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Sigmaplot 8

Manufactured by IBM
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Sourced in United States

SigmaPlot 8.0 is a data analysis and graphing software developed by Systat Software Inc. It is designed to provide users with tools for visualizing, analyzing, and presenting data. The software offers a range of features for creating high-quality graphs and charts, as well as performing advanced statistical analysis.

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Lab products found in correlation

Sigmastat 3, by IBM (3 mentions) Versamax, by Molecular Devices (2 mentions) Statistica 12, by StatSoft (1 mentions) Axopatch 200b amplifier, by Molecular Devices (1 mentions) Clampfit 8, by Molecular Devices (1 mentions) Pclamp software, by Molecular Devices (1 mentions) Imagequant 5, by Cytiva (1 mentions) Spectramax i3x, by Molecular Devices (1 mentions) Spss computer software, by IBM (1 mentions) Spss 15.0 version, by IBM (1 mentions) Sas software, by SAS Institute (1 mentions) Sas 9, by SAS Institute (1 mentions) Npar1way, by SAS Institute (1 mentions) Statistica version 7, by StatSoft (1 mentions)

Spelling variants of this product

SigmaPlot (153 citations) SigmaPlot V.8.0 (2 citations) SigmaPlot 2002 for Windows Version 8.02 (2 citations)

28 protocols using sigmaplot 8

1

Statistical Analysis of Research Data

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For statistical evaluation of results and significance testing of group differences, a Mann–Whitney test was performed using GraphPad Prism software (Version 5.0, GraphPad Software Inc., San Diego, CA, USA) and graphs were generated using Sigma Plot 8.0 software (SPSS Inc., Chicago, IL, USA) and GraphPad Prism software. Data were presented as means (and ±S.E.M.). Groups were considered to be significantly different at p < 0.05 for a parameter.
Bazwinsky-Wutschke I., Zipprich A, & Dehghani F. (2017). Daytime-Dependent Changes of Cannabinoid Receptor Type 1 and Type 2 Expression in Rat Liver. International Journal of Molecular Sciences, 18(9), 1844.
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2

Comparison of Statistical Methods

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Data were expressed as mean ± standard deviation (SD). Statistical analysis was performed using SigmaPlot 8.0 statistical software (SPSS Inc., Chicago, IL, USA), and a Student t-test was set to p < 0.05 and p < 0.005.
Lee S., Jeong S., Lee C., Oh J, & Kim S.C. (2016). Mesenchymal Stem Cells Derived from Human Exocrine Pancreas Spontaneously Express Pancreas Progenitor-Cell Markers in a Cell-Passage-Dependent Manner. Stem Cells International, 2016, 2142646.
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3

Pharmacokinetics and Xenograft Efficacy

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Unless otherwise indicated, all experiments have been performed independently at least three times. Half-maximal inhibitory concentration (IC50) values were calculated using Sigmaplot 8.0 (SPSS Inc., Chicago, IL, USA), computing a four-parameter logistic equation from inhibition curves. Total drug exposure in mice and Cmax in rats was compared using an unpaired t-test. Inhibitor efficacy in the myeloma xenograft model was compared using a two-way ANOVA with Bonferroni posttests comparing all treatment conditions.
Wang Z., Dove P., Wang X., Shamas-Din A., Li Z., Nachman A., Oh Y.J., Hurren R., Ruschak A., Climie S., Press B., Griffin C., Undzys E., Aman A., Al-awar R., Kay L.E., O'Neill D., Trudel S., Slassi M, & Schimmer A.D. (2015). FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing. Cell Death & Disease, 6(7), e1815-.
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4

Concentration-response Characterization of Compounds

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The test substances were applied in an alternating manner with 5-HT. Therefore, the currents of the test substances or the modulated currents were normalized to the mean of the 5-HT-induced currents before and after the test substance was applied. The concentration-response data were fitted with the Hill equation with variable slope using SigmaPlot 8.0 (SPSS). Thereby, the calculation of the EC50 and IC50-values was done. The deviations are represented by the standard error of the mean (SEM). The datasets were tested for statistically significant differences through Student's t-test using Excel 2010 (Microsoft) (*p < 0.05; **p < 0.005; ***p < 0.0005). For multiple comparisons, the significance levels were corrected via Bonferroni-correction.
Herbrechter R., Ziemba P.M., Hoffmann K.M., Hatt H., Werner M, & Gisselmann G. (2015). Identification of Glycyrrhiza as the rikkunshito constituent with the highest antagonistic potential on heterologously expressed 5-HT3A receptors due to the action of flavonoids. Frontiers in Pharmacology, 6, 130.
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5

