface (~5 nm gold layer) using an Emitech K350 sputter-coater (Quorum Technologies Ltd., Ashford, UK).
The absorption spectra of Prednol-L were recorded using a TECAN Infinite M Nano + plate reader (TECAN, Männedorf, Switzerland) in standard 96-hole UV-transparent plates (Corning, NY, USA).
An Aixplorer ultrasound system (SuperSonic Imagine, Aix-en-Provence, France) with a convex probe XC6-1 and an SE12-3 MHz transrectal probe and an Epiq 5 (Philips Medical Systems B.V., Best, The Netherlands) C10-4ec MHz transrectal probe were used for triggered cargo release.
Scanning electron microscopy (SEM) measurements were performed with a VEGAIII (TESCAN, Brno, Czech Republic) microscope. The operating voltage was 5 kV. The gold was deposited onto the sample surface (~5 nm gold layer) using an Emitech K350 sputter-coater (Quorum Technologies Ltd., Ashford, UK).
The absorption spectra of Prednol-L were recorded using a TECAN Infinite M Nano + plate reader (TECAN, Männedorf, Switzerland) in standard 96-hole UV-transparent plates (Corning, NY, USA).
6
Liver Stiffness Measurement by 2D-SWE
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
LSM by 2D‐SWE was performed using the Aixplorer ultrasound system (SuperSonic Imagine SA, Aix‐en‐Provence, France). Patients were placed in a supine position, with the right arm in extension. The operator selected a region of the right lobe of the liver with good spatial resolution for B‐mode ultrasound imaging, free of large vascular structures and at least 15 mm below the capsule through a right intercostal space, and during breath hold activated 2D‐SWE. Once a colour map with complete and homogeneous filling was obtained in the assessment area, a region of interest 15 mm in diameter was positioned in the centre of the colour map to measure stiffness using the Q box tool. We obtained three successful and valid measurements for each patient and used the mean value and the standard deviation of these measurements as liver stiffness measure.16 Variability (SD) over 30% of the average liver stiffness value was considered as unreliable measurement.17 When the operator obtained little or no signal in the region of interest for all acquisitions, the measurements were defined as failures.
7
Liver and Spleen Stiffness Measurement by 2D-SWE
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All patients underwent LSM and SSM by two-dimensional (2D)-SWE performed by a single experienced operator (> 500-exam experience) in fasting patients. The Aixplorer® ultrasound system (Supersonic Imagine S.A., Aix-en-Provence, France) with an abdominal 3.5 MHz curved array probe was used, as recommended. 2D-SWE measurements were performed at each patient’s initial assessment. Ten reliable LSM and ten reliable SSM values were obtained from each patient and the mean values were then calculatedrespectively. The SD was < 20% of the mean values of LSM and SSM, respectively.
8
Liver Stiffness Measurement by 2D-SWE
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Liver stiffness measurement was done in left lateral decubitus, while the right arm was abducted maximally in 6 h fasted patients by 2D-SWE. The measurement was carried out by a curved broadband probe (SC6-1, 1–6 MHz) using the Aixplorer ultrasound system (Supersonic Imagine, France). Ideal liver stiffness result (LSM) was according to the mean image acquisitions of everyone. A blinded operator reported the mean (M) of ten valid LSM (liver stiffness measurement) in kilopascals (kPa).
9
Ultrasound Exposure Effects on Neonatal Mice
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
We set the experimental model with reference to research by Li et al. [5 (link)]. An Aixplorer ultrasound system (SuperSonic Imagine, Aix-en-Provence, France) equipped with a 4–15 MHz linear-array transducer was used in this study to generate 2D-SWE. Three neonatal mice born within 48 hours of the start of the experiment were fixed to a homemade board (Figure 1A ), with a 3 cm water bag placed between the probe and the neonatal mice to improve the focus of the ultrasound on the mice. A standard image shows the mouse head, color-coded by 2D-SWE (Figure 1B ). Neonatal mice were divided into a control group or into groups exposed to 2D-SWE for 10 minutes (group S1), 20 minutes (group S2), or 30 minutes (group S3). The control group was sham-irradiated for 30 minutes; that is, the fixed placement method and ultrasound probe placement were the same as the 2D-SWE irradiation group, but the ultrasound instrument was turned off. Some of the mice in each group were sacrificed immediately after irradiation. Brains were collected and then analyzed by western blot, PCR, and TUNEL tests. The remaining members of the groups were sacrificed 24 hours after the end of irradiation. Western blot and PCR experiments were performed to study the duration of the effect on BDNF.
10
Transfontanellar Ultrasound Evaluation of Preterm Neonates
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All cUS were performed using the CE-marked Aixplorer ultrasound system (Supersonic Imagine, Aix-en-Provence, France) with a 6 MHz central frequency linear probe (SL10-2 Supersonic Imagine, 192 elements, pitch 0.2 mm). Both conventional B-mode cUS and SWE imaging sequences complies with international standard in terms of power and acoustic emission for pediatric transfontanellar ultrasound system applications (Food and Drug Administration (FDA) Track 3: (MI < 1.9, ISPTA < 720 mW/cm2 and ISPPA < 190 W/cm2). B-mode acquisitions were performed using sagittal and coronal planes, and Shear Wave Elastrography (SWE) mode were acquired using sagittal planes. The same three operators performed the examinations. The operators were radiology technologist specialized in paediatric ultrasound acquisition for more than 7 years. For preterm neonates, examinations were performed at day of life 3 (DOL 3), 8 (DOL 8), 21 (DOL 21) and at term equivalent age (TEA, 40 ± 1 weeks of postmenstrual age) in accordance with our standardized practice. For term neonates, there was only one acquisition at DOL 3.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!