PET imaging was performed using an Eminence STARGATE scanner (Shimadzu, Kyoto, Japan). After injecting 185 MBq of [18F]THK-5117 or 296 MBq of [11C]PiB, dynamic PET images were obtained for 90 min or 70 min, respectively. MR scans were performed in all subjects. T1-weighted and T2-weighted MR images were obtained using a SIGNA 1.5-Tesla machine (General Electric, Milwaukee, WI). [18F]THK-5117 PET images from 60 to 80 min post-injection were used for the following analysis.
Signa 1.5 tesla machine
Manufactured by GE Healthcare
Sourced in United States
The SIGNA 1.5-Tesla machine is a magnetic resonance imaging (MRI) system developed by GE Healthcare. It is designed to produce high-quality diagnostic images of the human body. The SIGNA 1.5-Tesla machine utilizes a 1.5-Tesla superconducting magnet to generate a strong magnetic field, which, in combination with radio frequency (RF) pulses and gradient coils, allows for the acquisition of detailed anatomical and functional information.
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Lab products found in correlation
4 protocols using signa 1.5 tesla machine
1
PET Imaging of Tau and Amyloid
2
Healthy Male Subjects PET Brain Scan
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All studies were performed under a protocol approved by the Ethics Committee of the Tokyo Metropolitan Institute of Gerontology. Five healthy, male subjects participated in this study (mean age ± SD, 22.4 ± 2.6 years old, range: 21 to 27 years old). Subjects were all right-handed and screened for history of neurological, psychiatric, and physical diseases. All subjects did not have a history of alcoholism and not on any medications to affect brain function. Caffeine intake was not allowed for at least 12 h prior to PET scanning. Written informed consent was obtained from all subjects after receiving an explanation of the study. Magnetic resonance (MR) images were acquired on all subjects to eliminate those with any brain abnormalities and to place regions of interest (ROIs) on PET images. The MR imaging was conducted with three-dimensional spoiled gradient-recalled echo (SPGR) imaging on a SIGNA 1.5 Tesla machine (General Electric, Waukesha, WI, USA) [6 (link)].
3
MRI Validation of Participant Neurological Health
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MRI was performed in the Tokyo Metropolitan Geriatric Hospital with three-dimensional spoiled gradient-recalled echo (SPGR) imaging and a SIGNA 1.5 Tesla machine (General Electric, Waukesha, WI, United States). The MRI images validated that the participants had no neurological diseases, such as stroke or brain tumors, and were used as a reference for placing the regions of interest (ROIs) on the PET images.
4
PET Imaging of Tau and Amyloid Deposition
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PET images were acquired using an Eminence STARGATE PET scanner (Shimadzu, Kyoto, Japan). After intravenous injection of [18F]THK5351 (185 MBq) or [11C]PiB (296 MBq), dynamic PET images were obtained for 60 ([18F]THK5351) or 70 ([11C]PiB) minutes. T1-weighted magnetic resonance images (MRI) were obtained using a SIGNA 1.5-Tesla machine (General Electric, Milwaukee, WI, USA) according to a previously described method [14 (link)]. Standardized uptake value (SUV) images of [18F]THK5351 (40–60 min after injection) and [11C]PiB (50–70 min after injection) were obtained by normalizing tissue radioactivity concentration by injected dose and body weight. The regional SUV-to-cerebellar cortex SUV ratio (SUVR) was used as an index of tracer retention. SPM12 software (SPM12; Wellcome Department of Imaging Neuroscience, UCL, London, UK) was used to coregister the PET images on the MRI image. PMOD Ver. 3.7 software (PMOD Technologies GmbH, Zurich, Switzerland) was used to draw regions of interest (ROIs) on the coregistered MRI image.
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