Statistical Analysis of Experimental Data

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Experimental results were expressed as mean ± standard deviation (SD) of three parallel measurements (SigmaPlot 8.0; SPSS Inc. Chicago, IL, USA).
Huang S.C., Wang P.W., Kuo P.C., Hung H.Y, & Pan T.L. (2018). Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus. Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 23(7), 1705.
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6

Paclitaxel Median Inhibitory Concentrations

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The median inhibitory concentrations (IC50) of paclitaxel were calculated using Sigma Plot 8.0 software (SPSS, Inc., Chicago, IL). All numerical data were expressed as the mean ± SD. Significance of the difference between two groups was determined with the Mann–Whitney U test. A p value less than 0.05 was considered to be statistically significant.
Ho C.M., Huang C.J., Huang S.H., Chang S.F, & Cheng W.F. (2015). Demethylation of HIN-1 reverses paclitaxel-resistance of ovarian clear cell carcinoma through the AKT-mTOR signaling pathway. BMC Cancer, 15, 789.
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7

Statistical Analysis of Two-Way Interactions

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Sources of significant two-way interactions were examined by main effect analysis. F-values are only reported for significant interactions and main effects, unless non-significant main effects or interactions are necessary to illustrate a relevant lack of significance. Effect sizes of significant ANOVAs are reported as partial eta squared (η2p). The Neuman-Keuls test was used for post-hoc comparison of means where appropriate. The alpha level was set at 0.05. All statistical analyses were conducted using the Statistica 12 software package (StatSoft, Inc., Tulsa, OK, USA). Figures were made using the SigmaPlot 8.0 software package (SPSS, Chicago, Il, USA).
Harkness J.H., Wells J., Webb S, & Grimm J.W. (2016). Extended Exposure to Environmental Cues, but not to Sucrose, Reduces Sucrose Cue-reactivity in Rats. Learning & behavior, 44(1), 59-66.
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8

Statistical Analysis of Experimental Data

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Data were treated with ANOVA and a post hoc test using SigmaPlot 8.0 and Systat 10.0 (SPSS Inc., Chigago, III). Comparison of 2 means was performed using paired or unpaired Student's t test, as appropriate. All p values were two-tailed, and p<0.05 was required to reject the null hypothesis. Results were expressed as mean±SEM of triplet experiments.
Chen Y., Lin P.X., Hsieh C.L., Peng C.C, & Peng R.Y. (2014). The Proteomic and Genomic Teratogenicity Elicited by Valproic Acid Is Preventable with Resveratrol and α-Tocopherol. PLoS ONE, 9(12), e116534.
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9

qPCR Data Analysis Protocol

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Continuous normally distributed variables are summarized and presented as the mean ± standard deviation (SD). qPCR data were presented as the mean value, determined using duplicates. To calculate the relative expression, the expression of the control was fixed at 1. Statistical analysis was performed using SigmaPlot 8.0 statistical software (SPSS Inc., Chicago, IL, USA), and two-sided Student’s t tests were used. Differences with p < 0.05 were considered significant.
Lee S., Lee C.M, & Kim S.C. (2016). Adult human pancreas-derived cells expressing stage-specific embryonic antigen 4 differentiate into Sox9-expressing and Ngn3-expressing pancreatic ducts in vivo. Stem Cell Research & Therapy, 7, 162.
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10

ICD-10 Diagnosis and Statistical Analysis

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Data processing was based on the documented diagnosis key (according to ICD-10 coding) in the MCS ISYNET (version 6.56.1404 NFAArzt) for outpatients, or on the ICPM search list with the ORBIS Software (QRP version 1.01.02.002) and the digital patient file Pegasos for inpatients.
Statistical analysis was performed with SigmaPlot 8.0 and SigmaStat 3.0 (SPSS Inc, Chicago, USA). Firstly, a test for normal distribution was performed for each record. Depending on whether it was a normally distributed or not normally distributed sample, the specific test was performed, including analysis of variance (ANOVA). The significance level was set at P≤0.05.
Aurich M., Hofmann G.O., Rolauffs B, & Gras F. (2014). Differences in Injury Pattern and Prevalence of Cartilage Lesions in Knee and Ankle Joints: A Retrospective Cohort Study. Orthopedic Reviews, 6(4), 5611.
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